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Targeting the Hedgehog pathway

Hedgehog pathway; signalling, role in mutation driven-cancer and as a therapeutic target. Basal cell carcinoma, types, risk factors and current treatments

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Targeting the Hedgehog pathway | hedgehogpathway.pt Reviews
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Hedgehog pathway; signalling, role in mutation driven-cancer and as a therapeutic target. Basal cell carcinoma, types, risk factors and current treatments
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1 hedgehog pathway
2 hedgehog and cancer
3 therapeutic target
4 basal cell carcinoma
5 advanced bcc
6 resources
7 hedgehog pathway inhibitors
8 hedgehog signalling
9 pathway in cancer
10 pathway
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hedgehog pathway,hedgehog and cancer,therapeutic target,basal cell carcinoma,advanced bcc,resources,hedgehog pathway inhibitors,hedgehog signalling,pathway in cancer,pathway,carcinoma,set resources,current treatments,treatment options,types of bcc,factors
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Targeting the Hedgehog pathway | hedgehogpathway.pt Reviews

https://hedgehogpathway.pt

Hedgehog pathway; signalling, role in mutation driven-cancer and as a therapeutic target. Basal cell carcinoma, types, risk factors and current treatments

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1

Types of BCC. Three subtypes, nodular, superficial and other

http://www.hedgehogpathway.pt/home/basal-cell-carcinoma/types-of-bcc.html

Types of basal cell carcinoma. There are several different clinical subtypes of basal cell carcinoma (BCC). Nodular BCC 2012 iSO-FORM, LLC. Approximately 60-80% of all BCCs. Are of the nodular variety. This type of BCC. Occurs more frequently on sun-exposed areas of the head and often presents as a papule or nodule. Superficial BCC 2012 iSO-FORM, LLC. Approximately 10-30% of all BCCs. Are the superficial variety. This type of BCC. Morpheaform BCC 2012 iSO-FORM, LLC. The remaining cases of BCC.

2

Resources. The Hedgehog pathway and cancer

http://www.hedgehogpathway.pt/home/resources.html

The slide sets and videos below illustrate the Hedgehog signalling pathway and its role in BCC. View this slide set to learn more about the Hedgehog signalling pathway. View this slide set to learn more about basal cell carcinoma. Roche Farmacêutica Química, Lda. Termos Legais. Este site utiliza cookies para optuimizar o seu funcionamento. Ao utilizar este site concorda com a colocação de cookies no seu dispositivo. O uso e acesso a este serviço encontra-se aos Termos de Utilização.

3

Risk factors of basal cell carcinoma

http://www.hedgehogpathway.pt/home/basal-cell-carcinoma/risk-factors.html

Basal cell carcinoma (BCC). Develops in the basal cell layer of the epidermis and, like most skin cancers, is caused by long-term or excessive exposure to the sun. Is most often found on the head and neck, and other sun exposed areas. While the majority of people with BCC. Are fair skinned or have skin that does not tan very easily, anyone can be at risk. Individuals who develop BCC. Are at a greater risk of developing further BCCs. Also presents more often in men than women. Other risk factors include:.

4

Advanced basal cell carcinoma. Suboptimal current treatment options

http://www.hedgehogpathway.pt/home/advanced-basal-cell-carcinoma.html

In some patients, if basal cell carcinoma (BCC). Is left untreated or has not responded to treatment. The cancer advances deeper into the skin, bones or other tissues and progresses to advanced BCC. Comprising locally advanced and metastatic BCC. Where surgery is inappropriate (e.g. inoperable or unresectable BCC. Can be disfiguring or debilitating and can lead to significant morbidity. Once metastasised, BCC. Is highly malignant and is associated with a poor prognosis; median survival is 8 to 14 months.

5

Hedgehog pathway; discovery and signalling

http://www.hedgehogpathway.pt/home/hedgehog-pathway.html

The Hedgehog (Hh) signalling. Plays an important role in the regulation of cell differentiation and organ formation during normal vertebrate embryonic development, ensuring that developing tissues attain their correct size, location, and cellular content. This pathway was first identified in 1980 by Christiane Nüsslein-Volhard and Eric Wieschaus during a screen for mutations that disrupt the fruit fly larval body plan. Therefore represents a potential therapeutic target. For new anticancer treatments.

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Targeting the Hedgehog pathway

Roche is researching Hedgehog pathway inhibition because abnormal activation of this pathway plays an important role in the pathogenesis of several types of cancer, notably basal cell carcinoma. BCC) also known as basal cell cancer or basal skin cancer. May therefore provide a new treatment option for patients with BCC and for patients with other forms of cancer. This website is a central resource for health care professionals with an interest in learning more about the Hedgehog pathway.

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