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Structure Function Linkage Database

The SFLD is a database links evolutionarily related sequences and structures from mechanistically diverse superfamilies of enzymes to their chemical reactions.

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Structure Function Linkage Database | sfld.rbvi.ucsf.edu Reviews
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The SFLD is a database links evolutionarily related sequences and structures from mechanistically diverse superfamilies of enzymes to their chemical reactions.
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2 Structure Function Linkage Database
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5 reaction
6 structure
7 function
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about sfld,documentation ▾,glossary,evidence codes,networks,caveats,citing the sfld,sfld team,development,ucsf chimera,tutorials,curator's entrance,browse by superfamily,browse by reaction,search by enzyme,see the tutorials,for examples,or blast search
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Structure Function Linkage Database | sfld.rbvi.ucsf.edu Reviews

https://sfld.rbvi.ucsf.edu

The SFLD is a database links evolutionarily related sequences and structures from mechanistically diverse superfamilies of enzymes to their chemical reactions.

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1

SFLD - Sequence Similarity Networks

http://sfld.rbvi.ucsf.edu/django/web/networks

Sequence Similarity Networks in the SFLD. Network Definitions and Visualization. Files in Network Downloads. Node and Edge Attributes. Network Definitions and Visualization. Is an instantiation of the abstract data type called a graph. Which links individuals ( nodes. Through their connections ( edges. In a protein similarity network. Two types of SSNs are available from the SFLD:. One Sequence per Node (1SPN). Ndash; each node in the network represents a set of related protein sequences, and each edge r...

2

Tutorials

http://sfld.rbvi.ucsf.edu/django/web/tutorial_links

Using the Structure-Function Linkage Database. An Overview of the Structure-Function Linkage Database. Video, 6 mins). Using SFLD Search and Alignment Tools to Classify an Uncharacterized Enzyme. Video, 8 mins). Exploring Sequence Similarity Networks from the SFLD Using Cytoscape 3.x. Visualizing Sequence Relationships in Large Groups of Enzymes Using SFLD and Cytoscape 3.x. Video, 14 mins). Using Sequence Similarity Networks to Make Hypotheses Regarding Enzyme Function. Video, 9 mins). Video, 15 mins).

3

SFLD - Superfamily List

http://sfld.rbvi.ucsf.edu/django/superfamily

Isoprenoid Synthase Type I. Isoprenoid Synthase Type II. Radical SAM 3-amino-3-carboxypropyl Radical Forming. Radical SAM Phosphomethylpyrimidine Synthase. Radical SAM Phosphonate Metabolism. Babbitt Lab, SFLD Team.

4

SFLD - Evidence Codes

http://sfld.rbvi.ucsf.edu/django/web/ecodes

Sort by Evidence Code. The definition of evidence codes varies depending on the context. The following table lists the context and the definition of each evidence code in that context. Annotation in other databases. Annotation in other databases. MFR: Missing Functionally Important Residues. Used when a seqeuence is labeled as misannotated based upon the absence or mutation of residues known to be critical for the function to which the sequence was erroneously annotated. SFA: Superfamily Associated Only.

5

SFLD - Glossary

http://sfld.rbvi.ucsf.edu/django/web/glossary

The SFLD links to several external databases. Depending on the available information, a given sequence may link to its corresponding entry in one or more of the following:. Via accession.version number. Collection of non-redundant, well-annotated sequences. UniProtKB/SwissProt (the manually reviewed section of UniProt Knowledgebase. UniProtKB/TrEMBL (the unreviewed section of UniProt Knowledgebase. Integrated resource for comparative genomics of microbial species. RCSB Protein Data Bank. Representation o...

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RBVI Overview

http://rbvi.ucsf.edu/Overview/index.html

We distribute software tools. Including the popular UCSF Chimera. Visualization and analysis package, host the Structure-Function Linkage Database. And provide access to state-of-the-art computational resources. In support of research projects in these areas. Our Center's history dates back to the earliest application of molecular graphics. The RBVI is organized around five key activities:. Core research and development. Development and access to visualization resources.

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EMBL | Asad's Blog

https://chembioinfo.com/tag/embl

Man and his will to survive! ChemBLAST: Old dog new tricks. Asymp; 6 Comments. Has a rich page dedicate to the BLAST Tool. Bringing Chemistry in the BLAST. Calculate chemical fingerprints (binary:. For a given molecule for size length L. Choose the indexes in the L which are set to. For example, if bits 1, 10, 30, …. Are set as ‘. Now transform the indexes to char terminated by ‘$’ sign ( i.e 1- B$, 10- BA$, 30- DA$ …). Concatenate the patterns to form a sequence (B$BA$DA$…). I have used ECFP4. I have ch...

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chemaxon | Asad's Blog

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Man and his will to survive! ChemBLAST: Old dog new tricks. Asymp; 6 Comments. Has a rich page dedicate to the BLAST Tool. Bringing Chemistry in the BLAST. Calculate chemical fingerprints (binary:. For a given molecule for size length L. Choose the indexes in the L which are set to. For example, if bits 1, 10, 30, …. Are set as ‘. Now transform the indexes to char terminated by ‘$’ sign ( i.e 1- B$, 10- BA$, 30- DA$ …). Concatenate the patterns to form a sequence (B$BA$DA$…). I have used ECFP4. I have ch...

