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Rob Beagrie / Molecular Biologist / Python Programmer

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Rob Beagrie / Molecular Biologist / Python Programmer | rob.beagrie.com Reviews

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Rob Beagrie's Blog

Enhancer Journal Club: Enhancer runaway and the evolution of diploid gene expression. I came across this very interesting theoretical paper about enhancer evolution a couple of months ago. And thought it was worth a little discussion. The paper comes from Frederic Fyon and others at the CNRS in Montpellier. The original paper can be found at PLOS Genetics, and it's well worth a read. Stronger enhancer homozygote (d). And enhancer locus heterozygotes (b). Or with the viable gene allele (c). Fyon, F. e...

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Resume

http://rob.beagrie.com/cv

Blog: blog.rob.beagrie.com. I'm a Postdoctoral researcher working in Ana Pombo's lab at the MDC in Berlin (pombolab.wordpress.com). I work on both wet-lab and bioinformatics projects, with a major interest in cis-regulatory elements in mammalian genomes. I'm especially fascinated by the regulation of gene expression by 3D chromatin folding, and the mechanisms of enhancer action. Berlin Institute for Medical Systems Biology. MRC Funded PhD Studentship. MRC Clinical Sciences Centre. 1 week placement in the...

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FOS - Rob Beagrie's Blog

https://blog.rob.beagrie.com/tag/fos.html

Wed 01 October 2014. Enhancer Journal Club: Genome-wide identification and characterization of functional neuronal activity dependent enhancers. I noticed a nice paper this week in Nature Neuroscience from Michael Greenberg's lab at Harvard Medical School. The paper discusses the identification of enhancers in neurons which are activated (or deactivated) when those neurons are stimulated by membrane de-polarization. The original paper can be found at: http:/ www.nature. Page 1 / 1.

blog.rob.beagrie.com blog.rob.beagrie.com

Neurons - Rob Beagrie's Blog

https://blog.rob.beagrie.com/tag/neurons.html

Wed 01 October 2014. Enhancer Journal Club: Genome-wide identification and characterization of functional neuronal activity dependent enhancers. I noticed a nice paper this week in Nature Neuroscience from Michael Greenberg's lab at Harvard Medical School. The paper discusses the identification of enhancers in neurons which are activated (or deactivated) when those neurons are stimulated by membrane de-polarization. The original paper can be found at: http:/ www.nature. Page 1 / 1.

blog.rob.beagrie.com blog.rob.beagrie.com

Enhancer Journal Club: Genome-wide identification and characterization of functional neuronal activity–dependent enhancers - Rob Beagrie's Blog

https://blog.rob.beagrie.com/2014/10/01/enhancer-journal-club-genome-wide-characterization-of-neuronal-activity-dependent-enhancers

Enhancer Journal Club: Genome-wide identification and characterization of functional neuronal activity dependent enhancers. Wed 01 October 2014. The abstract is as follows:. Depolarization. In contrast, no putative enhancers with constant or decreased H3K27Ac after KCl treatment showed higher activity in the luciferase assay following the same treatment. Rob Beagrie - Proudly powered by pelican. Theme inspired by pelican-sober.

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GFI1 - Rob Beagrie's Blog

https://blog.rob.beagrie.com/tag/gfi1.html

Wed 07 October 2015. Enhancer Journal Club: Enhancer hijacking activates GFI1 family oncogenes in medulloblastoma. I read a neat little paper in Nature just before Christmas about enhancer hijacking, which I think is a particularly interesting topic. The original paper can be found at: http:/ www.nature.com/nature/journal/v511/n7510/full/nature13379.html. The abstract is as follows:. Medulloblastoma is a highly malignant. Page 1 / 1. Rob Beagrie - Proudly powered by pelican.

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Enhancers - Rob Beagrie's Blog

https://blog.rob.beagrie.com/tag/enhancers.html

Tue 28 February 2017. Enhancer Journal Club: Enhancers and super-enhancers have an equivalent regulatory role in embryonic stem cells through regulation of single or multiple genes. I've been thinking a lot about super-enhancers recently and I found this paper. From Jennifer Mitchell's lab very interesting, especially as whether and how super-enhancers are distinct from "normal" enhancers has been generating a lot of discussion in the enhancer/gene-regulation literature recently. Sun 28 February 2016.

blog.rob.beagrie.com blog.rob.beagrie.com

Enhancer Journal Club: Functional annotation of native enhancers with a Cas9-histone demethylase fusion - Rob Beagrie's Blog

http://blog.rob.beagrie.com/2015/11/05/enhancer-journal-club-functional-annotation-of-native-enhancers

Enhancer Journal Club: Functional annotation of native enhancers with a Cas9-histone demethylase fusion. Thu 05 November 2015. I really enjoyed Eric Mendenhall's 2013 paper in Nature Biotechnology. Where he was able to target LSD1 histone demethylase activity to endogenous enhancers using TALE fusion proteins (read my thoughts on that paper here. So I was very interested to see a similar approach published earlier this year in Nature Methods. Luciferase activity either of the ODE or of enhancer 1 (Enh1)&...

blog.rob.beagrie.com blog.rob.beagrie.com

Enhancer Journal Club: Enhancer runaway and the evolution of diploid gene expression - Rob Beagrie's Blog

http://blog.rob.beagrie.com/2016/02/28/enhancer-journal-club-enhancer-runaway-and-gene-expression-evolution

Enhancer Journal Club: Enhancer runaway and the evolution of diploid gene expression. Sun 28 February 2016. I came across this very interesting theoretical paper about enhancer evolution a couple of months ago. And thought it was worth a little discussion. The paper comes from Frederic Fyon and others at the CNRS in Montpellier. The original paper can be found at PLOS Genetics, and it's well worth a read. Stronger enhancer homozygote (d). And enhancer locus heterozygotes (b). Fyon, F. et al., Enh...Akali...

blog.rob.beagrie.com blog.rob.beagrie.com

evolution - Rob Beagrie's Blog

https://blog.rob.beagrie.com/tag/evolution.html

Sun 28 February 2016. Enhancer Journal Club: Enhancer runaway and the evolution of diploid gene expression. I came across this very interesting theoretical paper about enhancer evolution a couple of months ago. And thought it was worth a little discussion. The paper comes from Frederic Fyon and others at the CNRS in Montpellier. The original paper can be found at PLOS Genetics, and it's well. Page 1 / 1. Rob Beagrie - Proudly powered by pelican. Theme inspired by pelican-sober.

blog.rob.beagrie.com blog.rob.beagrie.com

gene expression - Rob Beagrie's Blog

https://blog.rob.beagrie.com/tag/gene-expression.html

Post tagged: gene expression. Sun 28 February 2016. Enhancer Journal Club: Enhancer runaway and the evolution of diploid gene expression. I came across this very interesting theoretical paper about enhancer evolution a couple of months ago. And thought it was worth a little discussion. The paper comes from Frederic Fyon and others at the CNRS in Montpellier. The original paper can be found at PLOS Genetics, and it's well. Thu 05 November 2015. Mon 25 November 2013. Thu 31 October 2013. Moving away from e...

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