hsp90.ca
HSP90 Resource Guide | HSP90Heat Shock Protein 90 (HSP90) information database. A resource for all HSP90 structure, isoform, function, disease relevance, and inhibitor information.
http://www.hsp90.ca/
Heat Shock Protein 90 (HSP90) information database. A resource for all HSP90 structure, isoform, function, disease relevance, and inhibitor information.
http://www.hsp90.ca/
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HSP90 Resource Guide | HSP90 | hsp90.ca Reviews
https://hsp90.ca
Heat Shock Protein 90 (HSP90) information database. A resource for all HSP90 structure, isoform, function, disease relevance, and inhibitor information.
hsp90.ca
HSP90 Inhibitors | HSP90
http://hsp90.ca/inhibitors
Mechanisms & Interactions. IF detection of Hsp90 in cancerous mouse colon tissue, using Anti-Hsp90 (clone: H9010). Many oncogenic proteins essential for the transformation of cells are client proteins of Hsp90. Therefore, targeting Hsp90 with chemical inhibitors would degrade these oncogenic proteins and thus function as anti-cancer agents. Hsp90 inhibitors deplete Hsp90 client proteins in cancer cells without having any effect on their cellular counterparts in non-transformed cells. In most instances, n...
HSP90 Regulation | HSP90
http://hsp90.ca/regulation
Mechanisms & Interactions. IHC staining of inflammatory cells and epithelia mucosa in mouse colon tissues, using Anti-Hsp90 (clone: AC-16). When cells are subjected to environmental stress, they respond by enhancing expression of HSPs. The rapid induction of HSP in response to environmental stress is based on a variety of genetic and biochemical processes referred to as the heat shock response (HSR). Among them, HSF-1 is considered as being the key transcription factor of stress-inducible HSPs. Under non...
HSP90 Disease Relevance | HSP90
http://hsp90.ca/disease-relevance
Mechanisms & Interactions. IHC detection of Hsp90 in cancerous human colon tissue, using Anti-Hsp90 (clone: H9010). A growing wealth of evidence indicates the pivotal role of Hsp90 in tumourigenesis. Constitutively elevated levels of Hsp90 can be found in a broad spectrum of cancers suggesting a central role in survival and growth of malignant cells. 1 to the heterodimeric cell surface receptor Her-2/Her-3 thereby inducing HSF-1 stabilization which consequently enhanced cell survival and transformation.
HSP90 Protein Type | HSP90
http://hsp90.ca/protein-type
Mechanisms & Interactions. Hsp90 (total) visualized on a human keratinocyte line HaCat, using Anti-Hsp90 (total) (clone: 4F3.E8). The HSP90 family represents a group of well-conserved proteins with an average molecular mass of 90 kDa. There are two major cytosolic Hsp90 isoforms, the inducible Hsp90. 1 (HspC1) and the constitutive Hsp90. HspC3), commonly termed Hsp90. The HSP90 family members are encoded by a multigene family encompassing six genes and 11 pseudogenes in humans. The most studied genes are.
Discovery of HSP90 | HSP90
http://hsp90.ca/history
Mechanisms & Interactions. IHC staining of inflammatory cells in mouse colon tissue, using Anti-Hsp90 alpha (clone: Hyb-K41009). Heat shock protein 90 (Hsp90) was originally described amongst a defined set of heat shock proteins (HSPs) that are rapidly induced in fungal, plant and animal cells in response to acute thermal up-regulation. This HSP induction is referred to as the heat shock response (HSR) that is ubiquitous across the bacterial, archaeal and eukaryotic kingdoms. 83 kDa heat shock protein 2.
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HSP70 Inhibitors - Cancer Research Strategy & Review
http://hsp70.com/inhibitors
Mechanisms & Interactions. The inhibition of HSP70s has emerged as a promising anticancer strategy in preclinical and clinical trials. Targeting membrane-bound Hsp70-1 by the mouse monoclonal antibody cmHsp70.1 which specifically recognizes a C-terminal epitope of Hsp70-1 might be a promising approach as it selectively induces antibody-dependent toxicity of human tumor cells xenografted in mice. VER-155008 also inhibited proliferation of BT474 human breast cancer cells, induced Hsp90 client protein degra...
HSP60 Family Members | HSP60
http://hsp60.com/family-members
IHC of human skin fibroblasts (Left: control, Right: 24 hours after 7th passage of senescence), using Anti-Hsp60 (clone: LK1). The 60 kDa chaperonin family of proteins ( HSP60. Consists of molecular chaperones of approximately 60 kDa in size comprising stress inducible and constitutively expressed members. Which possesses one Hsp60 gene ( groEL. Several eubacteria contain up to seven HSP60/groEL. Archaea possess one to three homologous chaperonin-encoding genes except for Methanosarcina acetivorans.
Tables - HSP70
http://hsp70.com/tables
Mechanisms & Interactions. Table 1: Human and mouse orthologs of Hsp70-1 (HspA1A). Chr 6:31,789,963-31,798,031. Chr 17: 35.11 35.11 Mb. Table 2: HSP70s of various pro- and eukaryotic organisms. Hsp70-1, Hsp72, HspA1, Hsp70-1a, Hsp70i. Hsp70-1L, Hsp70-hom, Hsp70-1t, Hum70t. Hsp70-5, BiP, Grp78, Mif-2. Hsp70-8, Hsc70, Hsc71, Hsp71, Hsp73. Hsp70-9, Grp75, HspA9B, MOT, MOT2, PBP74, mot-2, mtHsp70. Hsp70-12A, FLJ13874, KIAA0417. Hsp70-12B, RP23-32L15.1, 2700081N06Rik. Ssa1p, HspSSA1, HspYG100.
