settrend.cebio.org

Welcome | SEtTReND

Bull; Identify the histone modifying enzymes (HME) encoded in the Schistosoma mansoni genome using bioinformatics. Bull; Clone and produce recombinant proteins. Bull; Validate these enzymes as targets. Bull; Test generic inhibitors of HMEs for their effects on parasites in culture. Bull; Use computational approaches to model the proteins and identify potential specific inhibitors. Bull; Use high-throughput screens and subsequent synthetic optimization to identify specific inhibitors of selected HMEs.

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Bull; Identify the histone modifying enzymes (HME) encoded in the Schistosoma mansoni genome using bioinformatics. Bull; Clone and produce recombinant proteins. Bull; Validate these enzymes as targets. Bull; Test generic inhibitors of HMEs for their effects on parasites in culture. Bull; Use computational approaches to model the proteins and identify potential specific inhibitors. Bull; Use high-throughput screens and subsequent synthetic optimization to identify specific inhibitors of selected HMEs.

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7 presentations

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9 welcome

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Welcome | SEtTReND | settrend.cebio.org Reviews

https://settrend.cebio.org

Bull; Identify the histone modifying enzymes (HME) encoded in the Schistosoma mansoni genome using bioinformatics. Bull; Clone and produce recombinant proteins. Bull; Validate these enzymes as targets. Bull; Test generic inhibitors of HMEs for their effects on parasites in culture. Bull; Use computational approaches to model the proteins and identify potential specific inhibitors. Bull; Use high-throughput screens and subsequent synthetic optimization to identify specific inhibitors of selected HMEs.

INTERNAL PAGES

settrend.cebio.org

1

Funding | SEtTReND

http://settrend.cebio.org/content/2011/01/26/funding

SEtTReND is funded by the European Comission Seventh Framework Programme (FP7). The Seventh Framework Programme (FP7) of the European Commission. Is designed to support a wide range of participants: from universities, through public authorities to small enterprises and researchers in developing countries. Bull; Private companies – such as small and medium sized enterprises (SMEs), private research institutes or other industrial participants. Agriculture and food supply. Biology and medicine (Health).

2

Project Members | SEtTReND

http://settrend.cebio.org/content/2009/11/05/project-member

Raymond J. Pierce. Inserm U 547 - Institut Pasteur de Lille Lille France. Wwwpasteur-lille.fr/fr/recherche/unites/u547 capron fr.html. Our focus is the characterization of the epigenetic mechanisms involved in the control of gene transcription during the development and differentiation of the flatworm parasite, Schistosoma mansoni. Eric M. Verdin, M.D. Gladstone Institute of Virology and Immunology San Francisco United States. FIOCRUZ - Institute Rene Rachou Belo Horizonte Brazil. Our main research is fo...

3

Publications | SEtTReND

http://settrend.cebio.org/content/2012/11/26/publications

Inhibitors of the NAD -Dependent Protein Desuccinylase and Demalonylase Sirt5. B Maurer, T. Rumpf, M. Scharfe, D. A. Stolfa, M. L. Schmitt, W. He, E. Verdin, W. Sippl, M. Jung; ACS Med. Chem. Lett. (2012) in press. The discovery of novel and highly selective 10,11-dihydro-5H-dibenz[b,f]azepine SIRT2 inhibitors. Pierce RJ, Dubois-Abdesselem F, Lancelot J, Andrade L, Oliveira G. Targeting Schistosome histone modifying enzymes for drug development. Curr Pharm Des. 2012. 18(24):3567-3578. Pierce, R.J&#46...

4

Post and News | SEtTReND

http://settrend.cebio.org/content/2011/06/20/post-and-news

B Bice - Braziian projects bunded by the FP7 Program. FRIAS interdisciplinary research group awarded to W. Sippl, M. Jung and O. Einsle (Freiburg). 02/06/2010 - SETtReND in the news at FIOCRUZ. 09/05/2010 - Young Researcher - Manfred Jung. IUPAC - A survey of research into new drugs for neglected diseases in Latin America. To raise awareness of neglected diseases in Latin America and encourage researchers to select them as subjects for new drug discover. Link to the web page.

5

Presentations | SEtTReND

http://settrend.cebio.org/content/2012/11/26/presentations

Oliveira, G. Mining the. Genome for new drug targets. Tercero Congresso Argentino de Bioinformatica e Biologia Computacional. Universidad Nacional de Entre Rios, Oro Verde, Argentina. 26-28 september 2012. Oliveira, G. Mining the. Genome for new drug targets. International Conference on Tropical Medicine and Malaria. Royal Tulip Hotel, Rio de Janeiro, 23-27 september 2012. Histone deacetylase inhibitors in. Schistosome histone modifying enzymes as drug targets. FRIAS workshop on medical epigenetics a...

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epakolpingcoc.blogspot.com

"Blog do EPA Kolping COC": Janeiro 2012

http://epakolpingcoc.blogspot.com/2012_01_01_archive.html

Blog do EPA Kolping COC". EPA-grupo formado por pré-vestibulandos e alunos do Kolping,seu principal objetivo é ajudar a todos que tenham dúvidas e solucioná-las através dos mesmos para o exito final:aprovação! Terça-feira, 17 de janeiro de 2012. Grupo internacional decifra genoma do ‘Schistossoma haematobium’, um dos três maiores causadores da esquistossomose. O objetivo agora é a criação de medicamentos capazes de combater todos os parasitas da doença ao mesmo tempo. Por: Ana Carolina Correia. E tecnolo...

cebio.org

Colaboradores | CEBio - Centro de Excelência em Bioinformática de Minas Gerais

http://www.cebio.org/colaboradores

Política de Segurança da Informação (PSI). No upcoming events available. Rede Genoma de Minas Gerais. INCT Doenças Tropicais. Universidade da Georgia - Center for Tropical and Emerging Global Diseases. Museu de História Natural de Londres. Universidade Federal de Minas Geraias. Departamento de Biologia Geral, Eduardo Tarazona, Maria Raquel Santos Carvalho. EMBRAPA Gado de Leite. Marcos Vinícius Barbosa da Silva, Wagner Arbex. Polo de Excelência em Genética Bovina.

cebio.org

Projetos em andamento | CEBio - Centro de Excelência em Bioinformática de Minas Gerais

http://www.cebio.org/projetos-em-andamento

Política de Segurança da Informação (PSI). No upcoming events available. Centro de Genômica Vale-FIOCRUZ - Genômica para soluções e inovações biotecnológicas. Centro de Genômica Vale-FIOCRUZ - Genômica para soluções e inovações biotecnológicas. VALE S. A./FIOCRUZ. Infectious disease genomics and bioinformatics training in Brazil. Infectious disease genomics and bioinformatics training in Brazil. Centro de Excelência em Bioinformática. Centro de Excelência em Bioinformática. RGMG pretende aprofundar no tr...

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settrend.cebio.org

Welcome | SEtTReND

Bull; Identify the histone modifying enzymes (HME) encoded in the Schistosoma mansoni genome using bioinformatics. Bull; Clone and produce recombinant proteins. Bull; Validate these enzymes as targets. Bull; Test generic inhibitors of HMEs for their effects on parasites in culture. Bull; Use computational approaches to model the proteins and identify potential specific inhibitors. Bull; Use high-throughput screens and subsequent synthetic optimization to identify specific inhibitors of selected HMEs.

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