jolisfukyu.tokai-sc.jaea.go.jp
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6-5 難修復性DNA損傷収率の放射線のイオン化・励起密度依存性
http://jolisfukyu.tokai-sc.jaea.go.jp/fukyu/mirai/2007/6_5.html
イオン化 励起密度 LET の高い放射線が照射された場合には、数nm程度の領域に複数の損傷が同時に生成するクラスターDNA損傷が生じ a 、一方、LETが低い場合には、ランダムに孤立した状態 b で損傷が生じると考えられます。 グリコシラーゼの一種であるNthタンパク質によって生じた1本鎖切断頻度は、イオン化 励起密度 LET が高くなるにつれて大きく減少し、酵素の働きが阻害されて行くことが分かりました. 生体は土壌や宇宙など環境からの放射線に絶えずさらされ、その結果ゲノム DNA に化学的な構造変化 損傷 が高い頻度で生じていることが知られています。 最近、nm程度の狭い領域に複数の損傷が同時に生じる、クラスターDNA損傷 図6-11 a が提案されています。 しかし、これまでの分析化学的な方法で得られる損傷収率 線量当たりの損傷量 からは、実際に損傷がクラスター化しているかどうかについて知ることができません 図6-11。
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