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Protein Evolution (Rob Russell)

Protein Evolution Heidelberg, Prof. Rob Russell

http://www.russelllab.org/

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Protein Evolution (Rob Russell) | russelllab.org Reviews
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Protein Evolution Heidelberg, Prof. Rob Russell
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1 Protein
2 Peptide
3 Motif
4 Interaction
5 Structure
6 Evolution
7 Interaction
8 Bioinformatics
9 Rob Russell
10 BioQuant
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protein evolution,prof rob russell,services,research,publications,group,mutations within medulloblastoma,predicting drug protein interactions,pepsite,mycoplasma modelling,wd40 peptide interactions,welcome,news,latest publications
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Protein Evolution (Rob Russell) | russelllab.org Reviews

https://russelllab.org

Protein Evolution Heidelberg, Prof. Rob Russell

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pepsite.russelllab.org pepsite.russelllab.org

PepSite

A structural method to predict peptide/protein binding. Evangelia Petsalaki, Alexander Stark, Eduardo Garcia Urdiales, Rob Russell. Please try our newer, better and faster Pepsite2. This service will be discontinued mid 2012. When using PepSite please cite: Petsalaki E, Stark A, GarcÃa-Urdiales E, Russell RB, Accurate prediction of peptide binding sites on protein surfaces, PLoS Comput Biol. Logo courtesy of Tim Heckenhausen.

pepsite2.russelllab.org pepsite2.russelllab.org

PepSite

Run PepSite on a PDB structure. Run PepSite on your own PDB file. Prediction of peptide binding sites on protein surfaces. Protein-peptide interactions are a vital part of many cellular signaling pathways (e.g., RTK signaling) and other cellular processes (e.g., endocytosis). A detailed view of such interactions enables a mechanistic description of how cell networks are regulated. When using PepSite 2, please cite:. PepSite: prediction of peptide-binding sites from protein surfaces.

pcidb.russelllab.org pcidb.russelllab.org

ProtChemSI: protein-chemical interaction database

The database of protein-chemical structural interactions. The current version includes data from the Protein Data Bank. As of August 2011. The database is updated monthly. Search for your favorite protein or chemical. Enter protein name or UniProt ID. OR search by FASTA sequence. Enter small molecule name or PubChem ID. OR search by SMILES string. With the Tanimoto score greater than (from 0 to 1). When referencing, please cite:. Design based on a template by CSS Templates.

mirna.russelllab.org mirna.russelllab.org

miRNA - Target Gene Prediction at EMBL

mirnas.russelllab.org mirnas.russelllab.org

miRNA - Target Gene Prediction at EMBL

lmd.russelllab.org lmd.russelllab.org

Linear Motif Discovery

Data from Neduva et al, PLoS Biol., 2005. DILIMOT server for Discovery of Linear Motifs. Protein linear motifs describe short (3-8 residue), common stretches of polypeptide chains that are associated with a specific function. They include phosphoarylation sites, other post-translational modifications, targetting signals for cellular compartments, protein cleavage sites and protein interaction modules. They are similar to protein domains. They are also non- globular. This prompted us in 2002 to start the ...

hub.russelllab.org hub.russelllab.org

Protein Evolution (Rob Russell)

Cancer genetics meets mechanism. Cancer genetics meets mechanism. Cancer genetics meets mechanism. Genetic variants in cryptic choleostasis. Genetic variants in cryptic choleostasis. Genetic variants in cryptic choleostasis. Functional genetic variants in healthy genomes. Functional genetic variants in healthy genomes. Cancer severity from interaction mechanisms. Cancer severity from interaction mechanisms. Cancer severity from interaction mechanisms. Cancer severity from interaction mechanisms. Protein ...

dilimot.russelllab.org dilimot.russelllab.org

Protein Evolution (Rob Russell)

Cancer genetics meets mechanism. Cancer genetics meets mechanism. Cancer genetics meets mechanism. Genetic variants in cryptic choleostasis. Genetic variants in cryptic choleostasis. Genetic variants in cryptic choleostasis. Functional genetic variants in healthy genomes. Functional genetic variants in healthy genomes. Cancer severity from interaction mechanisms. Cancer severity from interaction mechanisms. Cancer severity from interaction mechanisms. Cancer severity from interaction mechanisms. Protein ...

yeast-complexes.russelllab.org yeast-complexes.russelllab.org

Protein Evolution (Rob Russell)

Cancer severity from interaction mechanisms. Cancer severity from interaction mechanisms. Cancer severity from interaction mechanisms. Cancer severity from interaction mechanisms. Modelling of FFV gag protein. A landscape of the human cilium. A landscape of the human cilium. A landscape of the human cilium. A landscape of the human cilium. Mechismo: Mechanistic interpretation of structural modifications. Mechismo: Mechanistic interpretation of structural modifications. RhoA mutations in Burkitt's lymphoma.

3drepertoire.russelllab.org 3drepertoire.russelllab.org

Protein Evolution (Rob Russell)

Cancer severity from interaction mechanisms. Cancer severity from interaction mechanisms. Cancer severity from interaction mechanisms. Cancer severity from interaction mechanisms. Modelling of FFV gag protein. A landscape of the human cilium. A landscape of the human cilium. A landscape of the human cilium. A landscape of the human cilium. Mechismo: Mechanistic interpretation of structural modifications. Mechismo: Mechanistic interpretation of structural modifications. RhoA mutations in Burkitt's lymphoma.

