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Mitsuyuki Onoguchi
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Tramadol is a centrally acting synthetic analgesic of the aminocyclohexanol group with opioid-like effects. Its mode of action is not completely understood but it appears to act by modifying transmission of pain impulses via inhibition of noradrenaline and serotonin re-uptake and also by weakly binding to mu-opioid receptors. 1) continued under treatment of pain;. 2) increased use of NSAIDS;. 3) increased use of potent opioids. Tramadol has demonstrated therapeutic usefulness in the treatment of moderate...
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