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iGNM - Online service for Gaussian Network Model

Computational and Systems Biology. What is the GNM DB? Which questions can be answered? Several studies in the last decade have drawn attention to the significance of intrinsic dynamics as a major determinant of the mechanism of action of proteins and their complexes (1-5). Intrinsic dynamics refers to conformational changes intrinsically favored by 3D structure, which often underlie the adaptation of biomolecules to functional interactions (6). Or which ones provide adequate flexibility. 2 Dobbins,S....

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iGNM - Online service for Gaussian Network Model | ignm.ccbb.pitt.edu Reviews

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Computational and Systems Biology. What is the GNM DB? Which questions can be answered? Several studies in the last decade have drawn attention to the significance of intrinsic dynamics as a major determinant of the mechanism of action of proteins and their complexes (1-5). Intrinsic dynamics refers to conformational changes intrinsically favored by 3D structure, which often underlie the adaptation of biomolecules to functional interactions (6). Or which ones provide adequate flexibility. 2 Dobbins,S&#46...

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8 note

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iGNM - Online service for Gaussian Network Model | ignm.ccbb.pitt.edu Reviews

https://ignm.ccbb.pitt.edu

Computational and Systems Biology. What is the GNM DB? Which questions can be answered? Several studies in the last decade have drawn attention to the significance of intrinsic dynamics as a major determinant of the mechanism of action of proteins and their complexes (1-5). Intrinsic dynamics refers to conformational changes intrinsically favored by 3D structure, which often underlie the adaptation of biomolecules to functional interactions (6). Or which ones provide adequate flexibility. 2 Dobbins,S&#46...

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iGNM - Online service for Gaussian Network Model

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Computational and Systems Biology. What is the GNM DB? Which questions can be answered? Several studies in the last decade have drawn attention to the significance of intrinsic dynamics as a major determinant of the mechanism of action of proteins and their complexes (1-5). Intrinsic dynamics refers to conformational changes intrinsically favored by 3D structure, which often underlie the adaptation of biomolecules to functional interactions (6). Or which ones provide adequate flexibility. 2 Bahar,I.,...

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iGNM 2.0 - Gaussian Network Model database

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Computational and Systems Biology. 1 Li,H., Chang,YY, Yang,LW and Bahar,I. (2016) iGNM 2.0: The Gaussian Network Model Database for Biomolecular Structural Dynamics. 2 Flory,P.J. (1976) Statistical thermodynamics of random networks. Proc R. Soc. Lond. A. 3 Bahar,I., Atilgan,A.R. and Erman,B. (1997) Direct evaluation of thermal fluctuations in proteins using a single-parameter harmonic potential. Phys Rev. Lett. Curr Opin. Struct. Biol. Chapman and Hall/CRC: Boca Raton, FL, pp. 41-64. WIREs Comput Mol Sci.

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iGNM - Online service for Gaussian Network Model

Computational and Systems Biology. What is the GNM DB? Which questions can be answered? Several studies in the last decade have drawn attention to the significance of intrinsic dynamics as a major determinant of the mechanism of action of proteins and their complexes (1-5). Intrinsic dynamics refers to conformational changes intrinsically favored by 3D structure, which often underlie the adaptation of biomolecules to functional interactions (6). Or which ones provide adequate flexibility. 2 Dobbins,S&#46...

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