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Science/AAAS and modENCODE | modENCODE Education Suppplement

Why we study model organisms to understand the human body, presented by Science and modENCODE

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Science/AAAS and modENCODE | modENCODE Education Suppplement | modencode.sciencemag.org Reviews
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Why we study model organisms to understand the human body, presented by Science and modENCODE
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2 drosophila
3 c elegans
4 transcription
5 chromatin
6 genomics
7 bioinformatics
8 glossary
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10 teacher's guide
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modencode,drosophila,c elegans,transcription,chromatin,genomics,bioinformatics,glossary,navigation,teacher's guide,site authors/contributors,the modules,adult,transcription regulation,image credits,drosophila melanogaster,caenorhabditis elegans,project
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Science/AAAS and modENCODE | modENCODE Education Suppplement | modencode.sciencemag.org Reviews

https://modencode.sciencemag.org

Why we study model organisms to understand the human body, presented by Science and modENCODE

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1

modENCODE | Appendix

http://modencode.sciencemag.org/appendix/glossary

A short, fat, right-handed form of the DNA double helix. This is a largely dehydrated form. Because the base pairs are pushed out from the axis, and tilted relative to the axis, this form can accommodate RNA, either in a DNA-RNA hybrid or an RNA-RNA double helix. That part of a transcription factor which is responsible for the increase in transcription observed on binding of the factor to the DNA control region of a particular gene. Adenine, guanine, cytosine, thymine:. A reversible change in protein con...

2

modENCODE | Worm as a model organism

http://modencode.sciencemag.org/worm/introduction

As a Model Organism An Introduction. In this section, you will:. Find out about what makes the worm. Like the fruit fly, a successful model organism - and about some of the worm's unique and unusual advantages for many studies. Drill down into three. That look at the worm as a model in studies of aging and programmed cell death, and at how RNA interference is used to churn out new and useful mutant copies for the lab. Take a number of. Consider and answer a series of. Some of the most plentiful. As a mod...

3

modENCODE | Drosophila as a model organism

http://modencode.sciencemag.org/drosophila/introduction

As a Model Organism An Introduction. Image Source: Photo by André Karwath/Wikimedia Commons. In this section, you will:. Learn about the fruit fly. And, in particular, what has made it such a spectacular success as a model system for biological investigations. Explore how studies of the fly have been used to investigate the roots of human diseases and disorders, from alcoholism to Alzheimer's, through a series of. Take a number of. To external sites to deepen your understanding. Studying these genes in.

4

modENCODE | Chromatin

http://modencode.sciencemag.org/chromatin/introduction

Chromatin Getting a Lot of Information into a Small Package. Image Source: P. J. Horn and C. L. Peterson,. In this section, you will:. Learn how the cell packs six feet of DNA into a nucleus 5 micrometers in length, through the amazing structure known as chromatin. Begin to decipher the histone code and the mechanisms, beyond transcription, by which the expression of genes is regulated. Explore how the modENCODE project has expanded our understanding of how chromatin states affect gene expression, in a.

5

modENCODE |

http://modencode.sciencemag.org/genomics/genomics

Genomics Digging into the A's, C's, G's, T's, and U's of It All. Image Source: modENCODE Consortium. In this section, you will:. Learn about how high-throughput technologies, such as next-generation sequencing, have revolutionized molecular biology and created entirely new disciplines. To explore how sequencing is done today. Investigate some techniques for drilling down into the mechanisms of transcription and gene regulation that were crucial to the modENCODE project. Answer a set of. As the name impli...

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External Resources | Genomics Education Partnership

http://gep.wustl.edu/curriculum/external_resources

Skip to main content. Sponsored by Washington University in St. Louis, HHMI and NSF. This page contains links to publicly available bioinformatics tutorials and other training materials. Links to External Resources. Bioinformatics Tutorial Series (BITS). Video tutorials on using the UCSC Genome Browser, BLAST and NCBI Entrez. Educational Resources for Epigenetics. Video on Epigenetics, which provides the same material in a 13 minute video narrated by Neil deGrasse-Tyson. Note that the chromatin model...

heterochromatin.blogspot.com heterochromatin.blogspot.com

Drosophila Heterochromatin: May the Fourth Be With You: August 2014

http://heterochromatin.blogspot.com/2014_08_01_archive.html

Drosophila Heterochromatin: May the Fourth Be With You. Friday, August 29, 2014. The Eyes Have It: The Drosophila eye as a model for understanding gene expression regulation. Male a Female Fruit Flies. Cartoon Via WikiHow. 1965 by Srb et a. . all text material ©2006 by. Steven M. Carr. From left to right: Red eyed, wild-type fly eye; Fly with non-functional white gene; Fly eye exhibiting position effect variegation (PEV). Subscribe to: Posts (Atom). Model Organisms and Modern Biology.

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Drosophila Heterochromatin: May the Fourth Be With You: December 2014

http://heterochromatin.blogspot.com/2014_12_01_archive.html

Drosophila Heterochromatin: May the Fourth Be With You. Tuesday, December 9, 2014. So after many attempts and re-workings, new primer sets and fresh enzymes, plates with colonies and negative cultures, we decided that the LacZ fusion was not going to work and devoting any more time to it did not make sense. We still needed a mechanism for visualizing Rad23 expression at our fourth chromosome heterochromatin site. A visual marker, like the white. There has not yet been work done on the Drosophila Rad23.

