oncofusion.com

OncoFusion

OncoFusion’s founders are endowed professors at the University of Michigan Medical School with many publications in leading journals. They also have successful experience. Starting up companies based on technologies originated from their labs. The entire management team is comprised of well-recognized leaders in the biopharmaceutical industry. Meet our leadership team. Targeting Cancer at the Gene Level. OncoFusion Therapeutics Reacquires Rights to BET Bromodomain Inhibitors. Is an oncology discovery and...

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OncoFusion | oncofusion.com Reviews

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OncoFusion’s founders are endowed professors at the University of Michigan Medical School with many publications in leading journals. They also have successful experience. Starting up companies based on technologies originated from their labs. The entire management team is comprised of well-recognized leaders in the biopharmaceutical industry. Meet our leadership team. Targeting Cancer at the Gene Level. OncoFusion Therapeutics Reacquires Rights to BET Bromodomain Inhibitors. Is an oncology discovery and...

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1 about us

2 people

3 the science

4 gene rearrangements

5 personalized therapy

6 pipeline

7 bet bromodomain inhibitors

8 erg inhibitors

9 ezh2 eed inhibitors

10 mmset/nsd2 inhibitors

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about us,people,the science,gene rearrangements,personalized therapy,pipeline,bet bromodomain inhibitors,erg inhibitors,ezh2 eed inhibitors,mmset/nsd2 inhibitors,news/publications,news/events,publications,oncofusion leadership,latest news,hile creative

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OncoFusion | oncofusion.com Reviews

https://oncofusion.com

OncoFusion’s founders are endowed professors at the University of Michigan Medical School with many publications in leading journals. They also have successful experience. Starting up companies based on technologies originated from their labs. The entire management team is comprised of well-recognized leaders in the biopharmaceutical industry. Meet our leadership team. Targeting Cancer at the Gene Level. OncoFusion Therapeutics Reacquires Rights to BET Bromodomain Inhibitors. Is an oncology discovery and...

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oncofusion.com

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News/Publications | OncoFusion

http://oncofusion.com/newspublications

Gene fusion has been shown to play a key role in the development of blood cancers and common solid tumors such as prostate, lung, colon and breast cancer. As leaders in the discovery and development of the next generation of personalized therapeutics for cancer patients, our work is frequently published in scientific journals and spotlighted by national media. Our most recently published research articles are available through the U.S. National Library of Medicine via PubMed.gov. Ann Arbor Website Design.

2

MMSET/NSD2 Inhibitors | OncoFusion

http://oncofusion.com/pipelines/mmsetnsd2-inhibitors

MMSET (NSD2 or WHSC1), like EZH2, is a histone methyltransferase. MMSET is found as a recurrent gene fusion with IgH in 20% of multiple myelomas (translocation t(4;14) . MMSET has also been shown to form a complex with BRD4 (see Bromodomain inhibitor. Studies by the founders, under revision in the journal. Suggest that EZH2 functions as an upstream activator of MMSET and that EZH2 and MMSET levels are tightly correlated in most human tumors. For partnership opportunities, please contact us.

3

Dr. Chinnaiyan in Wall Street Journal | OncoFusion

http://oncofusion.com/dr-chinnaiyan-in-wall-street-journal

Dr Chinnaiyan in Wall Street Journal. Dr Chinnaiyan in Wall Street Journal. Posted January 3rd, 2013. The Prostate Cancer Quandary-. Scientists may soon be able to answer the agonizing question facing men with prostate cancer: Does their cancer need treatment or can it be left alone? Several recent genetic discoveries could help doctors evaluate how aggressive a man’s prostate cancer is much earlier. Scientists at the University of Michigan. Based in Ann Arbor, Michigan, OncoFusion Therapeutics, Inc.

4

Gene Rearrangements | OncoFusion

http://oncofusion.com/the-science/gene-rearrangements

Cancer is a collection of diseases caused by a wide range of molecular lesions (or mutations). One important class of mutation, called gene fusions, is a common cause of many cancers. Fusion genes form during transcription by one of three mechanisms:. Gene deletion, or. Formation of the TMPRSS2:ERGa gene fusion. ( Science. 2005 Oct 28;310(5748):644-8.). By successfully identifying the molecular mechanism of gene rearrangements. We hope to provide personalized therapy. In the near future.

5

The Science | OncoFusion

http://oncofusion.com/the-science

One important class of mutation, called gene fusions, is a common cause of blood cancers. The prototypic example is the BCR-ABL gene fusion, characteristic of certain types of leukemia. Importantly, this finding led to the development of imatinib mesylate (Gleevec), which successfully targets the BCR-ABL gene fusion. Ninety-five percent of patients treated with this drug go into remission. Of a wide variety of cancer types. Based in Ann Arbor, Michigan, OncoFusion Therapeutics, Inc. Ann Arbor, MI 48109.

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OncoFusion’s founders are endowed professors at the University of Michigan Medical School with many publications in leading journals. They also have successful experience. Starting up companies based on technologies originated from their labs. The entire management team is comprised of well-recognized leaders in the biopharmaceutical industry. Meet our leadership team. Targeting Cancer at the Gene Level. OncoFusion Therapeutics Reacquires Rights to BET Bromodomain Inhibitors. Is an oncology discovery and...

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