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Calpain Research Portal: Calpain Structure and Nomenclature

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Calpain Research Portal: Calpain Structure and Nomenclature | calpain.net Reviews

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Calpain Research Portal: Calpain Structure and Nomenclature

http://www.calpain.net/3dstructure/index.html

The 3D structure of a portion of calpain (the PEF(L) domain of CAPNS1) was first solved in 1997 ( Blanchard et al., 1997. Lin et al., 1997. In 1999 and 2000, whole 3D structures of the inactive forms (Ca. Unbound) of rat and human m-calpain[CAPN2/S1], respectively, were determined ( Hosfield et al., 1999. Strobl et al., 2000. Later, 3D structures of the protease ( CysPc. Domains of CAPN1, 2, and 9 in the presence of Ca. Moldoveanu et al., 2002. Moldoveanu et al., 2003. Moldoveanu et al., 2008. Calpain-li...

2

Calpain Research Portal: Calpain Structure and Nomenclature

http://www.calpain.net/reagents/index.html

Reagents / general site. TRIPLE POINT BIOLOGICS, Inc.

3

Structure and nomenclature / Calpain Research Portal: Calpain Structure and Nomenclature

http://www.calpain.net/structure/index.html

The study of calpains has a long history, starting in 1964 when Gordon Guroff first discovered calpain in the brain. Since then, many researchers have given numerous names to a variety of calpain molecules as well as their component domains. Thus, a common nomenclature for the calpains and their domains needs to be established. And Fig. 1.

4

Calpain Research Portal: Calpain Structure and Nomenclature

http://www.calpain.net/links/index.html

Calpain Pages at Univ. of Arizona. Symmetry alignment of EF-hand. The EF-Hand Calcium-Binding Proteins Data Library. Handbook of Proteolytic Enzymes, Third Edition (Elsevier). Leiden Muscular Dystrophy Pages. Center for Human and Clinical Genetics,Leiden University Medical Center). IPS (International Proteolysis Society).

5

Calpain Research Portal: Calpain Structure and Nomenclature

http://www.calpain.net/meetings/index.html

2016 FASEB Summer Research Conference (SRC). The Biology of Calpains in Health and Disease". At Big Sky Resort, Montana, USA; July 17-22, 2016. Chairs: Peter Greer, Kevin K.W. Wang, and Athar Chishti. 2013 FASEB Summer Research Conference (SRC). Calpains Function in Biology and Disease. At Saxtons River, Vermont, USA; July 21-26, 2013. Chairs: James Geddes, and Peter Greer. 2010 FASEB Summer Research Conference (SRC). The Biology of Calpains in Health and Disease. Biology of Calpains in Health and Disease.

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Calpain Research Portal: Calpain Structure and Nomenclature

Welcome to Calpain Research Portal! Calpain is an intracellular Ca. Dependent cysteine protease (EC 3.4.22.17; Clan CA, family C02). Calpain has limited proteolytic activity; it transforms or modulates the structure and/or activity of its substrates. It is, therefore, referred to as a modulator protease . Calpains are found in almost all eukaryotes and a few eubacteria, but not in archaebacteria. In the human genome, 15 genes (. Encode a calpain-like protease ( CysPc. We very much welcome your comments!

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CaMPDB : Calpain for Modulatory Proteolysis

Welcome to CaMPDB, Calpain for Modulatory Proteolysis Database. Try CalCleave, our online cleavage site predictor ». 1496 calpain sequences ( CL. 2018 calpain substrate sequences. 104 curated sequences ( SB. 1914 expanded sequences ( XSB. 209 calpastatin sequences ( CT. Total : 3723 sequences ≫ More. D duVerle, I Takigawa, Y Ono, H Sorimachi, H Mamitsuka, CaMPDB: a Resource for Calpain and Modulatory Proteolysis, Genome Informatics. 22: 202-214 (2009) [ pubmed. Last modified: 2017-06-15 12:53:35 0900.

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