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Go to The Journal of Clinical Investigation. Latest issue: December 22, 2016. ABL promotes lung cancer metastasis. ATG16L1 governs placental infection risk and preterm birth in mice and women. Bin Cao, Colin Macones, Indira U. Mysorekar. Bin Cao, Colin Macones, Indira U. Mysorekar. Autophagy is an important component of placental host defenses and susceptibility to preterm birth in mice and humans. ATG16L1 governs placental infection risk and preterm birth in mice and women. Regeneration of hepatic sinus...

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Go to The Journal of Clinical Investigation. Latest issue: December 22, 2016. ABL promotes lung cancer metastasis. ATG16L1 governs placental infection risk and preterm birth in mice and women. Bin Cao, Colin Macones, Indira U. Mysorekar. Bin Cao, Colin Macones, Indira U. Mysorekar. Autophagy is an important component of placental host defenses and susceptibility to preterm birth in mice and humans. ATG16L1 governs placental infection risk and preterm birth in mice and women. Regeneration of hepatic sinus...

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JCI Insight -Welcome | insight.jci.org Reviews

https://insight.jci.org

Go to The Journal of Clinical Investigation. Latest issue: December 22, 2016. ABL promotes lung cancer metastasis. ATG16L1 governs placental infection risk and preterm birth in mice and women. Bin Cao, Colin Macones, Indira U. Mysorekar. Bin Cao, Colin Macones, Indira U. Mysorekar. Autophagy is an important component of placental host defenses and susceptibility to preterm birth in mice and humans. ATG16L1 governs placental infection risk and preterm birth in mice and women. Regeneration of hepatic sinus...

INTERNAL PAGES

insight.jci.org

1

JCI Insight -ATG16L1 governs placental infection risk and preterm birth in mice and women

http://insight.jci.org/articles/view/86654/figure/1

Go to The Journal of Clinical Investigation. ATG16L1 governs placental infection risk and preterm birth in mice and women. Bin Cao, Colin Macones, Indira U. Mysorekar. Bin Cao, Colin Macones, Indira U. Mysorekar. Published December 22, 2016. Citation Information: JCI Insight. E86654. doi: 10.1172/jci.insight.86654. ATG16L1 governs placental infection risk and preterm birth in mice and women. Bin Cao, Colin Macones, Indira U. Mysorekar. Options: View larger image. Or click on image). 10), late preterm (.

2

JCI Insight -Welcome

http://insight.jci.org/tags/31

Go to The Journal of Clinical Investigation. Repair after nephron ablation reveals limitations of neonatal neonephrogenesis. Florian Tögel . Mor Grinstein, Joseph V. Bonventre. Florian Tögel . Mor Grinstein, Joseph V. Bonventre. Published January 26, 2017. Citation Information: JCI Insight. E88848. doi: 10.1172/jci.insight.88848. Repair after nephron ablation reveals limitations of neonatal neonephrogenesis. Chorioretinal thinning in chronic kidney disease links to inflammation and endothelial dysfunction.

3

JCI Insight -About the Editors

http://insight.jci.org/kiosks/editorial-board

Go to The Journal of Clinical Investigation. Howard A. Rockman, MD,. Sarah Jackson, PhD,. Jillian Hurst, PhD,. Corinne Williams, PhD,. Is a Science Editor for the JCI and JCI Insight. She received her PhD in molecular, cellular, and developmental biology from the University of California, Santa Barbara. As a graduate student in the laboratory of Peggy Cotter, she focused her research on gene regulation and virulence in bacterial respiratory pathogens of the genus. Sign up for email alerts.

4

JCI Insight -HDL activation of endothelial sphingosine-1-phosphate receptor-1 (S1P1) promotes regeneration and suppresses fibrosis in the liver

http://insight.jci.org/articles/view/87058/figure/1

Go to The Journal of Clinical Investigation. HDL activation of endothelial sphingosine-1-phosphate receptor-1 (S1P. Promotes regeneration and suppresses fibrosis in the liver. Bi-Sen Ding . Shahin Rafii, Timothy Hla. Bi-Sen Ding . Shahin Rafii, Timothy Hla. Published December 22, 2016. Citation Information: JCI Insight. E87058. doi: 10.1172/jci.insight.87058. HDL activation of endothelial sphingosine-1-phosphate receptor-1 (S1P. Promotes regeneration and suppresses fibrosis in the liver. Enhanced regener...

