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CK GenesCK's views on genes, genetics, health and topics of interest...
http://ckgenes.blogspot.com/
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http://ckgenes.blogspot.com/
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CK Genes | ckgenes.blogspot.com Reviews
https://ckgenes.blogspot.com
CK's views on genes, genetics, health and topics of interest...
ckgenes.blogspot.com
CK Genes: September 2008
http://ckgenes.blogspot.com/2008_09_01_archive.html
CK's views on genes, genetics, health and topics of interest. Wednesday, September 24, 2008. ANRIL, Chromosome 9p21 and Coronary Artery Disease. I had just attended a talk by Dr Ruth McPherson. On the topic of “Genetic Insights into Coronary Artery Disease”. She spoke about her genomewide association study (GWAS) which she had recently published in Science. For a quick review of the recent developments in GWAS of CAD, you can refer to my editorial. In the European Heart Journal. I saw a few clusters of t...
CK Genes: More genomic markers identified for heart attack and coronary artery disease. Surprised?
http://ckgenes.blogspot.com/2009/03/more-genomic-markers-identified-for.html
CK's views on genes, genetics, health and topics of interest. Sunday, March 1, 2009. More genomic markers identified for heart attack and coronary artery disease. Surprised? Time really flies by so quickly! I have just noted that my last posting was done more than two months ago! In the first paper. In the second study. Probably the most surprising of these is the report. I supposed Dr Eric Topol MD, from the Scripps School of Medicine best sums it up by saying that "there are several pathways that set u...
CK Genes: Take a genetic test first before you take your weight-loss drugs?
http://ckgenes.blogspot.com/2008/10/take-genetic-test-first-before-you-take.html
CK's views on genes, genetics, health and topics of interest. Tuesday, October 7, 2008. Take a genetic test first before you take your weight-loss drugs? ScienceDaily (Oct. 2, 2008) — Obese patients with a specific genetic make-up lose more weight when taking the weight loss drug sibutramine and undergoing behavioral therapy compared to those without this genetic make-up, reports a new study in Gastroenterology. The official journal of the American Gastroenterological Association (AGA) Institute. Study r...
CK Genes: Advantages of using sunflower oil, corn oil, canola oil, soybean oil, and olive oil
http://ckgenes.blogspot.com/2008/10/advantages-of-using-sunflower-oil-corn.html
CK's views on genes, genetics, health and topics of interest. Thursday, October 9, 2008. Advantages of using sunflower oil, corn oil, canola oil, soybean oil, and olive oil. In the latest issue of the American Journal of Clinical Nutrition, it is reported that the consumption of partially hydrogenated vegetable oils (PHVO) [click to see what is meant by this]. So the take home point is: use non-hydrogenated vegetable oils! Ahmad Esmaillzadeh and Leila Azadbakht. Background: Most knowledge about adverse h...
CK Genes: Pfizer to drop development of drugs for hyperlipidemia, atherosclerosis, and heart failure
http://ckgenes.blogspot.com/2008/10/pfizer-to-drop-development-of-drugs-for.html
CK's views on genes, genetics, health and topics of interest. Tuesday, October 14, 2008. Pfizer to drop development of drugs for hyperlipidemia, atherosclerosis, and heart failure. Pfizer to drop development of drugs for hyperlipidemia, atherosclerosis, and heart failure. October 2, 2008. New York, NY - Pfizer is getting out of the cholesterol-lowering game to focus on what it perceives to be more lucrative diseases, according to an internal memo obtained by Forbes [ 1. Subscribe to: Post Comments (Atom).
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pganddrugresponse.blogspot.com
Pharmacogenetics and Variability in Drug Response: June 2009
http://pganddrugresponse.blogspot.com/2009_06_01_archive.html
8220;The things we hate about ourselves aren't more real than things we like about ourselves.” Ellen Goodman. Monday, June 15, 2009. The CYP4F2 is involved in the synthesis of a number of sterols and lipids. Because it was involved in the production of 20-hydroxyeicosatetraenoic acid (20-HETE), it was postulated to be involved in the pathophysiology of hypertension. It is now thought to be also involved in the. Breakdown of Vit K1. PharmacoGenetics and Variability in Drug Response. Edmund J.D. Lee. Pharm...
pganddrugresponse.blogspot.com
Pharmacogenetics and Variability in Drug Response: The issue of clarithromycin and increased cardiac deaths
http://pganddrugresponse.blogspot.com/2014/08/the-issue-of-clarithromycin-and.html
8220;The things we hate about ourselves aren't more real than things we like about ourselves.” Ellen Goodman. Friday, August 22, 2014. The issue of clarithromycin and increased cardiac deaths. Just this last week I was discussing with my students, the various factors contributing to variable drug response. And possible differences in the risk-benefit ratios for the same drug in different individuals. The recent publicity about increased cardiac death risks associated with clarithromycin. Pharmacogenetics...
