califano.c2b2.columbia.edu

Andrea Califano

Laboratory of Systems Biology. Our laboratory uses systems biology principles. To elucidate and then investigate cell regulatory networks. We are particularly interested in applying this perspective to understand cancer tumorigenesis, drug resistance, and cellular heterogeneity. And are working with clinical researchers at Columbia University Medical Center to conduct N-of-1 clinical trials for precision cancer medicine. Dec 15, 2016. Dec 15, 2016. Dec 15, 2016. Dec 15, 2016. Dec 15, 2016. Dec 15, 2016.

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Andrea Califano | califano.c2b2.columbia.edu Reviews

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Laboratory of Systems Biology. Our laboratory uses systems biology principles. To elucidate and then investigate cell regulatory networks. We are particularly interested in applying this perspective to understand cancer tumorigenesis, drug resistance, and cellular heterogeneity. And are working with clinical researchers at Columbia University Medical Center to conduct N-of-1 clinical trials for precision cancer medicine. Dec 15, 2016. Dec 15, 2016. Dec 15, 2016. Dec 15, 2016. Dec 15, 2016. Dec 15, 2016.

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Andrea Califano | califano.c2b2.columbia.edu Reviews

https://califano.c2b2.columbia.edu

Laboratory of Systems Biology. Our laboratory uses systems biology principles. To elucidate and then investigate cell regulatory networks. We are particularly interested in applying this perspective to understand cancer tumorigenesis, drug resistance, and cellular heterogeneity. And are working with clinical researchers at Columbia University Medical Center to conduct N-of-1 clinical trials for precision cancer medicine. Dec 15, 2016. Dec 15, 2016. Dec 15, 2016. Dec 15, 2016. Dec 15, 2016. Dec 15, 2016.

INTERNAL PAGES

califano.c2b2.columbia.edu

1

Drug Synergy and Mechanism of Action — Andrea Califano

http://califano.c2b2.columbia.edu/drug-synergy-mechanism-of-action

Laboratory of Systems Biology. Drug Synergy and Mechanism of Action. By analyzing drug-induced changes in disease-specific patterns of gene expression, a new algorithm called DeMAND identifies the genes involved in implementing a drug's effects. The method could help predict undesirable off-target interactions, suggest ways of regulating a drug's activity, and identify novel therapeutic uses for FDA-approved drugs, three critical challenges in drug development. Our laboratory has demonstrated that the ne...

2

N-of-1 Clinical Trials and Precision Medicine — Andrea Califano

http://califano.c2b2.columbia.edu/n-of-1-clinical-trials-precision-medicine-cancer

Laboratory of Systems Biology. N-of-1 Clinical Trials and Precision Medicine for Cancer. Schematic of our approach to N-of-1 cancer clinical trials. Our goal is to identify existing FDA-approved and investigational compounds that could quickly be tested for effectiveness in blocking master regulators responsible for tumor maintenance. As our lab’s research has shown, network-based approaches. Using systems biology for precision medicine. Traditional clinical trials investigate whether a particular diagno...

3

People — Andrea Califano

http://califano.c2b2.columbia.edu/people

Laboratory of Systems Biology. Clyde and Helen Wu Professor of Chemical Systems Biology. Chair, Department of Systems Biology. Director, JP Sulzberger Columbia Genome Center. Associate Director, Herbert Irving Comprehensive Cancer Center. Executive Director and Scientific Operations Manager. Graduate Student (joint with Honig Lab). Medical Student (PhD-to-MD program). Medical Oncology Clinical Fellow. Chief Scientific Officer, DarwinHealth. Ferrando Lab, Columbia University. Vice President, Psychogenics.

4

Openings — Andrea Califano

http://califano.c2b2.columbia.edu/openings

Laboratory of Systems Biology. Send resume to: Andrea Califano at ac2248@cumc.columbia.edu AA/EOE. Students currently enrolled within a Master's or PhD program at the Center for Computational Biology and Bioinformatics (C2B2) or within the Department of Biomedical Informatics (DBMI) may further their educational pursuits by becoming a member of Dr. Califano's lab. Califano Laboratory of Systems Biology. Columbia University Medical Center. Herbert Irving Cancer Research Center. 1130 St. Nicholas Avenue.

