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CHROMus | Cornell Heart Lung Blood Resource for Optogenetic Mouse Signaling

Cornell Heart Lung Blood Resource for Optogenetic Mouse Signaling. Developing and distributing transgenic mice to examine cell signaling in the cardiac, vascular, pulmonary and immune systems. HeLa cells expressing GCaMP in the ER and a cytoplasmic mCherry. Arteriolar endothelial cell expression of GCAMP2. Cholinergic nerves expressing EGFP in lung, stomach and intestine. Cardiac expression of GCaMP2 during contraction. The Cornell Heart Lung Blood Resource for Optogenetic Mouse Signaling (. Once created...

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CHROMus | Cornell Heart Lung Blood Resource for Optogenetic Mouse Signaling | chromus.vet.cornell.edu Reviews

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Cornell Heart Lung Blood Resource for Optogenetic Mouse Signaling. Developing and distributing transgenic mice to examine cell signaling in the cardiac, vascular, pulmonary and immune systems. HeLa cells expressing GCaMP in the ER and a cytoplasmic mCherry. Arteriolar endothelial cell expression of GCAMP2. Cholinergic nerves expressing EGFP in lung, stomach and intestine. Cardiac expression of GCaMP2 during contraction. The Cornell Heart Lung Blood Resource for Optogenetic Mouse Signaling (. Once created...

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CHROMus | Cornell Heart Lung Blood Resource for Optogenetic Mouse Signaling | chromus.vet.cornell.edu Reviews

https://chromus.vet.cornell.edu

Cornell Heart Lung Blood Resource for Optogenetic Mouse Signaling. Developing and distributing transgenic mice to examine cell signaling in the cardiac, vascular, pulmonary and immune systems. HeLa cells expressing GCaMP in the ER and a cytoplasmic mCherry. Arteriolar endothelial cell expression of GCAMP2. Cholinergic nerves expressing EGFP in lung, stomach and intestine. Cardiac expression of GCaMP2 during contraction. The Cornell Heart Lung Blood Resource for Optogenetic Mouse Signaling (. Once created...

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chromus.vet.cornell.edu

1

Publications – CHROMus

http://chromus.vet.cornell.edu/publications

Cornell Heart Lung Blood Resource for Optogenetic Mouse Signaling. Shui B, Lee JC, Reining S, Lee FK, Kotlikoff MI. CHROMus: the Cornell/National Heart Lung Blood Institute Resource for optogenetic mice. Front. Physiol., 06 November 2014 doi: 10.3389/fphys.2014.00428. Genetically Encoded Calcium Indicators:. Wang Q, Shui B, Kotlikoff MI, Sondermann H. Structural basis for calcium sensing by GCaMP2. Structure. 2008 Dec 10;16(12):1817-27. Kleinlogel S, Feldbauer K, Dempski RE, Fotis H, Wood PG, Bamann C, B...

2

Mouse Production – CHROMus

http://chromus.vet.cornell.edu/mouse-production

Cornell Heart Lung Blood Resource for Optogenetic Mouse Signaling. Click on any tissue system or line for more details). For details on the construction of transgenes, click here. Cardiac and venous system. ΑMHC, HCN4 and Cdh5 promoters):. DBH, ChAT and gfap promoters):. Pdpn, SP-C, FoxJ1 and CCSP promoters):. Previously developed in the Kotlikoff Laboratory. Suggest a new line! Cardiac and Venous system. Genetically encoded calcium indicators (GECIs). Rhodopsin based Optogenetic Tools.

3

Our Mission: – CHROMus

http://chromus.vet.cornell.edu/2014/08/03/our-mission

Cornell Heart Lung Blood Resource for Optogenetic Mouse Signaling. The Cornell Heart Lung Blood Resource for Optogenetic Mouse Signaling (. Is directed by Dr. Michael Kotlikoff, Cornell University. A Steering Committee consisting of eleven additional world renowned scientists expert in the fields of cardiac, vascular, lung and immuno biology as well as in fluorescent protein design, optogenetics and gene targeting will meet bi-annually to prioritize and review mouse lines. August 3, 2014 at 11:58 pm.

4

Links of Interest – CHROMus

http://chromus.vet.cornell.edu/links-of-interest

Cornell Heart Lung Blood Resource for Optogenetic Mouse Signaling. Cornell University, College of Veterinary Medicine in the foreground. Cornell University College of Veterinary Medicine. Department of Biomedical Sciences. Cornell Induced Pluripotent Stem Cell Core Laboratory. UC Irvine Transgenic Mouse Facility. The GENSAT Project at The Rockefeller University. Ithaca Falls on Fall Creek. Suggest a new line! Cardiac and Venous system. Genetically encoded calcium indicators (GECIs).

5

Why CHROMus? – CHROMus

http://chromus.vet.cornell.edu/why-chromus

Cornell Heart Lung Blood Resource for Optogenetic Mouse Signaling. Physiological processes involve dynamic and highly specific cell signaling occurring on a millisecond time scale and largely undetectable in real time through scientific observation. The advent of green fluorescent protein (GFP) and other optical molecules stably expressed under cell-specific transcriptional control in genetically modified organisms has ushered in a new era of in vivo. Genetically encoded calcium indicators (GECIs):.

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CHROMus | Cornell Heart Lung Blood Resource for Optogenetic Mouse Signaling

Cornell Heart Lung Blood Resource for Optogenetic Mouse Signaling. Developing and distributing transgenic mice to examine cell signaling in the cardiac, vascular, pulmonary and immune systems. HeLa cells expressing GCaMP in the ER and a cytoplasmic mCherry. Arteriolar endothelial cell expression of GCAMP2. Cholinergic nerves expressing EGFP in lung, stomach and intestine. Cardiac expression of GCaMP2 during contraction. The Cornell Heart Lung Blood Resource for Optogenetic Mouse Signaling (. Once created...

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