HSP60 Isoforms | HSP60
http://hsp60.com/isoforms
IHC staining of human colon cancer, using Anti-Hsp60 (clone: LK2). Members of the 60 kDa chaperonin family are present in all eubacteria, Archaea and eukaryotic cell organelles such as mitochondria and chloroplasts. Eubacteria express up to seven Hsp60 homologs, referred to as GroEL. The human HSP60/HSPD family comprises ten gene products differing from each other by expression level, subcellular location and amino acid constitution ( Table 2. All eukaryotes have several HSP60/CCT. Genes leading to the e...
HSP60 Molecular Weight | HSP60
http://hsp60.com/molecular-weight
IHC staining of Listeria infected mice spleens 6 days after infection with L-monocytogenes, using Anti-Hsp60 (clone: LK2). The HSP60/CPN60 family represents a group of well-conserved proteins with molecular weights ranging from 57 69 kDa. Functional genes encoding HSP60 proteins map to human chromosomes 1, 2, 5, 6, 7, 17, and 21. Hsp60 (also known as HspD1, Cpn60 or mitochondrial Hsp60) is a molecular chaperonin that assist protein folding in mitochondria. Iterations of these repeats can also be found in...
HSP60 Regulation | HSP60
http://hsp60.com/regulation
IHC staining of Listeria infected mice spleens 6 days after infection with L-monocytogenes, using Anti-Hsp60 (clone: LK2). When cells are subjected to environmental stress, they respond by enhancing expression of HSPs. A total of five HSP families are known to be induced by stress including the HSP60 family of chaperones. The rapid induction of HSP in response to environmental stress is based on a variety of genetic and biochemical processes referred to as the heat shock response (HSR). HSF-1 activation ...
HSP60 Disease Relevance | HSP60
http://hsp60.com/disease-relevance
IHC of human skin fibroblasts (Left: control, Right: 24 hours after 7th passage of senescence), using Anti-Hsp60 (clone: LK1). Hsp60 chaperonopathies are inherited or acquired pathological conditions in which Hsp60 plays an etiologic-pathogenic role. Considering mechanisms and levels of activity and concentration, chaperonopathies can be subgrouped into by defect, excess or mistake. For instance, genetic Hsp60 chaperonopathies by defect comprise hereditary spastic paraplegia SPG13. And Cappello et al.
Discovery of HSP60 | HSP60
http://hsp60.com/history
IHC staining of human colon cancer, 1:100,000, using Anti-Hsp60 (clone: LK1). The existence of heat shock proteins (HSPs) was suggested first in the early 1960s by the Italian geneticist Ferruccio Ritossa on the fruitfly Drosophila melanogaster. Where dramatic changes in the puffering pattern of the polytene chromosomes in Drosophila’s. Salivary glands could be observed upon exposure to heat shock. After exposure to heat shock in the early 1970s. GroEL was originally identified in E. coli. As a large oli...
HSP40 Disease Relevance | HSP40
http://hsp40.com/disease-relevance
ICC staining of Hsp47 in heat shocked HeLa cells using Anti-Hsp47 (clone: 1C4-1A6). And a FITC secondary (green: cytoplasm; blue: DAPI nuclear stain). Aberrant protein aggregation is the key feature of the pathology of most neurodegenerative diseases, including Alzheimer’s disease (AD), Parkinson’s disease (PD), Huntington’s disease (HD) and amyotrophic lateral sclerosis (ALS). Exome-sequencing analyses have identified DnaJC13/Rme-8 to bear disease-causing variants for both, PD and essential tremor.
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Blog de hsp7100hsp - MOI & ma L!F3......... :d :d - Skyrock.com
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hsp90-inhibitors|hsp90-inhibitors.com
New and Potent HSP inhibitors are available. Including HSP90/70 inhibitors drugs in clinical trials. Skip to primary content. Skip to secondary content. 63; Fig 3) Interestingly, the interaction Owner Interval sign. March 29, 2018. 63; Fig. 3). Interestingly, the interaction Owner Interval significant for the right. Hemisphere stimulation PD0332991 mw. Or not). To control for right hemispheric. However, it has been recently reported that PTEN. March 29, 2018. Mutations are more frequent in low-grade endo...
HSP90 Resource Guide | HSP90
Mechanisms & Interactions. HSP90 proteins define a widespread family of molecular chaperones found in bacteria and all eukaryotes playing a fundamental role in protein homoeostasis and viability. HSP90s primarily exist as homodimers whose activity is regulated by ATP. HSP90 chaperones can be found not only in the cytosol, ER, chloroplasts, mitochondria, and the nucleus. But also in the extracellular milieu where they act as potent stimulators of immune responses.
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Home - Hsp90
Next Hsp90 meeting will take place in Leysin, Switzerland. October 17 to 21, 2018. Photo from http:/ www.leysin.ch/en/. For more details: click. At one of the first Hsp90 meetings, in Gwatt in 2004, the idea came up that it would be useful for the community to have a dedicated and not-for-profit web site to serve as a focal point. The domain name was therefore registered by Didier Picard who is a basic research scientist working at an academic institution.
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