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humanized-mice.org

Humanized Mouse Program - Home

The Marasco Laboratory at Dana-Farber Cancer Institute constructs and validates various Human-Mouse chimeric models. These ‘humanized’ mouse models are excellent platforms to perform translational and preclinical research.

http://www.humanized-mice.org/

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CONTACTS AT HUMANIZED-MICE.ORG

Dana-Farber Cancer Institute

Dave Rothfarb

450 Br●●●●●●ne Ave

Bo●●on , MA, 02215

US

1.61●●●●8328
he●●●●●●●●●●●●●●●●●●@dfci.harvard.edu

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Dana-Farber Cancer Institute

Dave Rothfarb

450 Br●●●●●●ne Ave

Bo●●on , MA, 02215

US

1.61●●●●8328
he●●●●●●●●●●●●●●●●●●@dfci.harvard.edu

View this contact

Dana-Farber Cancer Institute

Dave Rothfarb

450 Br●●●●●●ne Ave

Bo●●on , MA, 02215

US

1.61●●●●8328
he●●●●●●●●●●●●●●●●●●@dfci.harvard.edu

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Humanized Mouse Program - Home | humanized-mice.org Reviews
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The Marasco Laboratory at Dana-Farber Cancer Institute constructs and validates various Human-Mouse chimeric models. These ‘humanized’ mouse models are excellent platforms to perform translational and preclinical research.
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1 cancer
2 hepatitis
3 dana farber
4 drug tests
5 stem cells
6 what is stem cell
7 HIV /AIDS
8 hematology
9 cancer research
10 infectious diseases
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news,staff,mission,mouse models,policies,cost,location,relevant literature,opportunities,downloadable brochure,news and events,and oncoimmunology,new publication,related websites,marasco lab,in vivo,studies,evaluation of vaccines,human infectious diseases
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Humanized Mouse Program - Home | humanized-mice.org Reviews

https://humanized-mice.org

The Marasco Laboratory at Dana-Farber Cancer Institute constructs and validates various Human-Mouse chimeric models. These ‘humanized’ mouse models are excellent platforms to perform translational and preclinical research.

INTERNAL PAGES

humanized-mice.org humanized-mice.org
1

Humanized Mouse Program - Cancer models/tumor immunotherapy

http://www.humanized-mice.org/index.php/relevant-literature/cancer-models

Human immune system development. GANT-61 inhibits pancreatic cancer stem cell growth in vitro and in NOD/SCID/IL2R? Null mice xenograft. Fu J, Rodova M, Roy SK, Sharma J, Singh KP, Srivastava RK, Shankar S. Cancer Lett. 2012 Nov 28. doi:pii: S0304-3835(12)00665-9. 10.1016/j.canlet.2012.11.018. PMID: 23200667. PMID: 21935406, PMCID: PMC3174163. Antitumor activity from antigen-specific CD8 T cells generated in vivo from genetically engineered human hematopoietic stem cells. Vatakis DN, Koya RC, Nixon C...

2

Humanized Mouse Program - Mission

http://www.humanized-mice.org/index.php/mission

Our goal is to provide humanized mouse models to the research community, to collaborate on research studies of common interest, and to advance the general use of these models for a broad range of translational and preclinical studies. We disseminate knowledge through education and high-quality research publications. We have over 4 years of experience in constructing several different types of humanized mouse models, some of which are described on our website ( mouse models.

3

Humanized Mouse Program - Hematopoiesis

http://www.humanized-mice.org/index.php/relevant-literature/hematopoiesis

Human immune system development. Comparison of hematopoietic stem cells derived from fresh and cryopreserved whole cord blood in the generation of humanized mice. Scholbach J, Schulz A, Westphal F, Egger D, Wege AK, Patties I, Köberle M, Sack U, Lange F. PLoS One. 2012;7(10):e46772. doi: 10.1371/journal.pone.0046772. Epub 2012 Oct 11. PMID: 23071634. Antibody Repertoires in Humanized NOD-scid-IL2R? Human thrombopoietin knockin mice efficiently support human hematopoiesis in vivo. Rongvaux A, Willinge...

4

Humanized Mouse Program - Regenerative Medicine/Tissue Engineering

http://www.humanized-mice.org/index.php/relevant-literature/regenerative-medicinetissue-engineering

Human immune system development. Skin bioengineering: preclinical and clinical applications. Martínez-Santamaría L, Guerrero-Aspizua S, Del Río M. Actas Dermosifiliogr. 2012 Jan;103(1):5-11. Epub 2012 Mar 29. Clones of ectopic stem cells in the regeneration of muscle defects in vivo. Yang R, Chen M, Lee CH, Yoon R, Lal S, Mao JJ. PLoS One. 2010 Oct 20;5(10):e13547. PMID: 20975999. Click on logos for links to our other sites. Site developed by DF/HCC Health Communication Core.

5

Humanized Mouse Program - Autoimmunity and tolerance

http://www.humanized-mice.org/index.php/relevant-literature/autoimmunity-and-tolerance

Human immune system development. Graft versus host disease in the bone marrow, liver and thymus humanized mouse model. Greenblatt MB, Vbranac V, Tivey T, Tsang K, Tager AM, Aliprantis AO. PLoS One. 2012;7(9):e44664. doi: 10.1371/journal.pone.0044664. Epub 2012 Sep 5. PMID: 22957096. Xenogeneic graft-versus-host-disease in NOD-scid IL-2R? Teplizumab induces human gut-tropic regulatory cells in humanized mice and patients. Humanized mice for the study of type 1 and type 2 diabetes. Greiner DL, Brehm MA...

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Humanized Mouse Program - Home

2015 - New Publications in Molecular Cancer. Oct 2012 - Opening of the Humanized Neonatal Mouse Center (HNMC). Human antibody gene repertoire analysis in hNSG mice. Affiliated Faculty of Harvard Stem Cell Institute. Feb 2012 - Humanized Mouse Program open to research community. Humanized Neonatal Mouse Center (HNMC). National Foundation for Cancer Research - Center for Therapeutic Antibody Engineering. Hu-mouse splenic follicle with human T (green) and B (red) cells. Provide humanized mouse models for.

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