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Genetics » Conformational Flux
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Venter Institute synthesizes a bacterial genome. Continuing the banner day, Daniel G. Gibson and colleagues have published a rather subdued article in Science. In this truly impressive experiment, a group from the J. Craig Venter Institute. Synthesized and assembled an entire 583 kilobase-pair genome of Mycoplasma genitalium. Besides being a fairly cool piece of work all on its own, this outcome has profound implications for the future of bacterial research and the development of custom organisms. Recomb...
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Discussion » Conformational Flux
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Proving conformational selection is hard. Allosteric regulation of proteins is often examined using two different models. The widely-known “induced-fit” (IF) model proposes that effectors form a loose complex with inactive proteins and cause them to shift into a new, active conformation. In the competing “conformational selection” model, effectors bind to and stabilize proteins that are already in an active conformation. An upcoming paper in the. Journal of the American Chemical Society. R state) and TbL...
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Drug Discovery » Conformational Flux
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A step towards incorporating dynamics data into drug design. My field-cycling article (previous post) is part of a dynamics-focused topical issue of JBNMR. In my next few science posts I’ll describe some of the other contributions. The dynamics of the protein target, not the small molecules it binds. If dynamics studies are to make the maximum possible contribution to pharmaceutical sciences, the motions of the ligand must be characterized. In their article in Journal of Biomolecular NMR. Pro, only the r...
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Enzymology » Conformational Flux
http://conflux.mwclarkson.com/category/biochemistry/enzymes
Proving conformational selection is hard. Allosteric regulation of proteins is often examined using two different models. The widely-known “induced-fit” (IF) model proposes that effectors form a loose complex with inactive proteins and cause them to shift into a new, active conformation. In the competing “conformational selection” model, effectors bind to and stabilize proteins that are already in an active conformation. An upcoming paper in the. Journal of the American Chemical Society. R state) and TbL...
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NMR » Conformational Flux
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A Multidrug Resistance Protein Caught in the Act. Bacteria have an additional mechanism to attack our medicines, however, in the form of multidrug resistance genes. These proteins. Can recognize an array of toxic molecules, often using general properties, and expel them from the cell. As such, every single one of these genes can take out multiple medicines. One of these multidrug resistance exporters is EmrE, a member of the small multidrug resistance (SMR) family of genes. EmrE is a proton-drug. Induce ...
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Comment Policy » Conformational Flux
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1) Be respectful of others. Do not use language that is racist, sexist, homophobic, or otherwise exclusionary or offensive. Do not SHOUT. Do not break the scroll. Do not hotlink images. Do be polite. 2) Comments should be substantive and germane. Derailing is absolutely forbidden, as is denialism. Derailing for Dummies. Is a helpful guide to what not to do. 4) This blog is intended for a broad audience. Therefore, do not swear. On Alternate structures and catalysis in cyclophilin. Stan's NMR Blog.
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Medicine » Conformational Flux
http://conflux.mwclarkson.com/category/medicine
Can videogames help treat amblyopia? Given that videogames are often demonized by research (and “research”) blaming them for everything from rudeness to the epidemic of youth violence. Gamers often take a great deal of cheer from research attaching positive outcomes to videogame play. One such article that recently attracted some attention was work suggesting that playing videogames could correct amblyopia. So let’s open it up and take a look. Medal of Honor: Pacific Assault. 8216; well-known liberal bias.
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Physical Chemistry » Conformational Flux
http://conflux.mwclarkson.com/category/chemistry/physical-chemistry
Can oil and water mix? Suggests that sufficiently long alkanes might undergo a similar transition, even though they don’t have any chemical groups that like to interact with water. Researchers from Purdue University performed a variety of simulations of linear alkanes. Configuration. As chain length increases, however, the numerous additional degrees of freedom allow a chain to adopt a more compact conformation that decreases the penalty incurred by interacting with water. Not Exactly Rocket Science.
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Expert » Conformational Flux
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Why HisH doesn’t fire until it sees the whites of PRFAR’s eyes. The enzyme imidazole glycerophosphate synthase (IGPS) can be a bit of a lump. If you bind just one substrate it doesn’t do anything, even though its two active sites are separated by more than 30 Å. Only if the second substrate. Binds does catalysis actually go at anything like a respectable rate. In a recent paper in. Researchers from Yale report evidence that this change of pace results from a change in dynamics. Unfortunately, these therm...
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