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HMS LINCS Project

Library of Integrated Network-based Cellular Signatures. Current listing of all journal articles published by HMS LINCS researchers. All mammalian cells respond to cytokines and growth factors present in the environment by activating immediate-early signaling pathways. Access a systematic dataset of ICBP43 cell line responses to diverse ligands. Access a systematic analysis of 50 cell lines to 64 anticancer drugs looking at different parameterizations of cell killing data measured at three days. We focus...

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HMS LINCS Project | lincs.hms.harvard.edu Reviews
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Library of Integrated Network-based Cellular Signatures. Current listing of all journal articles published by HMS LINCS researchers. All mammalian cells respond to cytokines and growth factors present in the environment by activating immediate-early signaling pathways. Access a systematic dataset of ICBP43 cell line responses to diverse ligands. Access a systematic analysis of 50 cell lines to 64 anticancer drugs looking at different parameterizations of cell killing data measured at three days. We focus...
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1 hms lincs project
2 explore
3 data
4 explore hms lincs
5 hms lincs publications
6 ligands as perturbagens
7 single cell dynamics
8 drugs as perturbagens
9 kinase inhibitor pathways
10 hms lincs database
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HMS LINCS Project | lincs.hms.harvard.edu Reviews

https://lincs.hms.harvard.edu

Library of Integrated Network-based Cellular Signatures. Current listing of all journal articles published by HMS LINCS researchers. All mammalian cells respond to cytokines and growth factors present in the environment by activating immediate-early signaling pathways. Access a systematic dataset of ICBP43 cell line responses to diverse ligands. Access a systematic analysis of 50 cell lines to 64 anticancer drugs looking at different parameterizations of cell killing data measured at three days. We focus...

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lincs.hms.harvard.edu lincs.hms.harvard.edu
1

Systematic analysis of BRAFV600E melanomas reveals a role for JNK/c-Jun pathway in adaptive resistance to drug-induced apoptosis - HMS LINCS Project

http://lincs.hms.harvard.edu/fallahi-sichani-molsystbiol-2015

Library of Integrated Network-based Cellular Signatures. Systematic analysis of BRAF. Melanomas reveals a role for JNK/c-Jun pathway in adaptive resistance to drug-induced apoptosis. Nathan J. Moerke. Nathanael S. Gray. And Peter K. Sorger. HMS LINCS Center, Harvard Medical School, Boston, MA;. Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA;. Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA. Doi: 10.15252/msb.20145877. Melanoma....

2

Fractional killing arises from cell-to-cell variability in overcoming a caspase activity threshold - HMS LINCS Project

http://lincs.hms.harvard.edu/roux-molsystbiol-2015

Library of Integrated Network-based Cellular Signatures. Fractional killing arises from cell-to-cell variability in overcoming a caspase activity threshold. Joshua J. Sims. And Peter K. Sorger. Department of Systems Biology, Harvard Medical School, Boston, MA;. Merrimack Pharmaceuticals, Cambridge, MA;. JR and MH contributed equally to this work. Doi: 10.15252/msb.20145584. A model of initiator caspase activity is predictive of fractional killing by TRAIL. Which presents plots of the smoothed single-cell...

3

HMS LINCS Database - HMS LINCS Project

http://lincs.hms.harvard.edu/db

Library of Integrated Network-based Cellular Signatures. Welcome to the HMS LINCS Database. The HMS LINCS Database is continuously being developed and expanded. The Database contains all publicly available HMS LINCS datasets and information for each dataset about experimental reagents (small molecule perturbagens, cells, antibodies, and proteins) and experimental and data analysis protocols. The HMS LINCS website. Also provides additional resources for many datasets. For the LINCS project. The LINCS data...

4

Experimental Methods - HMS LINCS Project

http://lincs.hms.harvard.edu/resources/methods

Library of Integrated Network-based Cellular Signatures. In addition to performing established biochemical and cell biological assays. The HMS LINCS Center participates in the development and improvement of cutting-edge experimental methods. The goal of the Center is to integrate these new methods into our adaptive data collection approach. The following list of methods developed by HMS LINCS will be updated regularly as our work progresses. CycIF, a high-throughput cyclic immunofluorescence method.

5

Metadata & Standards - HMS LINCS Project

http://lincs.hms.harvard.edu/data/metadata-standards

Library of Integrated Network-based Cellular Signatures. Metadata & Standards. Working with the LINCS Data Working Group (DWG), HMS LINCS is very active in helping to develop standards for the metadata describing LINCS reagents, assays, and experiments. Up-to-date versions of the metadata standards developed by the LINCS DWG and use cases that describe potential applications for LINCS data can be found on the LINCS Project website Data Standards. Additional HMS LINCS data formats and file types. Factor n...

