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Structural Characterization of Macromolecular Assemblies. Using NMR and X-ray crystallography we are currently characterizing the interactions of Smad proteins and cofactors with DNA promoters, to provide a first understanding of how these molecular machines work and to pave the basis for the design of small molecular inhibitors specifically targeted towards tumor-derived Smad forms. Structural characterization of macromolecular assemblies. IRB Barcelona - Institute for Research in Biomedicine, 01B41.

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Maria Macias Hernandez

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ES

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Structural Characterization of Macromolecular Assemblies. Using NMR and X-ray crystallography we are currently characterizing the interactions of Smad proteins and cofactors with DNA promoters, to provide a first understanding of how these molecular machines work and to pave the basis for the design of small molecular inhibitors specifically targeted towards tumor-derived Smad forms. Structural characterization of macromolecular assemblies. IRB Barcelona - Institute for Research in Biomedicine, 01B41.
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About us | Macias Group | maciasnmr.net Reviews

https://maciasnmr.net

Structural Characterization of Macromolecular Assemblies. Using NMR and X-ray crystallography we are currently characterizing the interactions of Smad proteins and cofactors with DNA promoters, to provide a first understanding of how these molecular machines work and to pave the basis for the design of small molecular inhibitors specifically targeted towards tumor-derived Smad forms. Structural characterization of macromolecular assemblies. IRB Barcelona - Institute for Research in Biomedicine, 01B41.

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About the Consortium

Skip to main navigation. Skip to first column. Skip to second column. Welcome to the web page of RNAREG! RNAREG is a consortium of research groups financed by the Consolider Ingenio Program from the Spanish Ministry of Science and Innovation for the period 2010-2015. The focus of the consortium is the study of post-transcriptional regulation of gene expression and the impact of de-regulation of these processes in human disease, particularly in cancer. Felipe Prosper (associated group).

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About us | Macias Group

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Structural Characterization of Macromolecular Assemblies. We study how Smad proteins and bound cofactors assemble and read DNA, to correlate cell signaling with gene expression. Smad7 recruits the ubiquitin ligases Nedd4L, Smurf1 and Smurf2 to mediate TGF beta receptor polyubiquitination and degradation by endocytosis. As with R-SMADS, all these interactions involve the linker region of Smad7 that contains a PY motif and the WW domain regions of Nedd4L, Smurf1/2, and YAP. Baldiri Reixac, 10.

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Structural Characterization of Macromolecular Assemblies. Using NMR and X-ray crystallography we are currently characterizing the interactions of Smad proteins and cofactors with DNA promoters, to provide a first understanding of how these molecular machines work and to pave the basis for the design of small molecular inhibitors specifically targeted towards tumor-derived Smad forms. Structural characterization of macromolecular assemblies. IRB Barcelona - Institute for Research in Biomedicine, 01B41.

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