mgddk1.niddk.nih.gov

Molecular Recognition Section : NIDDK

Welcome to the home page of the Molecular Recognition Section. The section was created officially in 1993 by Dr. Kenneth A. Jacobson. Is dedicated to the application of knowledge-based drug design and discovery. It encompasses pharmacology. Our main focus is on purinoceptors. G protein-coupled receptors and ligand-gated ion channels for adenosine. And other nucleotides), but we work on other topics as well. One of our projects is a database of G protein-coupled receptor (GPCR). Building 8A, Room B1A17.

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Molecular Recognition Section : NIDDK | mgddk1.niddk.nih.gov Reviews

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Welcome to the home page of the Molecular Recognition Section. The section was created officially in 1993 by Dr. Kenneth A. Jacobson. Is dedicated to the application of knowledge-based drug design and discovery. It encompasses pharmacology. Our main focus is on purinoceptors. G protein-coupled receptors and ligand-gated ion channels for adenosine. And other nucleotides), but we work on other topics as well. One of our projects is a database of G protein-coupled receptor (GPCR). Building 8A, Room B1A17.

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Molecular Recognition Section : NIDDK | mgddk1.niddk.nih.gov Reviews

https://mgddk1.niddk.nih.gov

Welcome to the home page of the Molecular Recognition Section. The section was created officially in 1993 by Dr. Kenneth A. Jacobson. Is dedicated to the application of knowledge-based drug design and discovery. It encompasses pharmacology. Our main focus is on purinoceptors. G protein-coupled receptors and ligand-gated ion channels for adenosine. And other nucleotides), but we work on other topics as well. One of our projects is a database of G protein-coupled receptor (GPCR). Building 8A, Room B1A17.

INTERNAL PAGES

mgddk1.niddk.nih.gov

1

Computational Chemistry : Molecular Recognition Section : NIDDK

https://mgddk1.niddk.nih.gov/compchem.shtml

An Introduction to Modelling G Protein-Coupled Receptors. This page describes the current research in our lab to better understand the molecular mechanisms involved in receptor-ligand interactions. For this purpose we use. This particular page is an excerpt from a publication:. Van Rhee, am; Fischer, B. Jacobson, K.A. Purinoceptor using rhodopsin as template. Which describes how we approached the problem of visualizing the molecular architecture of the G protein-coupled P2Y. Have been shown to be useful ...

2

Staff : Molecular Recognition Section : NIDDK

https://mgddk1.niddk.nih.gov/staff.shtml

Molecular Recognition Section Staff. Dr Kenneth A. Jacobson. BA, Reed College (USA), 1976. PhD, Chemistry, University of California, San Diego (USA), 1981. Professor, Gangxi Inst. of Pharmacy (China). MD, Kiev State Medical School (Russia), 1947. PhD, Medical Inst. of Kiev (Russia), 1951. Visiting Scientists and Post-docs. Dr Philip van Galen. MS, Pharmacy, University of Utrecht (The Netherlands). PhD, Medicinal Chemistry, University of Leiden (The Netherlands). MS, Molecular Biology. Dr Ivar von Kugelgen.

3

G Protein-Coupled Receptors : Molecular Recognition Section : NIDDK

https://mgddk1.niddk.nih.gov/GPCR.shtml

Welcome to the G Protein-Coupled Receptor Main Page of the Molecular Recognition Section. Although our section is mainly involved in investigating the Molecular Recognition process between purinoceptors. And their ligands, we are interested in all aspects of Molecular Recognition. Since all currently known P. Are members of the protein family commonly known as G Protein-Coupled Receptors (GPCRs), we have collected a fair amount of data on GPCRs. These data are organized in three sections:. Which is part ...

4

Pharmacology : Molecular Recognition Section : NIDDK

https://mgddk1.niddk.nih.gov/pharmacol.shtml

This is a sensitive map. You may click on any item within the blue border to follow the link. The overall sequence homology between P. Purinoceptors is less than 20%. Chief: Dr. Kenneth Jacobson. The Molecular Recognition Section (MRS) is in the Laboratory of Bioorganic Chemistry. At the National Institute of Diabetes and Digestive and Kidney Diseases. Which is part of the National Institutes of Health.

5

Molecular Recognition Section : Molecular Recognition Section : NIDDK

https://mgddk1.niddk.nih.gov/adenosine.shtml

The pharmacology and selective ligands for these receptors. Are described on a separate page. This page is a digest of previous and current work on the human A. Adenosine receptor in our lab. To find out more about the origin of the work presented here, please have a look at. Kim, J. Wess, J. van Rhee, am; Schöneberg, T. Jacobson, K.A. Site-directed mutagenesis identifies residues involved in ligand recognition in the human A. Adenosine receptor. J. Biol. Chem. First, a fly-by shot of the A. On the oppos...

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mgddk1.niddk.nih.gov

Molecular Recognition Section : NIDDK

Welcome to the home page of the Molecular Recognition Section. The section was created officially in 1993 by Dr. Kenneth A. Jacobson. Is dedicated to the application of knowledge-based drug design and discovery. It encompasses pharmacology. Our main focus is on purinoceptors. G protein-coupled receptors and ligand-gated ion channels for adenosine. And other nucleotides), but we work on other topics as well. One of our projects is a database of G protein-coupled receptor (GPCR). Building 8A, Room B1A17.

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