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MutationAssessor.org /// functional impact of protein mutations

Mutation assessor .org. Functional impact of protein mutations. This server predicts the functional impact of amino-acid substitutions in proteins, such as mutations discovered in cancer or missense polymorphisms. The functional impact is assessed based on evolutionary conservation of the affected amino acid in protein homologs. The method has been validated. Dec 31, 2015. All scores for human Swiss-Prot sequences are available:. MA scores rel3 swissprot full.tar.gz. Or split to parts of up to 1M records).

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MutationAssessor.org /// functional impact of protein mutations | mutationassessor.org Reviews
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Mutation assessor .org. Functional impact of protein mutations. This server predicts the functional impact of amino-acid substitutions in proteins, such as mutations discovered in cancer or missense polymorphisms. The functional impact is assessed based on evolutionary conservation of the affected amino acid in protein homologs. The method has been validated. Dec 31, 2015. All scores for human Swiss-Prot sequences are available:. MA scores rel3 swissprot full.tar.gz. Or split to parts of up to 1M records).
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3 papers
4 changes
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6 web api
7 is out
8 enter your mutations
9 or use example
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MutationAssessor.org /// functional impact of protein mutations | mutationassessor.org Reviews

https://mutationassessor.org

Mutation assessor .org. Functional impact of protein mutations. This server predicts the functional impact of amino-acid substitutions in proteins, such as mutations discovered in cancer or missense polymorphisms. The functional impact is assessed based on evolutionary conservation of the affected amino acid in protein homologs. The method has been validated. Dec 31, 2015. All scores for human Swiss-Prot sequences are available:. MA scores rel3 swissprot full.tar.gz. Or split to parts of up to 1M records).

LINKS TO THIS WEBSITE

provean.jcvi.org provean.jcvi.org

PROVEAN Links

http://provean.jcvi.org/links.php

Human genome asssembly GRCh37. Other variant prediction tools:. J Craig Venter Institute. 124; Privacy Statement. 124; Data Disclaimer.

rvs.u.hpc.mssm.edu rvs.u.hpc.mssm.edu

RVS — the Reference Variant Store

https://rvs.u.hpc.mssm.edu/about.php

Information provided by RVS. RVS currently contains more than 520 million variants, obtained from these studies:. 1000 Genomes Phases 1 and 3 (1092 and 2535 samples, respectively; WGS). ESP6500 (6503 samples, WES). Scripps Wellderly (534, WGS). UK10K (7320: 4888 WES and 2432 WGS). GERA ( 78,000, genotyping). TCGA (4415, mixed WES and WGS). Mt Sinai BioBank (11,210, genotyping; visible to Mount Sinai users only). And these sample-independent resources and annotation databases:. Information provided by RVS.

rvs.u.hpc.mssm.edu rvs.u.hpc.mssm.edu

Disease Variant Store

https://rvs.u.hpc.mssm.edu/divas

The Disease Variant Store provides information on genetic variants observed in various disease populations. Users can quickly obtain frequencies, functional annotations, and known disease annotations by performing simple queries. DIVAS is currently based on the following sequencing and genotyping studies:. For all functional impact annotations, using GRCh37.75 as the reference genome. We also provide predictions based on various tools, such as SIFT. DIVAS contains variants for 58434.

umd-predictor.eu umd-predictor.eu

UMD-Predictor

http://www.umd-predictor.eu/index.php

In order to use UMD Predictor you need to have a validated account or register. UMD-Predictor is freely available for non-commercial users. Nevertheless it is not allowed to copy all or part of the database content without specific authorisation from us. If you are a commercial user. Please contact us to obtain a dedicated license. For more information please contact Prof. Christophe Béroud. Or Dr David Salgado. UMD-Predictor: A mutation pathogenicity prediction system. As underlined by Pabinger et al.

bg.upf.edu bg.upf.edu

Computational Oncogenomics

http://bg.upf.edu/blog

The biomedical genomics blog. Our paper demonstrating that proteins bound to DNA impair Nucleotide Excision Repair published in Nature. I am very happy to announce that our manuscript describing the increased mutation rate in Transcription Factor Binding Sites (TFBS) in melanomas and lung tumors has been published in today’s issue of Nature. In the manuscript we demonstrate that this accumulation is due to the impairment of Nucleotide Excision Repair (NER) activity by proteins bound to DNA. Where all dat...

