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According to the Alzheimer’s Association, 5.2 million Americans suffer from Alzheimer’s disease and the direct annual costs of the disease are more than $200 billion in the US.    EIP...

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According to the Alzheimer’s Association, 5.2 million Americans suffer from Alzheimer’s disease and the direct annual costs of the disease are more than $200 billion in the US.    EIP...

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Science - eip pharma

http://www.eippharma.com/science.html

Over the past 10-15 years, much of the focus in the pharmceutical industry has been on developing medicines that target amyloid plaques, the basis for which has been the earlier discovery that genetic defects that underlying familial Alzheimer’s disease encode proteins that either in the protein from which fragments (knowns as amyloid beta, or A. Targeting the protein p38 mitogen activated protein kinase (MAPK) alpha. Is a modulator of both. Has also been implicated in the tau phophorylation, as a mediat...

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Company - eip pharma

http://www.eippharma.com/company.html

EIP Pharma, LLC is a private company that has licensed-in and is developing VX-745, a phase 2 clinical-stage oral investigational drug that targets neuro-inflammation, dysfunction of microglia (the major immune-cell in the brain) and the effects of inflammation in the brain on neuronal and synaptic function. John Alam is an industry leader in translational medicine and has a track record of creating value to help build companies through clinical development success. Previously, from 1997 until 2008 he he...

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Pipeline - eip pharma

http://www.eippharma.com/pipeline.html

The investigational drug VX-745 specifically inhibits the intra-cellular enzyme p38 mitogen activated protein kinase alpha (MAPK alpha). VX-745 was discovered through a proprietary structure-based drug discovery platform at Vertex Pharmaceuticals, and more recently was licensed by EIP Pharma for development in central nervous system (CNS) disorders. Start-up activities are underway for two phase 2a clinical studies in patients with AD; both studies are anticipated to be underway early in 2015. Combin...

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EIP Pharma announces first patient dosing in phase 2 clinical studies of a novel brain-targeted

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Alpha;). Recent scientific developments indicate that aberrant. Alpha; activity within the neuron is a critical player in the molecular machinery that leads to the dysfunction of synapses that underlies memory deficits in Alzheimer's disease. EIP Pharma Publishes Positive Alzheimer's Phase 2a Clinical Data and Announces Phase 2b Study Start. Timmerman Report Article on New Directions in Alzheimer's Drug Development.

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