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New Reactions | Reviewing new organic methodology, one paper at a time… | newreactions.wordpress.com Reviews
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Reviewing new organic methodology, one paper at a time...
newreactions.wordpress.com
March | 2012 | New Reactions
https://newreactions.wordpress.com/2012/03
The Latest from the Literature. Life as a Reaction Junkie. On the Humorous Side…. Random but awesome…. Special new post coming soon…keep an eye on http:/ www.brsmblog.com😛. UPDATE New guest post on BRSM Blog: Unnatural Products 4: Tetrahedrane. March 31, 2012. Comments: Leave a comment. What’s that smell? Synthesis of Sulfur-Containing Heterocycles through Oxidative Carbon Hydrogen Bond Functionalization Cui, Y. Floreancig, P. E. ASAP March 15, 2012. This week’s article comes from Floreancig group.
June | 2012 | New Reactions
https://newreactions.wordpress.com/2012/06
The Latest from the Literature. Life as a Reaction Junkie. On the Humorous Side…. Random but awesome…. And suddenly fluorine…all of it! Methyl 2,2-Difluoro-2-(fluorosulfonyl)acetate, a Difluorocarbene Reagent with Reactivity Comparable to That of Trimethylsilyl 2,2-Difluoro-2-(fluorosulfonyl)acetate (TFDA) Eusterwiemann, S. Martinez, H. Dolbier, W. R., Jr. ASAP May 21, 2012. Angew Chem. Int. Ed. Early View May 22, 2012. 2 2] Cyclobutanone Synthesis. So go check them out! And saw some excellent presentati...
April | 2011 | New Reactions
https://newreactions.wordpress.com/2011/04
The Latest from the Literature. Life as a Reaction Junkie. On the Humorous Side…. Random but awesome…. So if you’ve been following me for a while you know that I recently published an article. In organic letters regarding the synthesis of a trifluoromethyl derivative of bicyclobutane. Apparently the ACS liked it enough to feature it on its “Noteworthy Chemistry” :. So go check it out! April 26, 2011. Comments: Leave a comment. Won’t you be my neighbor? Sakthivel, K. Srinivasan, K. Eur J Org. Chem. They f...
November | 2011 | New Reactions
https://newreactions.wordpress.com/2011/11
The Latest from the Literature. Life as a Reaction Junkie. On the Humorous Side…. Random but awesome…. Proline: Not Your Typical Amino Acid? Our paper with Dr. Fenteany’s group did not get into. But we just submitted to. In other news, I wanted to extend a warm congratulations to my friend Ryan Carris on his most recent publication. In JACS no less)! Ryan is a graduate student in the Johnson Lab. Now it’s time for something I haven’t done in ages, a review! European Journal of Organic Chemistry. The arti...
December | 2011 | New Reactions
https://newreactions.wordpress.com/2011/12
The Latest from the Literature. Life as a Reaction Junkie. On the Humorous Side…. Random but awesome…. Eddy, N. A. Kelly, C. B. Mercadante, M. A. Leadbeater, N. E. Fenteany G. Access to Dienophilic Ene-Triketone Synthons by Oxidation of Diketones with an Oxoammonium Salt. ASAP December 29, 2011. On a large scale, this meant greater than 60 grams of salt. So we became experts at preparing Bobbitt’s salt (which, as I’ve said, is very easy). Ratios. The sheer complexity of the molecules were generating ...
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sussexdrugdiscovery.wordpress.com
October | 2014 | Sussex Drug Discovery Centre
https://sussexdrugdiscovery.wordpress.com/2014/10
Sussex Drug Discovery Centre. Medicinal, Chemistry and Biochemistry blog from the Sussex Drug Discovery Centre. Skip to primary content. Skip to secondary content. Sussex Drug Discovery Centre. Monthly Archives: October 2014. Alzheimer’s in a dish’ – A 3D cell culture model of Alzheimer’s disease. October 20, 2014. This month a group in the US have published an elegant study. Amyloid-β deposits in control (ReN-G) and FAD ReN (ReN-mGAP). This important work has not only provided experimental evidence supp...
sussexdrugdiscovery.wordpress.com
November | 2014 | Sussex Drug Discovery Centre
https://sussexdrugdiscovery.wordpress.com/2014/11
Sussex Drug Discovery Centre. Medicinal, Chemistry and Biochemistry blog from the Sussex Drug Discovery Centre. Skip to primary content. Skip to secondary content. Sussex Drug Discovery Centre. Monthly Archives: November 2014. In Silico Prediction of Off Target Activities of Chemical Probes. A recent publication highlights the importance of assessing broad selectivity and describes an in silico approach capable of predicting off target liabilities ( Antolín and Mestres, ACS Chemical Biology 2014, ahead o...
