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beanbag genomics

July 11, 2016. July 11, 2016. Tl;dr things cost money. It’s not news that most bioinformatics resources are short-lived. Websites mentioned in scientific papers go offline at about a rate of 5% per year. And even funding for extremely popular resources like the HapMap Browser. Can dry up effectively overnight. Indeed, researchers who work on model organisms are currently begging the National Institutes of Health. To continue supporting basic informatics infrastructure. Further, the most widely-used resou...

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beanbag genomics | joepickrell.wordpress.com Reviews
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July 11, 2016. July 11, 2016. Tl;dr things cost money. It’s not news that most bioinformatics resources are short-lived. Websites mentioned in scientific papers go offline at about a rate of 5% per year. And even funding for extremely popular resources like the HapMap Browser. Can dry up effectively overnight. Indeed, researchers who work on model organisms are currently begging the National Institutes of Health. To continue supporting basic informatics infrastructure. Further, the most widely-used resou...
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beanbag genomics | joepickrell.wordpress.com Reviews

https://joepickrell.wordpress.com

July 11, 2016. July 11, 2016. Tl;dr things cost money. It’s not news that most bioinformatics resources are short-lived. Websites mentioned in scientific papers go offline at about a rate of 5% per year. And even funding for extremely popular resources like the HapMap Browser. Can dry up effectively overnight. Indeed, researchers who work on model organisms are currently begging the National Institutes of Health. To continue supporting basic informatics infrastructure. Further, the most widely-used resou...

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In which I’m pretty sure I disagree with Lior Pachter and try to figure out why | beanbag genomics

https://joepickrell.wordpress.com/2015/06/11/in-which-im-pretty-sure-i-disagree-with-lior-pachter-and-try-to-figure-out-why

In which I’m pretty sure I disagree with Lior Pachter and try to figure out why. June 11, 2015. June 14, 2015. Note 6/14/15. Before reading this, see the comment thread here. I recently read a thoughtful blog post. By Lior Pachter on the importance of admitting errors in one’s work. There’s much to agree with in the post, but on first reading something seemed slightly off to me, though I couldn’t quite figure it out. In this section and I would prefer he be more direct. Lior takes aim at a paper with a b...

2

Y-chromosome “Adam” was not necessarily human | beanbag genomics

https://joepickrell.wordpress.com/2014/05/13/y-chromosome-adam-was-not-necessarily-human

Y-chromosome “Adam” was not necessarily human. May 13, 2014. May 13, 2014. Metaphors in science play an important role in communicating results from one field to scientists in other fields and to the general public. In some cases, however, metaphors are so successful and so appealing that they actually obscure rather than enlighten. In human population genetics, it is a simple fact that all of the Y chromosomes. I was reminded of this when reading over a paper. Mendez et al.] estimated the time to th...

3

In which I’m pretty sure I disagree with Lior Pachter and try to figure out why | beanbag genomics

https://joepickrell.wordpress.com/2015/06/11/in-which-im-pretty-sure-i-disagree-with-lior-pachter-and-try-to-figure-out-why/comment-page-1

In which I’m pretty sure I disagree with Lior Pachter and try to figure out why. June 11, 2015. June 14, 2015. Note 6/14/15. Before reading this, see the comment thread here. I recently read a thoughtful blog post. By Lior Pachter on the importance of admitting errors in one’s work. There’s much to agree with in the post, but on first reading something seemed slightly off to me, though I couldn’t quite figure it out. In this section and I would prefer he be more direct. Lior takes aim at a paper with a b...

4

beanbag genomics | Page 2

https://joepickrell.wordpress.com/page/2

Review: High Resolution Genomic Analysis of Human Mitochondrial RNA Sequence Variation. May 13, 2014. This post is part of an experiment where I will be posting summaries and critiques of the main points of papers I review for journals. Apologies in advance for any misunderstandings and errors on my end; please correct these in the comments. TL;DR: A clever analysis of RNA sequencing data identifies natural genetic variation influencing mitochondrial tRNA processing in humans. At 13 of the heteroplasmic ...

5

The burden of the “multiple testing burden” | beanbag genomics

https://joepickrell.wordpress.com/2014/10/22/the-burden-of-the-multiple-testing-burden

The burden of the “multiple testing burden”. October 22, 2014. October 22, 2014. I’ve written before. On this site about the way metaphors influence scientists and motivate entire directions of research. I was thinking about this again during talks at the meeting of the American Society for Human Genetics, where I was repeatedly reminded of that albatross hanging around the necks of anyone looking genome-wide for variants that influence disease risk: the “ multiple testing burden. But this makes no sense...

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beanbag genomics

July 11, 2016. July 11, 2016. Tl;dr things cost money. It’s not news that most bioinformatics resources are short-lived. Websites mentioned in scientific papers go offline at about a rate of 5% per year. And even funding for extremely popular resources like the HapMap Browser. Can dry up effectively overnight. Indeed, researchers who work on model organisms are currently begging the National Institutes of Health. To continue supporting basic informatics infrastructure. Further, the most widely-used resou...

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