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Rationale | Quality and safety of food in relation to colorectal cancer predisposition
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Quality and safety of food in relation to colorectal cancer predisposition. Biomarkers of DNA integrity and stability. Sporadic Colorectal Cancer (CRC) is representing the crutial health issue as it is associated with the highest mortality in Europe. It is estimated that about one third of all cancers may be caused by an inappropriate balance of food components. Biomarkers of DNA integrity and stability. Department of the Molecular Biology of Cancer, Institute of Experimental Medicine, ASCR, v.v.i.
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Meetings | Quality and safety of food in relation to colorectal cancer predisposition
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Quality and safety of food in relation to colorectal cancer predisposition. Biomarkers of DNA integrity and stability. Third Norwegian-Czech Project meeting, Oslo, Norway. Third meeting of Czech and Norwegian partners hold on 14-15th of September, 2010. Second Norwegian-Czech Project meeting, Zebrak, Czech Republic. Second meeting of Czech and Norwegian partners hold on 27-28th of May, 2010. First Norwegian-Czech Project meeting, Oslo, Norway. Tvorba www stránek. Ivan Voříšek.
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Partners | Quality and safety of food in relation to colorectal cancer predisposition
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Quality and safety of food in relation to colorectal cancer predisposition. Biomarkers of DNA integrity and stability. Czech-Norwegian collaboration between institutes:. Institute of Experimental Medicine. Academy of Sciences,. Praque, Czech Republic, http:/ www.iem.cas.cz/. Dr Pavel Vodička, PhD. Dr Pavel Vodička, PhD. Dr Alesio Naccarati, PhD. Dr Ludmila Vodičková, PhD. Msc Jana Slyšková. Faculty of Military Health Sciences. University of Defence,. Hradec Kralove, Czech Republic ,. Norway, http:/ www&#...
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Colorectal cancer | Quality and safety of food in relation to colorectal cancer predisposition
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Quality and safety of food in relation to colorectal cancer predisposition. Biomarkers of DNA integrity and stability. The development of CRC is characterized by a sequence of events during which normal colonic epithelium gradually transforms into carcinoma tissue, in most cases via the development of colorectal adenomas, also known as polyps. Reference: Tanaka et al., 2009. Biomarkers of DNA integrity and stability. Tvorba www stránek. Ivan Voříšek.
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Publications | Quality and safety of food in relation to colorectal cancer predisposition
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Quality and safety of food in relation to colorectal cancer predisposition. Biomarkers of DNA integrity and stability. The first manuscript DNA damage, DNA repair rates and mRNA expression levels of cell cycle genes (TP53, p21CDKN1A, BCL2 and BAX) with respect to occupational exposur to styrene has been published in Carcinogenesis. 32, 74-79, 2011. Http:/ carcin.oxfordjournals.org/content/early/2010/10/21/carcin.bgq213.abstract. On 27th january 2011. Tvorba www stránek. Ivan Voříšek.
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Project in progress | Quality and safety of food in relation to colorectal cancer predisposition
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Quality and safety of food in relation to colorectal cancer predisposition. Biomarkers of DNA integrity and stability. Table of tasks distributed for corresponding time period . European Environmental Mutagen Society - Oslo 2010. First Norwegian-Czech Project meeting, Oslo, Norway. Second Norwegian-Czech Project meeting, Zebrak, Czech Republic. Third Norwegian-Czech Project meeting, Oslo, Norway. Department of the Molecular Biology of Cancer, Institute of Experimental Medicine, ASCR, v.v.i.
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Project | Quality and safety of food in relation to colorectal cancer predisposition
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Quality and safety of food in relation to colorectal cancer predisposition. Biomarkers of DNA integrity and stability. This project was funded by Research Support Fund, http:/ eeagrants.org/. Starting date of the project: 1.8.2009. Closing date of the project: 31.12.2010. Duration of the project: 17 months. Focus area of research: 4.3 Research and Development in food safety and quality. Type of R&D: Experimental development. In the frame of this project we will investigate. Department of the Molecular Bi...
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Aims | Quality and safety of food in relation to colorectal cancer predisposition
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Quality and safety of food in relation to colorectal cancer predisposition. Biomarkers of DNA integrity and stability. We intend to investigate:. Induced by alkylating agents and oxidative species in peripheral blood mononuclear cells (PBMC);. Functional aspects of DNA repair capacity. Measured in PBMC as individual DNA represent an important measure of individual susceptibility and is considered to be a relevant player in CRC pathogenesis;. The influence of functional polymorphisms in DNA repair genes.
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Objectives and Indicators | Quality and safety of food in relation to colorectal cancer predisposition
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Quality and safety of food in relation to colorectal cancer predisposition. Biomarkers of DNA integrity and stability. Our specific aims are:. To find out, whether there is a relationship between particular dietary intake, health status and individual level of DNA damage and DNA repair capacity. To identify those food compounds associated with the strongest possible impact on health status. To develop a method for determining DNA repair capacities in solid tumour tissues in order to measure this importan...