5

Software — Andrea Califano

http://califano.c2b2.columbia.edu/software

Laboratory of Systems Biology. ARACNe (Algorithm for the Reconstruction of Accurate Cellular Networks) is a novel algorithm, using microarray expression profiles, specifically designed to scale up to the complexity of regulatory networks in mammalian cells, yet general enough to address a wider range of network deconvolution problems. This method uses an information theoretic approach to eliminate the vast majority of indirect interactions typically inferred by pairwise analysis. MATLAB functions for pre...

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전산생물학, 생물정보학 논문의 정석(?) -(VIPER by andrea califano) – pioinfo

https://pioinfo.wordpress.com/2016/06/28/viper-by-andrea-califano-전산생물학-생물정보학-논문의-정석/comment-page-1

암의 진화2] 지금은 맞고 그때는 틀리다? 전산생물학, 생물정보학 논문의 정석(? VIPER by andrea califano). 브렉시트 (Brexit) 즈음에서 보면 좋을 TED 강연들. 2016년 4 5월 재밌는 TED 강연. 암의 진화1] 암의 진화생물학. 의 (암의 진화) 지금은 맞고 그때는 틀…. 전산생물학, 생물정보학 논문의 정석(? 암의 진화1] 암의 진화생물학. 전산생물학, 생물정보학 논문의 정석(? VIPER by andrea califano). 이번에 리뷰하는 논문은 컬럼비아(Columbia)대학의 칼리파노( Andrea califano. 무려 Nature Genetics, 2016년 6월 20일) ‘ VIPER. 이다 원제목은 “ Functional characterization of somatic mutations in cancer using network-based inference of protein activity. 주의) 이번 글은 독후감에 가깝습니다. 의 비중이 다 ...

pioinfo.wordpress.com

2016 6월 – pioinfo

https://pioinfo.wordpress.com/2016/06

암의 진화2] 지금은 맞고 그때는 틀리다? 전산생물학, 생물정보학 논문의 정석(? VIPER by andrea califano). 브렉시트 (Brexit) 즈음에서 보면 좋을 TED 강연들. 2016년 4 5월 재밌는 TED 강연. 암의 진화1] 암의 진화생물학. 의 (암의 진화) 지금은 맞고 그때는 틀…. 전산생물학, 생물정보학 논문의 정석(? 암의 진화1] 암의 진화생물학. 전산생물학, 생물정보학 논문의 정석(? VIPER by andrea califano). 이번에 리뷰하는 논문은 컬럼비아(Columbia)대학의 칼리파노( Andrea califano. 무려 Nature Genetics, 2016년 6월 20일) ‘ VIPER. 이다 원제목은 “ Functional characterization of somatic mutations in cancer using network-based inference of protein activity. 주의) 이번 글은 독후감에 가깝습니다. 의 비중이 다 ...

pioinfo.wordpress.com

전산생물학, 생물정보학 논문의 정석(?) -(VIPER by andrea califano) – pioinfo

https://pioinfo.wordpress.com/2016/06/28/viper-by-andrea-califano-전산생물학-생물정보학-논문의-정석

암의 진화2] 지금은 맞고 그때는 틀리다? 전산생물학, 생물정보학 논문의 정석(? VIPER by andrea califano). 브렉시트 (Brexit) 즈음에서 보면 좋을 TED 강연들. 2016년 4 5월 재밌는 TED 강연. 암의 진화1] 암의 진화생물학. 의 (암의 진화) 지금은 맞고 그때는 틀…. 전산생물학, 생물정보학 논문의 정석(? 암의 진화1] 암의 진화생물학. 전산생물학, 생물정보학 논문의 정석(? VIPER by andrea califano). 이번에 리뷰하는 논문은 컬럼비아(Columbia)대학의 칼리파노( Andrea califano. 무려 Nature Genetics, 2016년 6월 20일) ‘ VIPER. 이다 원제목은 “ Functional characterization of somatic mutations in cancer using network-based inference of protein activity. 주의) 이번 글은 독후감에 가깝습니다. 의 비중이 다 ...

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Andrea Califano

Laboratory of Systems Biology. Our laboratory uses systems biology principles. To elucidate and then investigate cell regulatory networks. We are particularly interested in applying this perspective to understand cancer tumorigenesis, drug resistance, and cellular heterogeneity. And are working with clinical researchers at Columbia University Medical Center to conduct N-of-1 clinical trials for precision cancer medicine. Dec 15, 2016. Dec 15, 2016. Dec 15, 2016. Dec 15, 2016. Dec 15, 2016. Dec 15, 2016.

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