sussexdrugdiscovery.wordpress.com
September | 2014 | Sussex Drug Discovery Centre
https://sussexdrugdiscovery.wordpress.com/2014/09
Sussex Drug Discovery Centre. Medicinal, Chemistry and Biochemistry blog from the Sussex Drug Discovery Centre. Skip to primary content. Skip to secondary content. Sussex Drug Discovery Centre. Monthly Archives: September 2014. Can we predict compound precipitation in DMSO stocks? September 28, 2014. To determine if a physicochemical property could be identified as a correlating factor for increased precipitation rate in the Tox set compared to the fragment set , the MW, clogP, fsp3 (fraction of sp3 carb...
sussexdrugdiscovery.wordpress.com
February | 2015 | Sussex Drug Discovery Centre
https://sussexdrugdiscovery.wordpress.com/2015/02
Sussex Drug Discovery Centre. Medicinal, Chemistry and Biochemistry blog from the Sussex Drug Discovery Centre. Skip to primary content. Skip to secondary content. Sussex Drug Discovery Centre. Monthly Archives: February 2015. Toward a future of truly personalized cancer therapy. February 12, 2015. Targeted cancer therapies have produced substantial clinical results in the last decade, but most tumours eventually develop resistance to these drugs. Benes, Engelman and colleagues have recently described in.
sussexdrugdiscovery.wordpress.com
pbeswick | Sussex Drug Discovery Centre
https://sussexdrugdiscovery.wordpress.com/author/pbeswick
Sussex Drug Discovery Centre. Medicinal, Chemistry and Biochemistry blog from the Sussex Drug Discovery Centre. Skip to primary content. Skip to secondary content. Sussex Drug Discovery Centre. Toward a future of truly personalized cancer therapy. February 12, 2015. Targeted cancer therapies have produced substantial clinical results in the last decade, but most tumours eventually develop resistance to these drugs. Benes, Engelman and colleagues have recently described in. Or anaplastic lymphoma kinase (.
sussexdrugdiscovery.wordpress.com
December | 2014 | Sussex Drug Discovery Centre
https://sussexdrugdiscovery.wordpress.com/2014/12
Sussex Drug Discovery Centre. Medicinal, Chemistry and Biochemistry blog from the Sussex Drug Discovery Centre. Skip to primary content. Skip to secondary content. Sussex Drug Discovery Centre. Monthly Archives: December 2014. Highlights from Society of Medicines Research Meeting 4th December 2014. December 16, 2014. The Society for Medicines Research was hosting the Recent Disclosures of Clinical Candidates meeting on Thursday 4. Blood 9.5) whilst showing selectivity over the pro-inflammatory cytoki...
Those hard to find references — B.R.S.M.
http://brsmblog.com/those-hard-to-find-references
Tet Lett. Is other people. Those hard to find references. In a recent group meeting the old Woodward aphorism came out again: "the only model system worth using is the enantiomer", which led to a scrabble afterwards to find. From - or (-)-camphor, for the final sequence they found that it was in fact more efficient to instead use a resolution of the earlier indoline, accomplished by derivatisation with (. Α-phenylethyl isocyanate and separation of the resulting diastereomers. Woodward put it thusly:.
How do people do it? | A PhD's Life
https://joshphd.wordpress.com/2012/02/01/how-do-people-do-it
A PhD's Life. My life as an Assistant Professor…. How do people do it? I suck at it! I truly envy people who have the ability to multitask. I have tried and tried to no avail. It seems that the harder I try to multitask, they more I focus on one task. I desperately need to learn to multitask because it really stinks only being able to focus on one task at a time. 8221; “Is that enough information? 8221; “Can I draw that figure better myself? 8221; The questions go on and on in my mind. Dr Dad, PhD. In th...
New Contract | A PhD's Life
https://joshphd.wordpress.com/2012/05/02/new-contract-2
A PhD's Life. My life as an Assistant Professor…. MY SEMESTER IS OVER! Not only that, but I gotta very nice 4% pay increase! I honestly cannot say enough about how much I love my job. It is the perfect job for me in every way. It is in the perfect location. It has the perfect balance between teaching and research (for me). I have great colleagues and great bosses. I really plan on staying here as long as they keep me around. Now back to planning out some syntheses! Laquo; Online Exams. Date : May 2, 2012.
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New Reactions | Reviewing new organic methodology, one paper at a time…
The Latest from the Literature. Life as a Reaction Junkie. On the Humorous Side…. Random but awesome…. From Zero to Highly Strained in 45 Minutes! Enantioselective Synthesis of 2-Arylbicyclo[1.1.0]butane Carboxylates. Qin, C. Davies, H. M. L. ASAP January 3rd, 2013. Happy New Year from New Reactions! 2013 brings another year of methodology blogging! I hope to send one of our excellent undergrads to work with him this summer. Via a Wurtz coupling method:. Finally, others started to get into the business o...
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