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The Pearson Lab studies the molecular mechanisms involved in genetic mutations in trinucleotide repeat sequences. Instability (i.e., expansions) of trinucleotide repeats are responsible for numerous neurological, neurodegenerative, and neuromuscular disorders including myotonic dystrophy (the most common form of muscular dystrophy), Huntington's disease and fragile X syndrome (the most common form of inherited mental retardation). Our research focus is identifying. Pearson Lab publishes findings!

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The Pearson Lab studies the molecular mechanisms involved in genetic mutations in trinucleotide repeat sequences. Instability (i.e., expansions) of trinucleotide repeats are responsible for numerous neurological, neurodegenerative, and neuromuscular disorders including myotonic dystrophy (the most common form of muscular dystrophy), Huntington's disease and fragile X syndrome (the most common form of inherited mental retardation). Our research focus is identifying. Pearson Lab publishes findings!
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Pearson Lab - Home | cepearsonlab.com Reviews

https://cepearsonlab.com

The Pearson Lab studies the molecular mechanisms involved in genetic mutations in trinucleotide repeat sequences. Instability (i.e., expansions) of trinucleotide repeats are responsible for numerous neurological, neurodegenerative, and neuromuscular disorders including myotonic dystrophy (the most common form of muscular dystrophy), Huntington's disease and fragile X syndrome (the most common form of inherited mental retardation). Our research focus is identifying. Pearson Lab publishes findings!

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Pearson Lab - Photos

http://www.cepearsonlab.com/photos.php

MaRS - TMDT 2007. From left to right: Christopher, Arturo, Isabel, Meghan, Aida, Michelle, Katharine, Victoria, John, Rachel, Gagan, Kaalak). Our Lab at SickKids. From left to right: Katharine, Kerrie, Rachel, John, Stephanie, Christopher). From left to right: Katharine, John, Mariana, Michelle, Rachel, Gagan, Christopher). 5th International Conference on Unstable Microsatellites and Human Disease,. Granada, Spain Nov 2006. The Organizers (Laura Ranum, Christopher Pearson, Albert La Spada).

2

Pearson Lab - Repeat Disease Database

http://www.cepearsonlab.com/rdd.php

This collection of repeat-associated diseases and trans. Factors associated with repeat instability is meant to be a dynamic database, always growing and ever changing. As such we welcome your comments and suggestions on either list. Please feel free to regularly update us. On any new repeat-associated diseases and trans. Factors that you come across in your research or in scientific literature. Factors associated with repeat instability.

3

Pearson Lab - Staff

http://www.cepearsonlab.com/staff.php

Post-docs are independently involved implementing, maintaining and directing a comprehensive research project while writing manuscripts and aiding in directing the research focus of the lab. Post-docs are responsible for presenting at conferences, departmental seminars and journal club. Independently designs, plans, organizes and implements laboratory research projects. Remains currents on research of current principles and theories.Often serves as an internal consultant. Designs lay-out and ...

4

Pearson Lab - Publications

http://www.cepearsonlab.com/publications.php

Pubmed Search for Dr. CE Pearson. Martins S, Pearson CE, Coutinho P, Provost S, Amorim A, Dub MP, Sequeiros J, Rouleau GA. Modifiers of (CAG)n instability in Machado-Joseph disease (MJD/SCA3) transmissions: an association study with DNA replication, repair and recombination genes. Reddy K, Schmidt MH, Geist JM, Thakkar NP, Panigrahi GB, Wang YH, Pearson CE. Processing of double-R-loops in (CAG)(CTG) and C9orf72 (GGGGCC)(GGCCCC) repeats causes instability. 2014 Mar 15;23(6):1606-18. Pinto RM, Dragileva E,...

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Pearson Lab - About Dr. Pearson

http://www.cepearsonlab.com/pearson.php

Christopher E. Pearson. Our research focuses on the mechanisms and factors (cellular and genetic) that regulate the genetic instability of trinucleotide repeats. Mutations in tandemly repeated sequences may occur either during the process of DNA replication (genome duplication) or as a result of error-prone DNA repair or through DNA recombination. Intellectual Property / Licensing Opportunities. Methylation of Unstable Sequences.

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Wilson Lab

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Liis completed her PhD in reproductive genetics and epigenetics with Dr. Maris Laan at the University of Tartu, Estonia. Huayun is a graduate student in Molecular Genetics at UofT. She did her undergrad at Peking University. Xuefei is a graduate student in Molecular Genetics at UofT and is co-supervised with Dr. Ian Scott. She did her undergrad at Peking University. Minggao is a graduate student in Molecular Genetics at UofT. He did his undergrad at UofT. 4th year undergraduate student. Alejandra complet...

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Pearson Lab - Home

The Pearson Lab studies the molecular mechanisms involved in genetic mutations in trinucleotide repeat sequences. Instability (i.e., expansions) of trinucleotide repeats are responsible for numerous neurological, neurodegenerative, and neuromuscular disorders including myotonic dystrophy (the most common form of muscular dystrophy), Huntington's disease and fragile X syndrome (the most common form of inherited mental retardation). Our research focus is identifying. Pearson Lab publishes findings!

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