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The Kislinger Proteomics Lab

The Kislinger Proteomics Lab. The human genome has been sequenced and now sophisticated technologies are used to characterize the proteome, the set of proteins generated by that genome, as a function of developmental stage, environment, tissue-type, and pathology. The goal of our research is to understand, on a systems level, the complex biological processes that are fundamental to physiology and disease. A particular focus of our laboratory is cancer research (ovarian and breast cancer) and vascular/cardio

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The Kislinger Proteomics Lab | kislingerlab.uhnres.utoronto.ca Reviews
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The Kislinger Proteomics Lab. The human genome has been sequenced and now sophisticated technologies are used to characterize the proteome, the set of proteins generated by that genome, as a function of developmental stage, environment, tissue-type, and pathology. The goal of our research is to understand, on a systems level, the complex biological processes that are fundamental to physiology and disease. A particular focus of our laboratory is cancer research (ovarian and breast cancer) and vascular/cardio
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4 instruments
5 collaborators
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7 thomas kislinger
8 professor and chair
9 erlangen germany
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The Kislinger Proteomics Lab | kislingerlab.uhnres.utoronto.ca Reviews

https://kislingerlab.uhnres.utoronto.ca

The Kislinger Proteomics Lab. The human genome has been sequenced and now sophisticated technologies are used to characterize the proteome, the set of proteins generated by that genome, as a function of developmental stage, environment, tissue-type, and pathology. The goal of our research is to understand, on a systems level, the complex biological processes that are fundamental to physiology and disease. A particular focus of our laboratory is cancer research (ovarian and breast cancer) and vascular/cardio

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The Kislinger Proteomics Lab

http://kislingerlab.uhnres.utoronto.ca/index.html

The Kislinger Laboratory is located at the Toronto Medical Discovery Tower of the Princess Margaret Cancer Centre, the largest oncology treatment and research facility in Canada. The major goal of our lab is to apply proteomics technologies to cancer and cardiovascular research. Our research interests include technology development, using the latest generation of mass spectrometry instrumentation, basic cell biology and translational cancer research. Thomas Kislinger, Ph.D. Princess Margaret Cancer Centre.

2

The Kislinger Proteomics Lab

http://kislingerlab.uhnres.utoronto.ca/instruments.html

Mass Spectrometry and protein purification instrumentation. We are well equipped with several mass spectrometers and HPLC units for protein purifications. Q Exactive Hybrid Quadrupole-Orbitrap (Thermo Scientific). Q Exactive HF Hybrid Quadrupole-Orbitrap (Thermo Scientific). Orbitrap Fusion Tribrid (Thermo Scientific).

3

The Kislinger Proteomics Lab

http://kislingerlab.uhnres.utoronto.ca/publications.html

Targeted proteomics identifies liquid-biopsy signatures for extracapsular prostate cancer. Kim Y, Jeon J, Mejia S, Yao CQ, Ignatchenko V, Nyalwidhe JO, Gramolini AO, Lance RS, Troyer DA, Drake RR, Boutros PC, Semmes OJ, Kislinger T. Nat Commun. 2016 Jun 28;7:11906. PTP1B controls non-mitochondrial oxygen consumption by regulating RNF213 to promote tumour survival during hypoxia. Nat Cell Biol. 2016 Jul;18(7):803-13. Scribble is required for pregnancy-induced alveologenesis in the adult mammary gland.

4

The Kislinger Proteomics Lab

http://kislingerlab.uhnres.utoronto.ca/projects.html

Head and Neck Cancer. We currently have a variety of head and neck cancer proteomics projects in the lab. These include the detailed analyses of archival FFPE tissues from oropharyngeal tumors to identify molecular pathways based on HPV-status and to identify genomic and proteomics signatures that predict the development of metastasis. Simona Principe (post-doc), Lusia Sepiashvili (PhD student), Javier Alfaro (PhD student), Salvador Mejia (technician). Yunee Kim (PhD student). Ankit Sinha (PhD student).

5

The Kislinger Proteomics Lab

http://kislingerlab.uhnres.utoronto.ca/people.html

Javier.Alfaro@oicr.on.ca.

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Skip to main content. U of T Main. Equity, Professionalism and Social Responsibility. Bachelor of Science in Medical Radiation Sciences. Application Requirements, Deadlines, and Procedures (MRS). MHSc in Medical Radiation Sciences. Admissions Criteria and Process. Program Format and Curriculum. Info for Current Residents. Info for Current Fellows. Student Life and Resources. Medical Students and Observers. Visiting and Elective Residents and Fellows. Accelerated Education Program - Courses. Biological re...

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The Kislinger Proteomics Lab

The Kislinger Laboratory is located at the Toronto Medical Discovery Tower of the Princess Margaret Cancer Centre, the largest oncology treatment and research facility in Canada. The major goal of our lab is to apply proteomics technologies to cancer and cardiovascular research. Our research interests include technology development, using the latest generation of mass spectrometry instrumentation, basic cell biology and translational cancer research. PhD, Friedrich-Alexander University in.

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