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What is Hydractinia? - The Nicotra Lab

http://www.nicotralab.org/what-is-hydractinia.html

We study allorecognition in. The Allorecognition Complex (ARC). Using inbred lines of. We and our collaborators have demonstrated that allorecognition is controlled by two linked genes, called. Alleles in a single population! And sequence variation in the extracellular domain predicts allorecognition phenotypes. No unlinked allorecognition loci have been detected in systematic searches of three wild-type genetic backgrounds. Schematic of a Hydractinia. Rejection between two Hydractinia.

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Allorecognition & Transplantation - The Nicotra Lab

http://www.nicotralab.org/allorecognition--transplantation.html

If invertebrate allorecognition systems are homologous to elements of mammalian immune systems, it could lead to the identification of new or previously unappreciated signaling pathways involved in the graft rejection. Our ongoing work to define the allorecognition signaling pathway in. Is generating data to address exactly this issue. As members of the Thomas E. Starzl Transplantation Institute. At the University of Pittsburgh. We are uniquely positioned to translate findings from.

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OUTREACH - The Nicotra Lab

http://www.nicotralab.org/outreach.html

Pitt Mobile Science Lab. In collaboration with the staff of the Pitt Mobile Science Lab. We are developing an educational module to teach high school students basic molecular biology techniques in the context of. Allorecognition. Students will use PCR and gel electrophoresis to predict the genotypes of hydractinia colonies, and then test their predictions by observing those same colonies interact in real time. This module will be incorporated into the curriculum of the Mobile Science Lab, a self-...This ...

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Current Projects - The Nicotra Lab

http://www.nicotralab.org/current-projects.html

The biophysical and structural basis of allorecognition specificity. How do alr1 and alr2, by themselves, distinguish self from non-self? The allorecognition signaling pathway. To answer this question, one must first define the allorecognition signal transduction pathway. We hypothesize that the cytoplasmic tails of alr1 and alr2 initiate allorecognition responses because they are relatively large and bear a number of potential phosphorylation sites. Our current work focuses on determining whethe...Predi...

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PUBLICATIONS - The Nicotra Lab

http://www.nicotralab.org/publications.html

Karadge UB, Gosto M, and Nicotra ML. Allorecognition mediated by homophilic protein-protein interactions in an invertebrate". Houser BL, Tilburgs T, Hill J, Nicotra ML. Strominger JL. 2011. “Two unique human decidual macrophage populations.”. Rosengarten RD and Nicotra ML. 2010 "Model systems of invertebrate allorecognition.". Rosa SFP, Powell AE, Rosengarten RD,. Moreno MA, Grimwood J, Lakkis FG, Dellaporta SL, Buss LW. 2010. “. Resides in an Immunoglobulin Superfamily-like gene complex.”. THOMAS E....

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The Nicotra Lab - NEWS

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Graduate student Aidan Huene joins the lab! We are happy to welcome Aidan Huene into the lab! Aidan is a first year graduate student in the ISB program. She will be working out the mechanisms by which the Alr1/2 proteins are able to engage in isoform-specific homophilic binding. and probably some other exciting things too! Bringin' hydroids to the people. Drake Ma showing Hydractinia to a young football fan. Our second Pitt Mobile Science Lab tailgate program was a success! Can't wait for next year!

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What is Allorecognition? - The Nicotra Lab

http://www.nicotralab.org/what-is-allorecognition.html

Colonies that have grown into contact and fused. Incompatible colonies of the bryozoan, Calpensia nobilis. Photo credit: Wolfgang Seifarth. Fusing colonies of the ascidian, Botryllus schlosseri. Photo credit: Lovell and Libby Langstroth California Academy of Sciences. THOMAS E. STARZL TRANSPLANTATION INSTITUTE. 2015 Matthew Nicotra Updated February 12, 2016. This site was created and is maintained through support from the National Science Foundation.

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JOIN - The Nicotra Lab

http://www.nicotralab.org/join.html

If you are interested in joining my lab as a postdoc, please drop me an email! If you are interested in joining my lab as a graduate student, I strongly suggest you contact me prior to applying. Graduate students in my lab must be accepted into one of two graduate programs:. The Interdisciplinary Biomedical Graduate Program. In the University of Pittsburgh School of Medicine, where I am a faculty member in the. Cell Biology and Molecular Physiology Program. The Integrative Systems Biology Program.

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CALENDAR - The Nicotra Lab

http://www.nicotralab.org/calendar.html

To subscribe to this calendar use one of the URLs below:. ICal: https:/ www.google.com/calendar/ical/nicotralab%40gmail.com/public/basic.ics. HTML: https:/ www.google.com/calendar/embed? XML: https:/ www.google.com/calendar/feeds/nicotralab%40gmail.com/public/basic. THOMAS E. STARZL TRANSPLANTATION INSTITUTE. 2015 Matthew Nicotra Updated February 12, 2016. This site was created and is maintained through support from the National Science Foundation.