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ChEMBL | Asad's Blog

https://chembioinfo.com/tag/chembl

Man and his will to survive! ChemBLAST: Old dog new tricks. Asymp; 6 Comments. Has a rich page dedicate to the BLAST Tool. Bringing Chemistry in the BLAST. Calculate chemical fingerprints (binary:. For a given molecule for size length L. Choose the indexes in the L which are set to. For example, if bits 1, 10, 30, …. Are set as ‘. Now transform the indexes to char terminated by ‘$’ sign ( i.e 1- B$, 10- BA$, 30- DA$ …). Concatenate the patterns to form a sequence (B$BA$DA$…). I have used ECFP4. I have ch...

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EBI | Asad's Blog

https://chembioinfo.com/tag/ebi

Man and his will to survive! A Romance between Biology and Chemistry – Protein Sequences, Molecules and Enzyme function! Asymp; 3 Comments. NGS) data is knocking at our door and simultaneously, our ability to design novel enzymes. Rational design or directed evolution) using high throughput methods has improved tremendously. As a result, the demand to link enzymatic sequences to their chemical products and metabolic pathways is ever increasing. On the other hand, the push to generate Metabolomics. Predic...

kiemlicz.med.virginia.edu kiemlicz.med.virginia.edu

Enzyme Function Initiative - Pages

http://kiemlicz.med.virginia.edu/efi

Superfamilies: Targets and Structures. Ligands - full list. What is the EFI-DB? The EFI-DB serves as the EFI’s public database of experimental data. The database stores details of all cloning, purification, and structure determination experiments, as well as the results of in vivo and in vitro analyses as they become publicly available. The information is presented in a dynamic, interactive format to allow one to quickly browse through all experimental data. Targets with structures: 209. Download and vie...

babbittlab.ucsf.edu babbittlab.ucsf.edu

Babbitt Lab Members and Alumni

http://babbittlab.ucsf.edu/people.html

Lab Members and Alumni. Linking Sequence and Structure. California Institute for Quantitative Biosciences (QB3). University of California San Francisco. 1700 4th Street, 5th Floor. San Francisco, CA 94158. Patricia Babbitt, Ph.D. Shoshana Brown, Ph.D. Gemma Holliday, Ph.D. Assistant Researcher, SFLD. Ben Polacco, Ph.D. Elaine Meng, Ph.D. Eyal Akiva, Ph.D. Susan Mashiyama, Ph.D. Daniel Almonacid, Ph.D. Alex Schnoes, Ph.D. (2012). Michael Hicks, Ph.D. Alan Barber, Ph.D. Of the University of Hamburg.

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Babbitt Lab Resources

http://babbittlab.ucsf.edu/resources.html

Lab Members and Alumni. Linking Sequence and Structure. California Institute for Quantitative Biosciences (QB3). University of California San Francisco. 1700 4th Street, 5th Floor. San Francisco, CA 94158. The Structure Function Linkage Database:. A tool for the investigation of protein sequence, structure, and function. In particular, it aims to provide explicit information concerning how a given protein, or family of proteins, delivers chemical functionality. Atkinson HJ, Babbitt PC. An atlas of th...

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Structure Function Linkage Database

See description in Nucleic Acids Res. 2014 Jan 1; 42. What is the Structure-Function Linkage Database (SFLD)? A hierarchical classification of enzymes that relates specific sequence-structure features to specific chemical capabilities. A collection of tools and data for investigating sequence-structure-function relationships and hypothesizing function. How can I use the SFLD? Using Hidden Markov Models. Browse superfamilies in the SFLD. Search for a specific enzyme. View structures in Chimera.

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Welcome to the Sherwood Forest Lake District | Sherwood Forest Lake District

Sherwood Forest Lake District. Agenda, minutes, and notices on this site are for informational purposes only. APPROVED BUDGET FY2013 FINAL. 2013 SFLD By-Laws dtd 8 Jun 2013 As AmendedcFINAL.pdf. Committee on Boats and Beaches. 2012 SFLD DISTRICT REPORTd. Meeting Minutes FY 2010-2013. 2012 August 11 Minutes Final.pdf. 2012 July 7 Minutes DRAFTa. 2012 JUNE Special Meeting WarrantD SIGNED. 2012 June 30 Minutes DRAFT. 2012 JUNE Annual Meeting Warrant D4 SIGNED. 2011 April 9 Minutes FINAL. OPT OUT FORM FY2012.

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Grupo de Danças de Salão da SFL. Fernando, Rita, Alberto e Bárbara. 1º e 4º lugares Novice C. Sarau de Ginástica e Dança 2008. Realizou-se no dia 20 de Junho de 2008, no Pavilhão da Escola E. B. 2, 3 da Lousã o SARAU DE GINÁSTICA E DANÇA. O grupo de Danças de Salão da S. Filarmónica Lousanense em conjunto com o grupo de Desporto Escolar teve uma participação brilhante num evento cheio de cor e alegria. Entre muitas vantagens, podemos destacar:. Desenvolve a coordenação mental e motora;.

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