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life.ccs.miami.edu life.ccs.miami.edu

Acknowledgement

http://life.ccs.miami.edu/life/acknowledgement

The University of Miami LINCS Center. Is a member of the LINCS Consortium. Supported by the NIH Common Fund. We gratefully acknowledge the following contributions:. The LINCS Data Production Centers (U54) and Technology Centers (U01) for taking the time to work with us and provide the data and metadata. Harvard Medical School (HMS) LINCS Center (U54). LINCS assays indexed in LIFEwrx: Apoptosis assay. Cell cycle state assay. Cell growth inhibition assay. Broad Institute LINCS Center (U54). Dr Shamu and te...

imc.hms.harvard.edu imc.hms.harvard.edu

About | HMS Image Management Core

http://imc.hms.harvard.edu/imc/about

Skip to main content. A service to help HMS researchers store, manage, and share microscope images. The Harvard Medical School Image Management Core is a new service of HMS Research IT Solutions. To help researchers manage image data and metadata. The IMC was created in response to the growing complexity and difficulty of managing research image data. The first major offering of the IMC will be a shared installation of the OMERO. And the Harvard Program in Therapeutic Science (HiTS). Boston, MA 02115.

hits.harvard.edu hits.harvard.edu

Harvard Program in Therapeutic Science

http://hits.harvard.edu/training-education

Harvard Program in Therapeutic Science. A Harvard University program based at Harvard Medical School. Training & Education. News & Events. Related Courses Workshops Nanocourses. Training & Education. Training opportunities offered by HiTS and the LSP will continue to expand over time to include not only certificates and short courses for graduate students, but also training workshops for industry professionals and courses open to the broader community. Graduate Program in Therapeutics.

hits.harvard.edu hits.harvard.edu

Harvard Program in Therapeutic Science

http://hits.harvard.edu/the-program/therapeutics-graduate-program

Harvard Program in Therapeutic Science. A Harvard University program based at Harvard Medical School. Training & Education. News & Events. Current Students and Alumni. Curriculum and Program Requirements. Electives and Other Related Courses. We are training pioneers. A new Certificate Program in Therapeutics. I can’t imagine a better program for learning the fundamentals of drug discovery and getting hands experience in industry. Not only will you understand the basics of therapeutic development, but...

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General Information

http://www.grcalculator.org/grtutorial

Drug sensitivity and resistance are quantified using IC. Values, but these metrics suffer from a fundamental flaw when applied to growing cells: they are highly sensitive to the number of divisions that take place over the course of a response assay (see the exploration tool below). Division rate varies across cell lines and experimental conditions. The dependency of IC. Are superior to IC. Illustration of the dependency of traditional metrics on division time. Are projected onto the x-axis; E. Are proje...

lincsproject.org lincsproject.org

NIH LINCS Program

http://www.lincsproject.org/news

Library of Integrated Network-Based Cellular Signatures. Data and Signature Generation Centers. BD2K-LINCS Data Coordination and Integration Center. Pilot Phase 1 Centers. Data Production and Analysis (U54). Tools & Databases. June 16th, 2016. Sherry Jenkins No Comments. By the Crowd Innovation Lab at Harvard, the Broad Institute, and NIH LINCS Program. The LINCS Center for Transcriptomics. Registration is open at. Http:/ crowdsourcing.topcoder.com/cmap. June 2nd, 2016. Sherry Jenkins No Comments. Side e...

lincsproject.org lincsproject.org

Webinars - NIH LINCS Program

http://www.lincsproject.org/community/webinars

Library of Integrated Network-Based Cellular Signatures. Data and Signature Generation Centers. BD2K-LINCS Data Coordination and Integration Center. Pilot Phase 1 Centers. Data Production and Analysis (U54). Tools & Databases. LINCS Data Science Research (DSR) Webinars. The LINCS Data Science Research Webinars serve as a general forum to engage data scientists within and outside of the LINCS project to work on problems related to LINCS data analysis and integration. Webinars are held on. November 29, 2016.

