hastingslab.com hastingslab.com

hastingslab.com

Hastings LabChicago Medical SchoolRosalind Franklin University of Medicine and Science

Our lab investigates the molecular basis of human disease. A broad spectrum of diseases are caused by aberrant RNAs. We study how pre-mRNA. And expression of small non-coding regulatory microRNAs. Are altered in diseased cells. Usher syndrome. Are focuses of our research.

http://www.hastingslab.com/

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Hastings LabChicago Medical SchoolRosalind Franklin University of Medicine and Science | hastingslab.com Reviews
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Our lab investigates the molecular basis of human disease. A broad spectrum of diseases are caused by aberrant RNAs. We study how pre-mRNA. And expression of small non-coding regulatory microRNAs. Are altered in diseased cells. Usher syndrome. Are focuses of our research.
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1 splicing
2 batten disease
3 spinal muscular atrophy
4 and alzheimer’s disease
5 coupons
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Hastings LabChicago Medical SchoolRosalind Franklin University of Medicine and Science | hastingslab.com Reviews

https://hastingslab.com

Our lab investigates the molecular basis of human disease. A broad spectrum of diseases are caused by aberrant RNAs. We study how pre-mRNA. And expression of small non-coding regulatory microRNAs. Are altered in diseased cells. Usher syndrome. Are focuses of our research.

INTERNAL PAGES

hastingslab.com hastingslab.com
1

Alzheimer’s disease and splicing

http://www.hastingslab.com/hastingslab.com/Alzheimers_Project.html

Alzheimer’s disease and splicing.

2

Spinal Muscular ATrophy (SMA)

http://www.hastingslab.com/hastingslab.com/SMA_Project.html

Spinal Muscular ATrophy (SMA). Spinal muscular Atrophy affects approximately 1 in 6000 births. There is Currently no Cure for the disease. We are working to identify novel approaches and therapeutics for The treatment of SMA. Targeting SR proteins improves SMN expression in spinal muscular atrophy cells. Wee CD, Havens MA, Jodelka FM, Hastings ML. PLoS One. 2014 Dec 15;9(12):e115205. doi: 10.1371/journal.pone.0115205.

3

Development of treatments for deafness and blindness in Usher Syndrome

http://www.hastingslab.com/hastingslab.com/Usher_Syndrome.html

Development of treatments for deafness and blindness in Usher Syndrome. In the lab we are developing approaches to treat usher syndrome by manipulating pre-mrna splicing Using Antisense OligoNucleotides. Movie of Usher and non-Usher mice.

4

MicroRNAs in Polycystic kidney disease

http://www.hastingslab.com/hastingslab.com/PKD_Project.html

MicroRNAs in Polycystic kidney disease. A microrna in PKD1, the gene most frequently mutated in polycystic kidney disease, is processed by a non-canonical microRNa processing pathway. processing of the microrna and PKD1 mRNA production may be mutually exclusive. This potential competition between two RNA processing events could have implications for polycystic kidney disease.

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Our lab investigates the molecular basis of human disease. A broad spectrum of diseases are caused by aberrant RNAs. We study how pre-mRNA. And expression of small non-coding regulatory microRNAs. Are altered in diseased cells. Usher syndrome. Are focuses of our research.

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