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bugbearsncbs | A fine WordPress.com site

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Viruses turn the tables on their bacterial hosts | bugbearsncbs

https://bugbearsncbs.wordpress.com/2013/03/18/viruses-turn-the-tables-on-their-bacterial-hosts

A fine WordPress.com site. The promoter-search mechanism of Escherichia coli RNA polymerase is dominated by three-dimensional diffusion. Precarious balance of genome stability →. Viruses turn the tables on their bacterial hosts. These spacer sequences are identical to sequences present in phage DNA. They are transcribed into small RNA molecules called crRNAs, which, with the help of the Cas proteins, bind to and cause degradation of the invading phage DNA. However, a recent study. The authors demonstrate...

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aalapm | bugbearsncbs

https://bugbearsncbs.wordpress.com/author/aalapm

A fine WordPress.com site. The promoter-search mechanism of Escherichia coli RNA polymerase is dominated by three-dimensional diffusion. The authors of this recently published paper in nature structural and molecular biology ( http:/ www.nature.com/nsmb/journal/v20/n2/full/nsmb.2472.html. Provide many arguments against contribution of facilitated diffusion (1D hopping/sliding along the DNA) as a promoter search mechanism for Escherichia coli. Tagged promoter search mechanism. Employed an improvement on a...

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Promiscuous restriction is a cellular defense strategy that confers fitness advantage to bacteria | bugbearsncbs

https://bugbearsncbs.wordpress.com/2012/12/17/promiscuous-restriction-is-a-cellular-defense-strategy-that-confers-fitness-advantage-to-bacteria

A fine WordPress.com site. Bacteria Cooperate to Survive Overcrowding. Sirturo : A novel anti-Mycobacterium antibiotic after 40 years., →. Promiscuous restriction is a cellular defense strategy that confers fitness advantage to bacteria. Carried by a group of scientists at IISC. Even though the RM system in bacteria is stringent, the phages evade the defense statergy employed by the bacterium, by various means. In order to cope up with the phages defense mechanism, the bacterium has to counteract the...

4

revathyk | bugbearsncbs

https://bugbearsncbs.wordpress.com/author/revathyk

A fine WordPress.com site. Sirturo : A novel anti-Mycobacterium antibiotic after 40 years.,. Sirturo (bedaquiline) – a diarylquinalone – acts against Mycobacterium and it is approved by FDA by December 2012. Report claims that the approval is based on phase 2 clinical trial with 394 patients. Its acts by inhibiting the Mycobacterial F. Adenosine triphosphate (ATP) synthase – this MoA is novel among other anti tuberculosis drug. For more information please visit the report by Randy Osborne. The authors pr...

5

Precarious balance of genome stability | bugbearsncbs

https://bugbearsncbs.wordpress.com/2013/12/06/precarious-balance-of-genome-stability

A fine WordPress.com site. Viruses turn the tables on their bacterial hosts. Precarious balance of genome stability. Living organisms adapt to altered environments by the stepwise selection of genomic changes that lead to the optimization of fitness under the altered conditions. Conversely, what would happen if one tinkers with the genome while outside conditions remain more or less unaltered? Deleting an apparently, non-essential gene might not threaten survival under laboratory conditions but is likely...

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bugbearsncbs | A fine WordPress.com site

A fine WordPress.com site. Precarious balance of genome stability. Living organisms adapt to altered environments by the stepwise selection of genomic changes that lead to the optimization of fitness under the altered conditions. Conversely, what would happen if one tinkers with the genome while outside conditions remain more or less unaltered? Deleting an apparently, non-essential gene might not threaten survival under laboratory conditions but is likely to lead to a reduction in fitness under specific ...

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