life.ccs.miami.edu life.ccs.miami.edu

Life help

http://life.ccs.miami.edu/life/help

The LIFE search engine. Integrates all LINCS content leveraging a semantic knowledge model and common LINCS metadata standards. LIFE makes LINCS content discoverable and includes aggregate results linked to the Harvard Medical School. And other LINCS centers, who provide more information including experimental conditions and raw data. How do you search LIFE? LIFEwrx can be search by free text, using visualizations like the sunburst and hierarchical browsing and by drawing a chemical structure.

hits.harvard.edu hits.harvard.edu

Harvard Program in Therapeutic Science

http://hits.harvard.edu/the-program/program-in-regulatory-science

Harvard Program in Therapeutic Science. A Harvard University program based at Harvard Medical School. Training & Education. News & Events. Regulatory Science Think Tank. The goal of regulatory science is to make innovations that get to patients better, faster and cheaper. There is broad agreement that our current system is broken . Today approximately 70% of the cost of drug development can be attributed to past failures. Only 10-15% is used to produce effective therapies. One opportunity involves areas ...

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OTHER SITES

lincs.ed.gov lincs.ed.gov

LINCS | Adult Education and Literacy | U.S. Department of Education

Skip to main content. Community, Courses, and Resources for Adult Education. Adult Career Pathways Online Courses. English Language Learner University (ELL-U). English Language Learner University (ELL-U). Integrating Digital Literacy into English Language Instruction. Meeting the Language Needs of Today's English Language Learner. Open Educational Resources (OER) for English Language Instruction. Preparing English Learners for Work and Career Pathways. Teacher Effectiveness in Adult Education. Through th...

lincs.etsmtl.ca lincs.etsmtl.ca

Laboratoire d'ingénierie Cognitive Sémantique: Accueil

Bienvenue sur le site du LiNCS. Les principaux axes de recherche du laboratoire portent sur l'analyse et l'interprétation sémantique des changements dans les conditions physiques et cognitives des personnes souffrant d'une maladie ou ayant été déstabilisées par des bouleversements sociaux ou environnementaux. Ces axes se déploient dans deux contextes, a) le contexte médical et clinique; b) le contexte social, comme en témoigne les projets en cours au laboratoire. De l'ÉTS (dirigé par le professeur Luc Du...

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How to Log in or Sign up. If you are a new external user, you can create an account using the LOG IN/SIGN UP option below. If you already have an account and wish to log in please select the LOG IN button. If you log in before you complete a form; after you submit you will be able to view your saved or submitted forms using the My Forms button. Internal Users (@lincolnshire.gov.uk):. If you are an internal user and wish to log in please select the LOG IN (FAM) button. LOG IN / SIGN UP.

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Laboratory of Information, Networking and Communication Sciences

Laboratory of Information, Networking and Communication Sciences. Content Distribution and Content Services. Internet of Things, Smart Spaces, WSAN. Former invited professors and researchers. Welcome to the Laboratory of Information, Networking and Communication Sciences (LINCS). The LINCS is a research centre, co-founded by Inria. And Nokia Bell Labs. Dedicated to research and innovation in the domains of future information and communication networks, systems and services. In 2014 SystemX. To work on co...

lincs.gu.se lincs.gu.se

Startpage - LinCS, University of Gothenburg, Sweden

Read more about how we use cookies on gu.se. The Linnaeus Centre for Research on Learning, Interaction and Mediated Communication in Contemporary Society (LinCS). LinCS also runs a national research school (LinCS-DSES). A videolab facility (LinCS-Lab). And participates in a range of international networks. In the field of learning and media. Research Council (www.vr.se). University of Gothenburg (www.gu.se). IT Faculty (University of Gothenburg) (www.itufak.gu.se). Doctoral School in Educational Sciences.

lincs.hms.harvard.edu lincs.hms.harvard.edu

HMS LINCS Project

Library of Integrated Network-based Cellular Signatures. Current listing of all journal articles published by HMS LINCS researchers. All mammalian cells respond to cytokines and growth factors present in the environment by activating immediate-early signaling pathways. Access a systematic dataset of ICBP43 cell line responses to diverse ligands. Access a systematic analysis of 50 cell lines to 64 anticancer drugs looking at different parameterizations of cell killing data measured at three days. We focus...

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Sign in with Facebook. What our members say! Lincshare is a free carsharing 'matching service' for all those who live, work and travel around Lincolnshire. Is the car your main mode of travel to work? Here are a few reasons why you should consider car-sharing your journey:. Save money by splitting car costs, such as car parking and fuel. Car sharing reduces your CO2 emissions. Fewer cars on the road will make your journey quicker. Increase security: it's safer to travel in 2s or more.

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