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FAQs - IRX Inspire HNSCC
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IRX-2 & IRX-2 REGIMENS. IMMUNE SYSTEM IN HNSCC. HUMORAL VS CELLULAR IMMUNITY. WHY IS THE IRX-2 NEOADJUVANT REGIMEN ADMINISTERED LOCALLY? The IRX-2 Neoadjuvant Regimen is administered locally to promote uptake of endogenous tumor peptides by dendritic cells (DCs) and subsequent T-cell activation during the first treatment cycle. WHY IS THE IRX-2 NEOADJUVANT REGIMEN INITIATED PRIOR TO CURATIVE SURGERY? Accommodations will be provided or reimbursed for patients whose location requires them to be away from h...
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Inspire Videos - IRX Inspire HNSCC
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IRX-2 & IRX-2 REGIMENS. IMMUNE SYSTEM IN HNSCC. HUMORAL VS CELLULAR IMMUNITY.
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MOA - IRX Inspire HNSCC
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IRX-2 & IRX-2 REGIMENS. IMMUNE SYSTEM IN HNSCC. HUMORAL VS CELLULAR IMMUNITY. THE NEED FOR MULTIPLE MECHANISMS OF ACTION IN CANCER IMMUNOTHERAPY. Given the numerous cellular defects present in cancer, IRX believes that any single receptor cannot restore all cellular immune responses. Therefore:. Must be enlisted for an effective cellular immune response. There may be a benefit to a biologic with multiple active components versus a single cytokine. IRX-2 MECHANISMS OF ACTION. IRX-2 MECHANISMS OF ACTION.
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Humoral vs Cellular Immunity - IRX Inspire HNSCC
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IRX-2 & IRX-2 REGIMENS. IMMUNE SYSTEM IN HNSCC. HUMORAL VS CELLULAR IMMUNITY. HUMORAL VS CELLULAR IMMUNITY. The immune system can be broadly divided into a cellular and a humoral response. The cellular immune response relies on T cells, whereas the humoral immune response involves antibodies. Most cancer vaccines are directed at achieving a cellular immune response.
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Immunity in HNSCC - IRX Inspire HNSCC
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IRX-2 & IRX-2 REGIMENS. IMMUNE SYSTEM IN HNSCC. HUMORAL VS CELLULAR IMMUNITY. HUMORAL VS CELLULAR IMMUNITY. IN HEAD and NECK SQUAMOUS CELL CARCINOMA. Subjects with head and neck cancer are consistently immunocompromised. At the time of presentation. Hadden JW et al.
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Administration - IRX Inspire HNSCC
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IRX-2 & IRX-2 REGIMENS. IMMUNE SYSTEM IN HNSCC. HUMORAL VS CELLULAR IMMUNITY. ADMINISTRATION OF IRX-2 AS PART OF THE NEOADJUVANT REGIMEN. In head and neck squamous cell carcinoma, the IRX-2 biologic is injected into the mastoid region and drains into the lymphatic vessels, where physiologic quantities of IRX-2 restore the lymph node microenvironment and enable dendritic cells (DCs) to activate T cells against endogenous tumor peptides that have drained to the lymph node.
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Cellular Immunity - IRX Inspire HNSCC
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IRX-2 & IRX-2 REGIMENS. IMMUNE SYSTEM IN HNSCC. HUMORAL VS CELLULAR IMMUNITY. HUMORAL VS CELLULAR IMMUNITY. In a healthy immune system, the cellular immune response works to clear foreign pathogens every day. Immature dendritic cells (DCs) ingest disease antigens, then migrate to lymph nodes where they mature. The mature DCs activate naïve T cells and create cytotoxic T cells. The cytotoxic T cells proliferate, enter the circulation, search out, and kill the antigenic target.
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Regimen Overview - IRX Inspire HNSCC
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Immune System Overview - IRX Inspire HNSCC
http://hcp.inspirehnc.com/immune-system-overview
IRX-2 & IRX-2 REGIMENS. IMMUNE SYSTEM IN HNSCC. HUMORAL VS CELLULAR IMMUNITY. HUMORAL VS CELLULAR IMMUNITY. IN HEAD and NECK SQUAMOUS CELL CARCINOMA. The immune system is a mechanism by which an organism differentiates between self (its own tissues) and non-self (everything else) and protects against non-self. Cancer cells originate as self, but as they convert from normal cells into cancer cells, they develop new and different proteins or peptides on their cell surface.