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Drosophila Heterochromatin: May the Fourth Be With You: February 2014

http://heterochromatin.blogspot.com/2014_02_01_archive.html

Drosophila Heterochromatin: May the Fourth Be With You. Sunday, February 9, 2014. Packing it in: DNA and its place in the nucleus. Attribution: Darryl Leja, NHGRI. The Nucleosome. Attribution: Richard Wheeler. This combination of DNA and associated proteins is known as chromatin and it is chromatin that allows for fine-tuned regulation of gene expression. Both DNA and histones in chromatin are the targets of modifications. By adding methyl or acetyl groups to the ends of histone molecules, the so-called ...

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Drosophila Heterochromatin: May the Fourth Be With You: Changing Course

http://heterochromatin.blogspot.com/2014/12/changing-course.html

Drosophila Heterochromatin: May the Fourth Be With You. Tuesday, December 9, 2014. So after many attempts and re-workings, new primer sets and fresh enzymes, plates with colonies and negative cultures, we decided that the LacZ fusion was not going to work and devoting any more time to it did not make sense. We still needed a mechanism for visualizing Rad23 expression at our fourth chromosome heterochromatin site. A visual marker, like the white. There has not yet been work done on the Drosophila Rad23.

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Drosophila Heterochromatin: May the Fourth Be With You: How do genes on the fourth chromosome of Drosophila melanogaster get expressed?

http://heterochromatin.blogspot.com/2014/09/how-do-genes-on-fourth-chromosome-of.html

Drosophila Heterochromatin: May the Fourth Be With You. Friday, September 5, 2014. How do genes on the fourth chromosome of Drosophila melanogaster get expressed? The fourth chromosome of Drosophila melanogaster. Also referred to as the dot chromosome and the Muller F element, is tiny compared to the other chromosomes that comprise the Drosophila. Drosophila Chromosomes. Can you find the fourth chromosome? We postulate that genes on the fourth chromosome have evolved a mechanism that allows them to be ex...

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Introducing Genes | Genomics Education Partnership

http://gep.wustl.edu/curriculum/introducing_genes

Skip to main content. Sponsored by Washington University in St. Louis, HHMI and NSF. GEP Digital Laboratory Notebook. The "Understanding Eukaryotic Genes" curriculum has been developed by Elena Gracheva, Carina Howell, Cathy Silver Key, Margaret Laakso, Leocadia Paliulis, Maria Santisteban, Chiyedza Small, and Joyce Stamm. We would also like to thank additional members of the GEP who helped to review and revise these materials. All the modules listed below are also available in a. This workflow provides ...

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Drosophila Heterochromatin: May the Fourth Be With You: The Plan

http://heterochromatin.blogspot.com/2014/09/the-plan.html

Drosophila Heterochromatin: May the Fourth Be With You. Friday, September 12, 2014. Here's a flowchart illustrating the question we're asking and approach we're taking. Subscribe to: Post Comments (Atom). Model Organisms and Modern Biology. Washington University in St. Louis. How do genes on the fourth chromosome of Drosophil. View my complete profile. 2014 Washington University in St. Louis. Awesome Inc. template. Powered by Blogger.

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Educational Resources - SGD-Wiki

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Note on editing these wiki tables. Classroom and Course Materials. Note on editing these wiki tables. When editing this page, please refer to the comment line at the top of each table if you need assistance in creating a row, or please feel free to mail us at sgd-helpdesk@lists.stanford.edu. And we would be happy to help you with the post. National Science Teachers Association. Books, Resources, Conferences, Science Standards for Educators at all academic levels (K- Undergraduate). General Biology and Ge...

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modENCODE

The National Human Genome Research Institute. The modENCODE Project will try to identify all of the sequence-based functional elements in the Caenorhabditis elegans. Genomes. ”. A hierarchical view of regulatory networks. For fly and worm. Your genomic regions and search for features found by the modENCODE. Your list of fly genes and view an expression score heatmap. The entire modENCODE data set available for analysis in the Amazon compute cloud. Find, view and download datasets in bulk. Developmental s...

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Science/AAAS and modENCODE | modENCODE Education Suppplement

Model Organisms and Modern Biology An educational portal from the modENCODE Project. Module 1: Model Organisms in Biology. Why we study flies and worms to learn about humans - and what we've learned so far. [More info]. The lowly fruit fly - easy to grow and maintain, with giant chromosomes and some surprising genetic similarities to humans - has been at the core of biological research for more than 100 years. Module 2: Model Organisms and Gene Expression. Module 3: The Role of Computers and Technology.

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Science/AAAS and modENCODE | modENCODE Education Suppplement

Model Organisms and Modern Biology An educational portal from the modENCODE Project. Module 1: Model Organisms in Biology. Why we study flies and worms to learn about humans - and what we've learned so far. [More info]. The lowly fruit fly - easy to grow and maintain, with giant chromosomes and some surprising genetic similarities to humans - has been at the core of biological research for more than 100 years. Module 2: Model Organisms and Gene Expression. Module 3: The Role of Computers and Technology.

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