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Uncategorized | The Heterocyclist
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A blog about heterocyclic chemistry. RSS for this section. April 29, 2013. Pd(II)-Catalyzed Dehydrogenative Cyclizations of. Near-simultaneous reports of an interesting new pyrrole (and dihydropyrrole) synthesis have appeared recently from the labs of Frank Glorius (Westfälische Wilhelms-Universität Münster). And Naohiko Yoshikai (Nanyang Technologial University, Singapore). The scope of the reaction is decent, as indicated below. Failures include R. Or cyclopropyl and R. February 4, 2013. I keep it upda...
heterocyclist.com
Pd(II)-Catalyzed Dehydrogenative Cyclizations of N-Allylimines | The Heterocyclist
https://heterocyclist.com/2013/04/29/pdii-catalyzed-dehydrogenative-cyclizations-of-n-allylimines
A blog about heterocyclic chemistry. April 29, 2013. Pd(II)-Catalyzed Dehydrogenative Cyclizations of. Near-simultaneous reports of an interesting new pyrrole (and dihydropyrrole) synthesis have appeared recently from the labs of Frank Glorius (Westfälische Wilhelms-Universität Münster). And Naohiko Yoshikai (Nanyang Technologial University, Singapore). The scope of the reaction is decent, as indicated below. Failures include R. Or cyclopropyl and R. Cinnamyl imines were also unsuccessful. Notify me of n...
kentuckychemistry.wordpress.com
On the Similarities Between Sucralose and DDT | Kentucky Chemistry
https://kentuckychemistry.wordpress.com/2013/05/01/on-the-similarities-between-sucralose-and-ddt
A Kentuckian, an Engineer, and a Chemist. On the Similarities Between Sucralose and DDT. May 1, 2013. Like everyone else. If we work in research, we are only interested in the results and we will report the results with the utmost integrity. One major example of the distrust of scientists is the belief that. Are bad (m’kay). In fact, many bands have gone out of their way to note that they are chemical free. We call this irrational fear of all things. When compared to ‘bad’ chemicals. High profile ‘...
kentuckychemistry.wordpress.com
On Tossing Cigarettes at Gasoline for #ChemMovieCarnival | Kentucky Chemistry
https://kentuckychemistry.wordpress.com/2013/04/19/on-tossing-cigarettes-at-gasoline-for-chemmoviecarnival
A Kentuckian, an Engineer, and a Chemist. On Tossing Cigarettes at Gasoline for #ChemMovieCarnival. April 19, 2013. For those of you that don’t know, next week is #RealTimeChem week. To kick off the event, blogger See Arr Oh (obviously not their real name) called for chemistry bloggers. To take their favorite chemistry moments from movies and write up a post. Originally, I called dibs on cold-fusion and the movie. So I was watching every movie in my collection and eventually got to. Experiments. I am...
kentuckychemistry.wordpress.com
On the Development of a Method for Dish Sanitization | Kentucky Chemistry
https://kentuckychemistry.wordpress.com/2013/03/27/on-the-development-of-a-method-for-dish-sanitization
A Kentuckian, an Engineer, and a Chemist. On the Development of a Method for Dish Sanitization. March 27, 2013. Sorry for the super late post – I was on vacation. My best friends were getting married and I wanted to devote my full attention to them. I’ll try and post again soon to make up for the wait. Thank goodness this isn’t my kitchen! Does it really get my dishes that much cleaner? Does it just remove food and grease? Does it kill germs? There’s a saying in chemistry:. To explain this, we need to ad...
heterocyclist.com
Name Reactions | The Heterocyclist
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A blog about heterocyclic chemistry. RSS for this section. August 6, 2015. Regioselective synthesis of 3- and 5-aminopyrazoles. Just a bit of sodium ethoxide does the trick …. Wouldn’t it be nice to be able to produce either the 3- or 5-aminopyrazole regioisomer in a selective fashion? From Boehringer Ingelheim is a most welcome arrival. Heating the nitrile 3. With the alkyl-substituted hydrazine 4. In ethanol produces the 5-aminopyrazole 7. Presumably through the adduct 5. Should be larger than k. Fandr...
heterocyclist.com
Oldies-But-Goodies | The Heterocyclist
https://heterocyclist.com/category/oldies-but-goodies
A blog about heterocyclic chemistry. RSS for this section. August 6, 2015. Regioselective synthesis of 3- and 5-aminopyrazoles. Just a bit of sodium ethoxide does the trick …. Wouldn’t it be nice to be able to produce either the 3- or 5-aminopyrazole regioisomer in a selective fashion? From Boehringer Ingelheim is a most welcome arrival. Heating the nitrile 3. With the alkyl-substituted hydrazine 4. In ethanol produces the 5-aminopyrazole 7. Presumably through the adduct 5. Should be larger than k. Fandr...
heterocyclist.com
The Heterocyclist | A blog about heterocyclic chemistry | Page 2
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A blog about heterocyclic chemistry. October 21, 2012. How did this slip by the referees? Azomethine imines are not azomethine ylides. A recent paper by Xingwei Li and co-workers in Angewandte Chemie International Edition has some nice chemistry in it, but take a look at the title, “ Rhodium(III)-catalyzed oxidative C-H functionalization of azomethine ylides. 8221; One might expect to see some azomethine ylides, right? No, they are azomethine imines:. Edit: Here’s another paper from the same lab. Species...
heterocyclist.com
Drugs | The Heterocyclist
https://heterocyclist.com/category/drugs
A blog about heterocyclic chemistry. RSS for this section. February 4, 2013. Short Course: “Heterocyclic Chemistry – A Drug-Oriented Approach”. Interested in having a short course on Heterocyclic Chemistry at your company? In late 2011, I put together a new two-day short course entitled Heterocyclic Chemistry – A Drug-Oriented Approach. To present at companies. In a nutshell, it’s an intensive, preparatively-oriented. I keep it updated with lots of current chemistry. January 7, 2013. Here’s a process tha...
heterocyclist.com
On the regioselectivity of metal-catalyzed functionalizations of heteroaromatic C-H bonds | The Heterocyclist
https://heterocyclist.com/2012/07/11/on-the-regioselectivity-of-metal-catalyzed-functionalizations-of-heteroaromatic-ch-bonds
A blog about heterocyclic chemistry. July 11, 2012. In Reactions of Heterocycles. On the regioselectivity of metal-catalyzed functionalizations of heteroaromatic C-H bonds. A recent paper by Daniel Ess and co-workers at BYU ( Organic Letters. Moves us closer to that goal. Let’s say you’re in the drug discovery business and would like to snap a bunch of different arenes onto a core structure. Where will they go? Regioselectivity is often high (c.f. the example from Lapointe, Fagnou, and co-workers. Cited ...
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