pganddrugresponse.blogspot.com
Pharmacogenetics and Variability in Drug Response: October 2011
http://pganddrugresponse.blogspot.com/2011_10_01_archive.html
8220;The things we hate about ourselves aren't more real than things we like about ourselves.” Ellen Goodman. Friday, October 21, 2011. Stress - Nature vs Nurture: Lessons for drug response variability. This has been abstracted from Darlene Francis and Daniela Kaufer's essay in Reading Frames: The Scientist October 2011. Scientists and laymen alike still spend too much time and effort trying to quantify the relative importance of nature and nurture. PharmacoGenetics and Variability in Drug Response.
pganddrugresponse.blogspot.com
Pharmacogenetics and Variability in Drug Response: October 2010
http://pganddrugresponse.blogspot.com/2010_10_01_archive.html
8220;The things we hate about ourselves aren't more real than things we like about ourselves.” Ellen Goodman. Sunday, October 31, 2010. Many people agonize about the predictivity of the science of pharmacogenetics. Somehow there is an expectation that pharmacogenetics should somehow lead to position where we can stop thinking. Sounds a bit harsh but true. Pharmacogenetics began as a science. Or HLA B*1502 for carbamazepine-SJS. FDA classification: , for information only; , recommended; , required. This l...
pganddrugresponse.blogspot.com
Pharmacogenetics and Variability in Drug Response: Pharmacogenetics-Pharmacogenomics-Personalized Medicine
http://pganddrugresponse.blogspot.com/2011/11/pharmacogenetics-pharmacogenomics.html
8220;The things we hate about ourselves aren't more real than things we like about ourselves.” Ellen Goodman. Sunday, November 20, 2011. The latest plot of numbers of publications suing the terms 'Pharmacogenetics', 'Pharmacogenomics', and 'Personalized Medicine'. (see previous plot). Perhaps P'genomics should be considered a subset of P'genetics rather than what has often conversely been suggested. PharmacoGenetics and Variability in Drug Response. Subscribe to: Post Comments (Atom). Pharmacogenetics et...
pganddrugresponse.blogspot.com
Pharmacogenetics and Variability in Drug Response: August 2011
http://pganddrugresponse.blogspot.com/2011_08_01_archive.html
8220;The things we hate about ourselves aren't more real than things we like about ourselves.” Ellen Goodman. Monday, August 22, 2011. Bridging the efficacy–effectiveness gap. Bridging the efficacy–effectiveness gap: a regulator's perspective on addressing variability of drug response. Hans-Georg Eichler, Eric Abadie, Alasdair Breckenridge, Bruno Flamion, Lars L. Gustafsson, Hubert Leufkens, Malcolm Rowland, Christian K. Schneider and Brigitte Bloechl-Daum. Looking at PK data #2. Sunday, August 21, 2011.
pganddrugresponse.blogspot.com
Pharmacogenetics and Variability in Drug Response: November 2011
http://pganddrugresponse.blogspot.com/2011_11_01_archive.html
8220;The things we hate about ourselves aren't more real than things we like about ourselves.” Ellen Goodman. Sunday, November 20, 2011. The latest plot of numbers of publications suing the terms 'Pharmacogenetics', 'Pharmacogenomics', and 'Personalized Medicine'. (see previous plot). Perhaps P'genomics should be considered a subset of P'genetics rather than what has often conversely been suggested. PharmacoGenetics and Variability in Drug Response. Friday, November 18, 2011. Blood-brain barrier (BBB), f...
pganddrugresponse.blogspot.com
Pharmacogenetics and Variability in Drug Response: September 2010
http://pganddrugresponse.blogspot.com/2010_09_01_archive.html
8220;The things we hate about ourselves aren't more real than things we like about ourselves.” Ellen Goodman. Wednesday, September 29, 2010. Clopidogrel - variability in response. Indian Heart Journal. 2008 Nov-Dec; 60(6): 543-7. The use of clopidogrel presents another interesting challenge with respect to the variability in drug response. A) high first pass and low active metabolite bioavailability. B) variability of CYP3A4 and CYP2C19 activities due to pharmacogenetics and food/drug interactions. Drug ...
pganddrugresponse.blogspot.com
Pharmacogenetics and Variability in Drug Response: The issue of clarithromycin and increased cardiac deaths #2 - Pharmacology
http://pganddrugresponse.blogspot.com/2014/08/the-issue-of-clarithromycin-and_22.html
8220;The things we hate about ourselves aren't more real than things we like about ourselves.” Ellen Goodman. Friday, August 22, 2014. The issue of clarithromycin and increased cardiac deaths #2 - Pharmacology. Clarithromycin is a macrolide bacteriostatic antimicrobial that came onto the market in 1991. It enjoyed considerable success as an orally administrable macrolide, being relatively lipophilic and having a slightly longer elimination half-life. Came off patent about 10 years ago. Clarithromycin is ...
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CK Genes
CK's views on genes, genetics, health and topics of interest. Monday, June 8, 2009. Watch how long you sit! I recently blogged about the relationship between lack of sleep and disease. Now it looks like a group of investigators in Canada has found some evidence linking sitting time and various chronic diseases. The paper was published recently in the. Medicine and Science in Sports and Exercise journal. Monday, March 2, 2009. Go on and have look! Sunday, March 1, 2009. Time really flies by so quickly!
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