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药品说明书,多吉美说明书 更多,药品名称,通用名称 多吉美,拼音名称 duojimei,适应症 索拉非尼已被批准用于治疗晚期肾细胞癌 最常见的肾癌类型,用法用量 索拉非尼为一种红色、薄膜衣片剂,规格为每片200mg,若患者出现药物不良反应,索拉非尼给药剂量可降低到400mg,每天1次或隔天1次,注意事项 建议在索拉非尼治疗头6周内每周检测一次血压,活动性感染 包括真菌感染或病毒感染 患者在应用索拉非尼前宜先进行相关治疗,在服用索拉非尼期间,最好不要进行哺乳,索拉非尼在儿童患者中的安全性和有效性尚未得到验证
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多吉美 | hopepkchd.com Reviews

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多吉美

在索拉非尼治疗的患者中,3级和4级不良事件的数目分别占不良事件总数的31 和7 ,而安慰剂对照组患者则分别为22 和6。 由于索拉非尼可增加患者出血的风险,因此,同时合用华法林治疗的患者应定期进行相关检查 有活动性出血 如胃肠道出血 倾向的患者应慎用索拉非尼。 曾经有报道索拉非尼可能引起骨髓抑制 如中性粒细胞减少和血小板减少 ,所以,即往进行过骨髓抑制治疗 包括放疗和化疗 的患者在应用索拉非尼时应谨慎。 肝病患者、黄疸患者或肾病患者 CrCl 30ml min 应慎用索拉非尼。 药物相互作用 索拉非尼与阿霉素或依立替康合用时,后两者的药时曲线下面积 AUC 将分别增加21 和26 42 ,目前尚不清楚上述现象是否具有临床意义,但一般建议索拉非尼与上述两种药物合用时应注意密切观察。 临床前研究显示,索拉非尼能同时抑制多种存在于细胞内和细胞表面的激酶,包括RAF激酶、血管内皮生长因子受体 2 VEGFR 2 、血管内皮生长因子受体 3 VEGFR 3 、血小板衍生生长因子受体 β PDGFR β 、KIT和FLT 3。 版权所有 阿法替尼 电话 15561559685.

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