5

JCI Insight -Heterogeneous perivascular cell coverage affects breast cancer metastasis and response to chemotherapy

http://insight.jci.org/articles/view/90733/figure/1

Go to The Journal of Clinical Investigation. Heterogeneous perivascular cell coverage affects breast cancer metastasis and response to chemotherapy. Jiha Kim . Funda Meric-Bernstam, Valerie S. LeBleu. Jiha Kim . Funda Meric-Bernstam, Valerie S. LeBleu. Published December 22, 2016. Citation Information: JCI Insight. E90733. doi: 10.1172/jci.insight.90733. Heterogeneous perivascular cell coverage affects breast cancer metastasis and response to chemotherapy. Options: View larger image. Or click on image).

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JCI -Monogenic hypercholesterolemia: new insights in pathogenesis and treatment

http://www.jci.org/articles/view/18925/pdf

Go to JCI Insight. Conversations with Giants in Medicine. Hypoxia and Inflammation (Upcoming). Extracellular Vesicles (Apr 2016). Cancer Immunotherapy (Sep 2015). Enteric Nervous System (Mar 2015). View all review series. The Journal of Clinical Investigation. Conversations with Giants in Medicine. Monogenic hypercholesterolemia: new insights in pathogenesis and treatment. Daniel J. Rader, Jonathan Cohen, Helen H. Hobbs. Daniel J. Rader, Jonathan Cohen, Helen H. Hobbs. Published June 15, 2003.

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JCI -Fatty acid–induced gut-brain signaling attenuates neural and behavioral effects of sad emotion in humans

http://www.jci.org/articles/view/46380

Go to JCI Insight. Conversations with Giants in Medicine. Hypoxia and Inflammation (Upcoming). Extracellular Vesicles (Apr 2016). Cancer Immunotherapy (Sep 2015). Enteric Nervous System (Mar 2015). View all review series. The Journal of Clinical Investigation. Conversations with Giants in Medicine. Citations to this article. Fatty acid induced gut-brain signaling attenuates neural and behavioral effects of sad emotion in humans. Lukas Van Oudenhove,. Department of Gastrointestinal Sciences and. Address c...

jci.org

JCI -Resistance to Lyme disease in decorin-deficient mice

http://www.jci.org/articles/view/11692

Go to JCI Insight. Conversations with Giants in Medicine. Hypoxia and Inflammation (Upcoming). Extracellular Vesicles (Apr 2016). Cancer Immunotherapy (Sep 2015). Enteric Nervous System (Mar 2015). View all review series. The Journal of Clinical Investigation. Conversations with Giants in Medicine. Citations to this article. Resistance to Lyme disease in decorin-deficient mice. Eric L. Brown,. R Mark Wooten,. Barbara J.B. Johnson,. Renato V. Iozzo,. Marc C. Dolan,. Betty P. Guo,. Janis J. Weis,. The Cent...

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JCI -Vascular rarefaction mediates whitening of brown fat in obesity

http://www.jci.org/articles/view/71643

Go to JCI Insight. Conversations with Giants in Medicine. Hypoxia and Inflammation (Upcoming). Extracellular Vesicles (Apr 2016). Cancer Immunotherapy (Sep 2015). Enteric Nervous System (Mar 2015). View all review series. The Journal of Clinical Investigation. Conversations with Giants in Medicine. Citations to this article. Vascular rarefaction mediates whitening of brown fat in obesity. Kyriakos N. Papanicolaou,. Molecular Cardiology and Whitaker Cardiovascular Institute, and. Department of Medicine Re...

jci.org

JCI -Cold acclimation recruits human brown fat and increases nonshivering thermogenesis

http://www.jci.org/articles/view/68993

Go to JCI Insight. Conversations with Giants in Medicine. Hypoxia and Inflammation (Upcoming). Extracellular Vesicles (Apr 2016). Cancer Immunotherapy (Sep 2015). Enteric Nervous System (Mar 2015). View all review series. The Journal of Clinical Investigation. Conversations with Giants in Medicine. Citations to this article. Cold acclimation recruits human brown fat and increases nonshivering thermogenesis. Anouk A.J.J. van der Lans,. Guy HE.J. Vijgen,. Mariëlle G.W. Visser,. Maarten J. Vosselman,. Depar...

