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Aptevo Therapeutics is a biotechnology company focused on developing novel oncology and hematology therapeutics to meaningfully improve patients' lives

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Investor Home : Investors : Aptevo | ir.aptevotherapeutics.com Reviews

https://ir.aptevotherapeutics.com

Aptevo Therapeutics is a biotechnology company focused on developing novel oncology and hematology therapeutics to meaningfully improve patients' lives

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aptevotherapeutics.com aptevotherapeutics.com

MOR209/ES414 (anti-PSMA x anti-CD3) : Aptevo

http://aptevotherapeutics.com/mor209es414-anti-psma-x-anti-cd3

MOR209/ES414 (anti-PSMA x anti-CD3). MOR209/ES414 is a humanized, bispecific ADAPTIR molecule that binds to prostate-specific membrane antigen (PSMA) and CD3. PSMA expression is upregulated in prostate cancer and is highest in advanced, metastatic castration-resistant prostate cancer (mCRPC). The MOR209/ES414 mechanism of action is to redirect T cells to kill PSMA-expressing tumor cells. MOR209/ES414 induces potent redirected T-cell cytotoxicity of tumors in. In 2015 Aptevo Therapeutics initiated a Phase...

aptevotherapeutics.com aptevotherapeutics.com

OTLERTUZUMAB (anti-CD37) : Aptevo

http://aptevotherapeutics.com/otlertuzumab-anti-cd37

Otlertuzumab (originally known as TRU-016) is a humanized monospecific ADAPTIR™ molecule that targets CD37. CD37 is a cell surface protein expressed on normal and transformed B cells that has been implicated in diverse cellular processes including cell adhesion, proliferation, differentiation, motility, and tumor invasion. Otlertuzumab induces cell death of primary CLL cells and B-cell tumor lines in vitro. Chronic lymphocytic leukemia (CLL). The purpose of this study is to evaluate the safety and effica...

aptevotherapeutics.com aptevotherapeutics.com

Careers : Aptevo

http://aptevotherapeutics.com/careers

The passion to make a difference. Looking for a rewarding career at a company standing at the forefront of today’s biotech industry? Look no further Aptevo Therapeutics is attracting some of the best minds in the field. Our rich heritage of leadership and innovation combined with forward thinking makes Aptevo Therapeutics unique among its competitors.

aptevotherapeutics.com aptevotherapeutics.com

Management Team : Aptevo

http://aptevotherapeutics.com/management-team

Marvin L. White, President and Chief Executive Officer. Jeff Lamothe, SVP and Chief Financial Officer. Scott C. Stromatt, M.D., Chief Medical Officer & SVP, Clinical Development & Medical Affairs. Randy J. Maddux, SVP Operations. Jane Gross, Ph.D., Senior Vice President and Chief Scientific Officer. Mike Adelman, VP, Commercial Operations. Shawnte Mitchell, VP, Human Resources, General Counsel and Corporate Secretary. Marvin L. White, President and Chief Executive Officer.

aptevotherapeutics.com aptevotherapeutics.com

APVO425 (anti-ROR1 x anti-CD3) : Aptevo

http://aptevotherapeutics.com/apvo425-anti-ror1-x-anti-cd3

APVO425 (anti-ROR1 x anti-CD3). APVO425 is a humanized, bispecific ADAPTIR molecule targeting the receptor tyrosine kinase-like orphan receptor 1 (ROR1) and CD3. ROR1 is a tumor-specific antigen that is upregulated in many B-cell malignancies, including chronic lymphocytic leukemia and mantle cell lymphoma, and solid malignancies, including prostate cancer, ovarian cancer, renal cell carcinoma, non-small cell lung cancer, triple negative breast cancer (TNBC), and pancreatic cancer.

aptevotherapeutics.com aptevotherapeutics.com

Commercial Products : Aptevo

http://aptevotherapeutics.com/commercial-products

Novel treatments for people with bleeding disorders and cancer. At Aptevo Therapeutics, we take pride in our products that treat rare bleeding disorders and other conditions. This feeling comes not only from creating and offering various treatments. It grows from a deep understanding of patient communities. Hearing the stories that drive our connection to what people want and need from therapy and beyond. To us, that’s at the heart of innovation. Our established portfolio of market products.

aptevotherapeutics.com aptevotherapeutics.com

Pipeline : Aptevo

http://aptevotherapeutics.com/pipeline

Innovation is at the heart of our product portfolio. Pipeline is available for partnering opportunities (other than MOR209/ES414). Otlertuzumab, originally known as TRU-016 (anti-CD37). MOR209/ES414 (anti-PSMA x anti-CD3). APVO425 (anti-ROR1 x anti-CD3). Additional RTCC assets (targets not disclosed). Otlertuzumab, originally known as TRU-016 (anti-CD37). MOR209/ES414 (anti-PSMA x anti-CD3). APVO425 (anti-ROR1 x anti-CD3). Additional RTCC assets (targets not disclosed). ES210 (anti-CD86 x monoIL-10).

aptevotherapeutics.com aptevotherapeutics.com

Board of Directors : Aptevo

http://aptevotherapeutics.com/board-of-directors

Marvin L. White. Daniel J. Abdun-Nabi. Grady Grant, III. Zsolt Harsanyi, Ph.D. John E. Niederhuber, M.D. Marvin L. White. Daniel J. Abdun-Nabi. Grady Grant, III. Mr Grant is the Vice President of Medical Sales for Mead Johnson Nutrition, a public company focused on pediatric nutrition. He has held this position since December 2011, preceded by 30 years of service at Eli Lilly and Company which includes his service as Vice President of Sales Neuroscience from January 2006 to December 2011.

aptevotherapeutics.com aptevotherapeutics.com

ES210 (anti-CD86 x monoIL-10) : Aptevo

http://aptevotherapeutics.com/es210-anti-cd86-x-monoil-10

ES210 (anti-CD86 x monoIL-10). ES210 is a humanized, targeted cytokine therapeutic under development for the treatment of ulcerative colitis and has potential utility in multiple autoimmune diseases. ES210 was engineered using our bispecific ADAPTIR. Technology platform to deliver a modified form of the immunosuppressive cytokine IL-10 to antigen-presenting cells by targeting CD86. ES210 is designed to suppress T-cell responses through inhibition of antigen presentation. T-cell expansion measured as % hu...

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Aptevo Therapeutics and the ADAPTIR (Modular Protein Technology) Platform: The Future of Immuno-oncology. 160;  0.08 (3.21%). Updated January 13, 2017  4:00 pm ET. Stacey L. Jurchison. Senior Director, Investor Relations and Corporate Communications. Aptevo Therapeutics Inc at 29th Annual ROTH Conference. Aptevo Therapeutics Inc at the 16th Annual PEPTALK Conference. Aptevo Therapeutics Inc at Piper Jaffray 28th Annual Healthcare Conference.

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