globin.bx.psu.edu

Globin Gene Server home page

Welcome to the Globin Gene Server. This site provides data and tools for studying the function of DNA sequences, with an emphasis on those involved in the production of hemoglobin. It includes information about naturally-occurring human hemoglobin mutations and their effects, experimental data related to the regulation of the beta-like globin gene cluster, and software tools for comparing sequences with one another to discover regions that are likely to play significant roles. Images of models and results.

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Globin Gene Server home page | globin.bx.psu.edu Reviews

<META> DESCRIPTION

Welcome to the Globin Gene Server. This site provides data and tools for studying the function of DNA sequences, with an emphasis on those involved in the production of hemoglobin. It includes information about naturally-occurring human hemoglobin mutations and their effects, experimental data related to the regulation of the beta-like globin gene cluster, and software tools for comparing sequences with one another to discover regions that are likely to play significant roles. Images of models and results.

<META> KEYWORDS

1 general

2 introduction

3 log of updates

4 human hemoglobin mutations

5 hbvar database

6 dberge ii

7 genome annotation

8 pairwise alignments

9 laj alignment viewer

10 multiple alignments

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general,introduction,log of updates,human hemoglobin mutations,hbvar database,dberge ii,genome annotation,pairwise alignments,laj alignment viewer,multiple alignments,multipipmaker,miscellaneous,restriction site utilities,publications and software

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Globin Gene Server home page | globin.bx.psu.edu Reviews

https://globin.bx.psu.edu

Welcome to the Globin Gene Server. This site provides data and tools for studying the function of DNA sequences, with an emphasis on those involved in the production of hemoglobin. It includes information about naturally-occurring human hemoglobin mutations and their effects, experimental data related to the regulation of the beta-like globin gene cluster, and software tools for comparing sequences with one another to discover regions that are likely to play significant roles. Images of models and results.

INTERNAL PAGES

globin.bx.psu.edu

1

dbERGEII introduction

http://globin.bx.psu.edu/dberge/menu.html

DbERGE II: Database of Experimental Results on Gene Expression. Introduction to dbERGE II. DbERGE II stores experiment and result details for various types of experiments. The current types of experiments available are:. DNA transfer experiments (Transfections and Transgenic mice). Binding assays (Gel shift, In-vivo footprint, In-vitro footprint and Methylation interference). ChIP - on - chip experiments. Explanation of each experiment type is given here. Choose dbERGE II version to query from:.

2

Pairwise Alignment Examples

http://globin.bx.psu.edu/html/pip/examples.html

The alpha-globin genes, or HBA. The beta-like globin gene cluster. Bruton's tyrosine kinase, or BTK. The cardiac myosin heavy chain genes. The T-cell receptor alpha/delta constant region. This page illustrates the utility of our pairwise alignment tools by presenting several examples, most of which compare some region of the human genome with the syntenic region from a rodent genome. In each case, the two DNA sequences were aligned using a new variant of our sim. That is, the sim. Comparison of the human.

3

Course Materials for BIO/CSE/STAT 597/8F, Spring 2002

http://globin.bx.psu.edu/courses/spring2002

Course Materials for BIO/CSE/STAT 597/8F. End-of-the-school-year party: Tue. April 30, Rm. 327 Thomas, 2:30-3:45. What is BIO/CSE 597F? Nucleic Acids Research 2002 Database Issue. Study guide for exam. Schedule for class presentations. The Aladdin web page has instructions for attaching it to Netscape or MS Internet-Explorer. Another popular program for reading PDF files is Adobe Acrobat Reader. Lecture 3 (without preliminary data). Supplementary material on SAGE (from NCBI). Paper on SAGE data errors.

4

Annotated images of multiple alignments: HSs in the beta-LCR

http://globin.bx.psu.edu/html/sample-align.html

Annotated images of multiple alignments: HSs in the beta-LCR. The following images show the alignment of mammalian beta-globin gene cluster sequences around hypersensitive sites (HSs) 1, 2, 3, 3.5, and 4 in the locus control region (LCR). PostScript and ASCII versions of a similar alignment are available through our multiple alignment server. PostScript files can be displayed with Aladdin's Ghostscript. Viewer, while the PDF versions below can be viewed with Adobe's Acrobat Reader. Selected restriction e...

5

Course Materials for BIO/CSE 597F, Fall 2001

http://globin.bx.psu.edu/courses/fall2001

Course Materials for BIO/CSE 597F. What is BIO/CSE 597F? Some of the materials will be presented as PostScript and PDF documents, so you will need to handle at least one of these formats. If your system doesn't already have one, you may want to fetch and install a free PostScript/PDF viewer manufactured by Aladdin Inc, called Ghostscript. The Aladdin web page has instructions for attaching it to Netscape or MS Internet-Explorer. Another popular program for reading PDF files is Adobe Acrobat Reader.

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Globin Gene Server home page

Welcome to the Globin Gene Server. This site provides data and tools for studying the function of DNA sequences, with an emphasis on those involved in the production of hemoglobin. It includes information about naturally-occurring human hemoglobin mutations and their effects, experimental data related to the regulation of the beta-like globin gene cluster, and software tools for comparing sequences with one another to discover regions that are likely to play significant roles. Images of models and results.

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Globin Gene Server home page

Welcome to the Globin Gene Server. This site provides data and tools for studying the function of DNA sequences, with an emphasis on those involved in the production of hemoglobin. It includes information about naturally-occurring human hemoglobin mutations and their effects, experimental data related to the regulation of the beta-like globin gene cluster, and software tools for comparing sequences with one another to discover regions that are likely to play significant roles. Images of models and results.

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