immunology.medicine.pitt.edu

Shlomchik Lab paper selected as cover article for February 2017 JCI Insight | Department of Immunology | University of Pittsburgh

http://immunology.medicine.pitt.edu/news-story/shlomchik-lab-paper-selected-cover-article-february-2017-jci-insight

Shlomchik Lab paper selected as cover article for February 2017 JCI Insight. A paper published by the laboratory of Dr. Mark Shlomchik, UPMC Endowed Professor and Chair of Immunology, has been selected as the cover article for February 2017 JCI Insight. The paper, entitled, "Autoreactive helper T cells alleviate the need for intrinsic TLR signaling in autoreactive B cell activation," can be found found by clicking here. E1040 Thomas E. Starzl Biomedical Science Tower.

jci.org

JCI -The organization and consequences of eicosanoid signaling

http://www.jci.org/cgi/content/full/111/8/1107

Go to JCI Insight. Conversations with Giants in Medicine. Hypoxia and Inflammation (Upcoming). Extracellular Vesicles (Apr 2016). Cancer Immunotherapy (Sep 2015). Enteric Nervous System (Mar 2015). View all review series. The Journal of Clinical Investigation. Conversations with Giants in Medicine. Citations to this article. Organization of leukotriene and prostaglandin synthesis. The role of leukotrienes C4 and D4 in disease. Cellular and molecular biology of LT biosynthesis. Signaling by LTs and PGs.

jci.org

JCI -Notch1 is an effector of Akt and hypoxia in melanoma development

http://www.jci.org/articles/view/36157

Go to JCI Insight. Conversations with Giants in Medicine. Hypoxia and Inflammation (Upcoming). Extracellular Vesicles (Apr 2016). Cancer Immunotherapy (Sep 2015). Enteric Nervous System (Mar 2015). View all review series. The Journal of Clinical Investigation. Conversations with Giants in Medicine. Citations to this article. Notch1 is an effector of Akt and hypoxia in melanoma development. James A. Warneke,. Brian J. Nickoloff,. Amato J. Giaccia,. Find articles by Bedogni, B. in: JCI. Find articles by Wa...

jci.org

JCI -SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver

http://www.jci.org/articles/view/15593

Go to JCI Insight. Conversations with Giants in Medicine. Hypoxia and Inflammation (Upcoming). Extracellular Vesicles (Apr 2016). Cancer Immunotherapy (Sep 2015). Enteric Nervous System (Mar 2015). View all review series. The Journal of Clinical Investigation. Conversations with Giants in Medicine. Citations to this article. SREBPs: activation through proteolytic processing. SREBPs: two genes, three proteins. Knockout and transgenic mice. Function of individual SREBP isoforms in vivo. Jay D Horton,.

jci.org

JCI -Volume 126, Issue 8

http://www.jci.org/current

Go to JCI Insight. Conversations with Giants in Medicine. Hypoxia and Inflammation (Upcoming). Extracellular Vesicles (Apr 2016). Cancer Immunotherapy (Sep 2015). Enteric Nervous System (Mar 2015). View all review series. The Journal of Clinical Investigation. Conversations with Giants in Medicine. Issue published August 1, 2016. Volume 126, Issue 8, Pages 2775-3158. CAR T cells with intrinsic checkpoint blockade. The bright side of dark matter: lncRNAs in cancer. Published August 1, 2016. Maged M. C...

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JCI Insight -Welcome

Go to The Journal of Clinical Investigation. Latest issue: December 22, 2016. ABL promotes lung cancer metastasis. ATG16L1 governs placental infection risk and preterm birth in mice and women. Bin Cao, Colin Macones, Indira U. Mysorekar. Bin Cao, Colin Macones, Indira U. Mysorekar. Autophagy is an important component of placental host defenses and susceptibility to preterm birth in mice and humans. ATG16L1 governs placental infection risk and preterm birth in mice and women. Regeneration of hepatic sinus...

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Kellogg School of Management at Northwestern University. The faculty of the Kellogg School of Management. Bring their latest research and expertise to you in an accessible, engaging format. More →. Juries Treat Prestigious Companies Differently in Employment Discrimination Suits. But beware, a good reputation is a double-edged sword. Does Lowering the Corporate Tax Rate Spur Economic Growth? Results of a new study have implications for the recent U.S. tax overhaul. Trying to Be Persuasive? CSR is in vogu...