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Northwest Regional Center of ExcellenceGenotype-phenotype associations in a nonmodel prokaryote. Measuring growth of tranpsoson mutants under a variety of nutrition and stress conditions helped define the biological functions of nonessential genes of Francisella novicida. Coordinated host responses during pyroptosis. Two conserved secretion pathways are shown to be initiated by caspase-1, lysosome exocytosis, and a parallel pathway resulting in cytokine release, and both enhance the antimicrobial nature of pyroptosis. April 7-9, 2013. E P (Pe...
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