otd-oncology.com

OTD : Oncology Therapeutic Development

Your partner in oncology. Independent consulting services in oncology early drug development. Collective experience managing over 60 Phase I-II oncology clinical trials. A boutique CRO focused solely on oncology and onco-hematology. Specialized in early development of single agent and combination anticancer regimens. Rapid and efficient development of promising new cancer treatments. Clinical/preclinical consulting for biotechs and VC groups to guide clinical development. Vázquez et al.

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OTD ONCOLOGY THERAPEUTIC DEVELOPMENT

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OTD : Oncology Therapeutic Development | otd-oncology.com Reviews

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Your partner in oncology. Independent consulting services in oncology early drug development. Collective experience managing over 60 Phase I-II oncology clinical trials. A boutique CRO focused solely on oncology and onco-hematology. Specialized in early development of single agent and combination anticancer regimens. Rapid and efficient development of promising new cancer treatments. Clinical/preclinical consulting for biotechs and VC groups to guide clinical development. Vázquez et al.

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1 about us

2 consulting

3 clinical

4 publications

5 oncology therapeutic development

6 missions

7 goals

8 publication

9 oncotarget

10 go to publication

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OTD : Oncology Therapeutic Development | otd-oncology.com Reviews

https://otd-oncology.com

Your partner in oncology. Independent consulting services in oncology early drug development. Collective experience managing over 60 Phase I-II oncology clinical trials. A boutique CRO focused solely on oncology and onco-hematology. Specialized in early development of single agent and combination anticancer regimens. Rapid and efficient development of promising new cancer treatments. Clinical/preclinical consulting for biotechs and VC groups to guide clinical development. Vázquez et al.

INTERNAL PAGES

otd-oncology.com

1

Techniques

http://www.otd-oncology.com/techniques-_r_5.html

Your partner in oncology. 92110 Clichy - FRANCE. Tel: 33 1 47 15 01 01. Fax: 33 1 45 19 06 59. In vitro models and biomarker analysis. ATCC oncology solid tumor and hematologic cell lines (panel of over 60 lines). In-house characterized models of paired epithelial/mesenchymal, drug-resistant/sensitive cell lines. Analyses of blood/sera, frozen biopsies, paraffin-embedded tissue. Murine subcutaneous xenograft and orthotopic models, housed in accredited facilities: first and second-line treatments after.

2

Consulting

http://www.otd-oncology.com/consulting-_r_8.html

Your partner in oncology. 92110 Clichy - FRANCE. Tel: 33 1 47 15 01 01. Fax: 33 1 45 19 06 59. OTD provides independent consulting services in oncology early drug development, from preclinical study design through clinical development programs. Review of proposed preclinical and clinical studies, resources, and timelines. Due diligence of pharmacology, toxicology, clinical, and CMC data, and regulatory affairs to guide preclinical and clinical development of novel anticancer drugs.

3

Clinical

http://www.otd-oncology.com/clinical-_r_10.html

Your partner in oncology. 92110 Clichy - FRANCE. Tel: 33 1 47 15 01 01. Fax: 33 1 45 19 06 59. The OTD team has collective experience managing over 50 Phase I-II oncology clinical trials, including several first-in-man molecules. Having collaborated with small biotech companies, mid-size and large pharmaceutical organizations, academic institutions and a wide selection of hospitals and clinics, our broad experience ensures an extensive international network. Leukemia (ALL, AML). Pharmacovigilance: databa...

4

Publications 2012-2015

http://www.otd-oncology.com/publications-_r_11.html

Your partner in oncology. 92110 Clichy - FRANCE. Tel: 33 1 47 15 01 01. Fax: 33 1 45 19 06 59. BET inhibitor OTX015 targets BRD2 and BRD4 and decreases c-MYC in acute leukemia cells. Coudé MM, Braun T, Berrou J, Dupont M, Bertrand S, Masse A, Raffoux E, Itzykson R, Delord M, Riveiro ME, Herait P, Baruchel A, Dombret H, Gardin C. Oncotarget. 2015 May 14. The BET Bromodomain Inhibitor OTX015 Affects Pathogenetic Pathways in Preclinical B-cell Tumor Models and Synergizes with Targeted Drugs. Astorgues-Xerri...

5

Publications 2000-2011

http://www.otd-oncology.com/publications-2000-2011-_r_6.html

Your partner in oncology. 92110 Clichy - FRANCE. Tel: 33 1 47 15 01 01. Fax: 33 1 45 19 06 59. Single agent and combination studies of pralatrexate and molecular correlates of sensitivity.Serova M, Bieche I, Sablin MP, Pronk GJ, Vidaud M, Cvitkovic E, Faivre S, Raymond E. Br J Cancer. 2011 Jan 18;104(2):272-80. Ghoul A, Serova M, Astorgues-Xerri L, Bieche I, Bousquet G, Varna M, Vidaud M, Phillips E, Weill S, Benhadji KA, Lokiec F, Cvitkovic E, Faivre S, Raymond E. Epithelial-to-mesenchymal transitio...

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OTD : Oncology Therapeutic Development

Your partner in oncology. Independent consulting services in oncology early drug development. Collective experience managing over 60 Phase I-II oncology clinical trials. A boutique CRO focused solely on oncology and onco-hematology. Specialized in early development of single agent and combination anticancer regimens. Rapid and efficient development of promising new cancer treatments. Clinical/preclinical consulting for biotechs and VC groups to guide clinical development. Vázquez et al.

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