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Small Molecule | Preclinical Toxicology CRO | GLP| Non-GLP

Drik, a preclinical toxicology CRO, Best If You Need-Undivided Attention;Cost Certainty;Assay by PhD; Seamless Transition. At Drik, we believe the future of your discovery depends on its present safety testing.

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Small Molecule | Preclinical Toxicology CRO | GLP| Non-GLP | atdrik.com Reviews

https://atdrik.com

Drik, a preclinical toxicology CRO, Best If You Need-Undivided Attention;Cost Certainty;Assay by PhD; Seamless Transition. At Drik, we believe the future of your discovery depends on its present safety testing.

INTERNAL PAGES

atdrik.com atdrik.com
1

LIVER - Drik

http://www.atdrik.com/liver

QUALITY & REGULATORY. NEWS & EVENTS. In Vitro toxicity assay in cell lines. Most common service we provide in the cell lines are. Apotosis assay (Caspase 2,3,6,7,8 and 9 assay). Toxicity study with primary culture of human and animal hepatocytes and also in induced pluripotent stem cells (IPSC). To understand mechanism of action, the following assay end points are offered by Drik:. CYP inhibition; DDI. Apoptosis (Casp3/7/8/9), BrDU. GSH; Oxygen radical absorbance. Mission Vision and Values.

2

IN SILICO - Drik

http://www.atdrik.com/in-silico

QUALITY & REGULATORY. NEWS & EVENTS. In Silico approaches help in determination of toxic liability of a pharmacophore. In collaboration with Leadscope. Database currently used by FDA. we help clients to determine the toxicity profile of compound/s. Please contact us info@atdrik.com. To have more information. Mission Vision and Values. Oklahoma City, OK, 73104-3609. Lets talk to a Scientist. 2014 DRIK LLC All right reserved. Privacy and Policy/ Terms and Condition.

3

Blog - Drik

http://www.atdrik.com/blog

QUALITY & REGULATORY. NEWS & EVENTS. Mission Vision and Values. Oklahoma City, OK, 73104-3609. Lets talk to a Scientist. 2014 DRIK LLC All right reserved. Privacy and Policy/ Terms and Condition.

4

SERVICES - Drik

http://www.atdrik.com/services

QUALITY & REGULATORY. NEWS & EVENTS. PK/PD study in rodents and dogs. Short term and long term toxicity studies. Drug induced Liver, Kidney and cardiac toxicity. Cardiotoxicity hERG Screening in Guinea Pigs. 3D Slice culture (also known as organ culture) model. Drug-Drug interactions (P450 inhibition, CYP inhibition). Blood Chemistry, Clinical Pathology. Mission Vision and Values. Oklahoma City, OK, 73104-3609. Lets talk to a Scientist. 2014 DRIK LLC All right reserved.

5

KIDNEY - Drik

http://www.atdrik.com/kidney

QUALITY & REGULATORY. NEWS & EVENTS. Most drugs found to cause nephrotoxicity exert toxic effects by one or more common pathogenic mechanisms. These include altered intraglomerular hemodynamics, tubular cell toxicity, inflammation, crystal nephropathy, rhabdomyolysis, and thrombotic microan-giopathy. Several possible drug-induced kidney biomarkers are under investigation. KIM-1, urinary IL-18, TFF3, urinary NAG, urinary GST-alpha, urinary NGAL. Pre-clinical Kidney: Phase I. CYP inhibition; DDI.

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