cbio.mskcc.org cbio.mskcc.org

Cancer Genomics | cBio@MSKCC

http://cbio.mskcc.org/tools/cancer-genomics/index.html

Memorial Sloan-Kettering Cancer Center. Prostate Cancer Signaling Pathways. Prostate Cancer Additional Data. Sarcoma (MSKCC / Broad). Glioblastoma DNA Copy Number. Leslie Research Group Tools. Pathways & Networks. Software Engineer: Sander Group. Postdoc: Sander Group (Cancer Genomics). Senior Software Engineer: Bioinformatics Core. UNIX Systems Administrator: Bioinformatics Core and Molecular Pathology. Laura de Vargas Roditi. Vipin T. Sreedharan. Neeraj Harikrishna Girija Paramasivam. All features of t...

cbioportal.org cbioportal.org

cBioPortal for Cancer Genomics::Web Interface

http://www.cbioportal.org/web_api.jsp

What cancer studies are stored on the server? What genetic profile types are available for cancer study X? For example, does the server store mutation and copy number data for the TCGA Glioblastoma data? What case sets are available for cancer study X? For example, what case sets are available for TCGA Glioblastoma? Additionally, clients can easily retrieve "slices" of genomic data. For example, a client can retrieve all mutation data from PTEN and EGFR in the TCGA Glioblastoma data. The CGDS R Package.

umd-predictor.eu umd-predictor.eu

UMD-Predictor

http://www.umd-predictor.eu/analysis.php

You are not logged in. Please log in or register to use UMD-Predictor. In order to use UMD Predictor you need to have a validated account or register. UMD-Predictor is freely available for non-commercial users. Nevertheless it is not allowed to copy all or part of the database content without specific authorisation from us. If you are a commercial user. Please contact us to obtain a dedicated license. For more information please contact Prof. Christophe Béroud. Or Dr David Salgado. Legal issues might ari...

provean.jcvi.org provean.jcvi.org

PROVEAN About

http://provean.jcvi.org/about.php

This work is funded by National Institutes of Health grant number 5R01HG004701-03. Choi Y, Sims GE, Murphy S, Miller JR, Chan AP (2012) Predicting the Functional Effect of Amino Acid Substitutions and Indels. PLoS ONE 7(10): e46688. Choi Y (2012) A Fast Computation of Pairwise Sequence Alignment Scores Between a Protein and a Set of Single-Locus Variants of Another Protein. In Proceedings of the ACM Conference on Bioinformatics, Computational Biology and Biomedicine. Overview - PROVEAN ( Pro. Is computed...

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MutationAssessor.org /// functional impact of protein mutations

Mutation assessor .org. Functional impact of protein mutations. This server predicts the functional impact of amino-acid substitutions in proteins, such as mutations discovered in cancer or missense polymorphisms. The functional impact is assessed based on evolutionary conservation of the affected amino acid in protein homologs. The method has been validated. Dec 31, 2015. All scores for human Swiss-Prot sequences are available:. MA scores rel3 swissprot full.tar.gz. Or split to parts of up to 1M records).

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Mutation Chinchilla Breeders Association - Home

Mutation Chinchilla Breeders Association. National Board Of Directors. State and Regional Chapters. Quality standards for all variations of chinchillas are set with emphasis on increasing and maintaining a high standard of excellence in the industry. Regularly scheduled seminars and show competitions with experienced judges are held to educate the breeders and compare their animals with others throughout the country. We Need Your Help! Send all inquires to Kyle Lemler at lemlerchinchillas @yahoo.com.

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Mutation Chinchilla Breeders Association - Home

Mutation Chinchilla Breeders Association. National Board Of Directors. State and Regional Chapters. Quality standards for all variations of chinchillas are set with emphasis on increasing and maintaining a high standard of excellence in the industry. Regularly scheduled seminars and show competitions with experienced judges are held to educate the breeders and compare their animals with others throughout the country. We Need Your Help! Send all inquires to Kyle Lemler at lemlerchinchillas @yahoo.com.