INTERNAL PAGES

russelllab.org russelllab.org
1

Protein Evolution (Rob Russell)

http://www.russelllab.org/index.shtml

A landscape of the human cilium. A landscape of the human cilium. A landscape of the human cilium. A landscape of the human cilium. Mechismo: Mechanistic interpretation of structural modifications. Mechismo: Mechanistic interpretation of structural modifications. Mechismo: Mechanistic interpretation of structural modifications. Deducing protein-protein interaction mechanism from siRNA screens. RhoA mutations in Burkitt's lymphoma. JAK3 mutations in porlymphocytic leukemia. Correlated mutaions in HIV Gag.

2

Protein Evolution (Rob Russell)

http://www.russelllab.org/images.shtml

Figure shows the effect knocking down components of proteins where mutations lead to 3M syndrome have on cilia in mpkCCD cells. We hypothesized that 3M Syndrome is a previously undescribed ciliary disease. Figure shows the effect of variants in patients suffereing sever ciliary diseases and how they affect specific sub-complexes and interaction within the intraflagellar transport complex B. Figure shows the architecture of the intraflagellar transport complex B deduced by our Socioaffinity metric. Figure...

3

Protein Evolution (Rob Russell)

http://www.russelllab.org/publications.shtml

An organelle-specific protein landscape identifies novel diseases and molecular mechanisms. Boldt K*, van Reeuwijk J*, Lu Q. Koutroumpas K*, Nguyen TT, Texier Y, van Beersum SEC, Horn N, Willer JR, Mans DA, Dougherty G, Lamers IJ, Coene KLM, Arts HH, Betts MJ. Roepman R* Nat Commun. Genes encoding members of the JAK-STAT pathway or epigenetic regulators are recurrently mutated in T-cell prolymphocytic leukaemia. Lopez C, Bergmann AK, Paul U, Murga-Penas EM, Nagel I, Betts MJ. Schilhabel M, Schlesner M, S...

4

Services offered by Protein Evolution

http://www.russelllab.org/services.shtml

This tool lets you interrogate data from our collaborative project on the Ciliary proteome, where we identified nearly 5000 interactions and over 50 complexes, involving more than 1000 proteins in the cilia. From Boldt, van Reeuwijk, Lu, Koutroumpas et al Nat Commun. From Betts et al, Nucl Acids Res. A database of protein-chemical interactions predicted by structure superimpositions: if you are interested in chemicals that might bind a particular protein or vice versa, then check it out. From Stark et al...

5

Group Members in Protein Evolution

http://www.russelllab.org/group.shtml

Protein-protein interactions, Modelling, Computational administration. Chemistry, Biochemistry, Biophysics and Molecular Biology in the lab. GTPases, Structure, Modifications. YingYing Jiang (PhD Student). Juan-Carlos Gonzales (PhD Student). Protein modifications and structure. Gurdeep Singh (MSc Student). Alumni of the Russell Group. 11/05/2016 Ciliary landscape data now available. 15/04/2015 New group member Juan-Carlos Gonzalez (PhD Student). 27/01/2015 New group member Gurdeep Singh (MSc Student).

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Syscilia

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An EU FP7 Project. Radboud University Nijmegen Medical Centre. Eberhard Karls Universitaet Tuebingen. Prof Dr. Marius Ueffing [ 1. Radboud University Nijmegen Medical Centre. Radboud University Nijmegen Medical Centre. European Molecular Biology Laboratory. Duke University Medical Center. Prof Dr. Nicholas Katsanis. United States of America. Prof Dr. Gerd Walz. Johannes Gutenberg Universitaet Mainz. Prof Dr. Uwe Wolfrum. Telethon Institute of Genetics and Medicine. Universitair Medisch Centrum Utrecht.

pepsite2.russelllab.org pepsite2.russelllab.org

PepSite

http://pepsite2.russelllab.org/webservice

Run PepSite on a PDB structure. Run PepSite on your own PDB file. This PepSite web server can be accessed programmatically via a simple RESTful interface. Currently, the only implemented method is. Which queries an input peptide sequence against a protein surface identified via a PDB/chain code. Output format (see below). Web page with matches, scores, and molecular visualization. Plain text output with list of matches and scores. Match coordinates in pdb format. P-value of the best match in plain text.

pepsite2.russelllab.org pepsite2.russelllab.org

PepSite

http://pepsite2.russelllab.org/examples

Run PepSite on a PDB structure. Run PepSite on your own PDB file. RNEDD4 WWIII domain from Rattus norvegicus. WW domains bind [AP]-P-P-[AP]-Y, and/or phosphoserine- phosphothreonine-containing motifs. The PDB file with id 1i5h. Is a RNEDD4 WWIII domain bound to a ENaC peptide. For more information, please refer to the Kanelis et al (2011). You run PepSite on the bound structure by specifying PDB code 1i5h. Chain W, and peptide sequence GTPPPNYDSL (see results. 74 kDa type IV collagenase from Homo sapiens.

pepsite2.russelllab.org pepsite2.russelllab.org

PepSite

http://pepsite2.russelllab.org/about

Run PepSite on a PDB structure. Run PepSite on your own PDB file. PepSite was originally described in the following article:. Accurate prediction of peptide binding sites on protein surfaces. Petsalaki E, Stark A, García-Urdiales E, and Russell RB. Contributors to PepSite software development. V10 and original webserver). V2x and current webserver). Technical information about the PepSite webserver. Matches calculated with PepSite v2.2.20. Hot spots pre-calculated with PepSite v2.2.20.

pepsite2.russelllab.org pepsite2.russelllab.org

PepSite

http://pepsite2.russelllab.org/help

Run PepSite on a PDB structure. Run PepSite on your own PDB file. Follow the links below to jump to the help topic of your interest. How can I use PepSite? Can I access this web server programmatically? What are the supported peptide residues? How are molecular visualizations generated? Can I provide a UniProt ID or accession instead of a PDB code? How should I cite this web server? Is PepSite merely finding cavities or conserved surfaces or both? How can I use PepSite? On the form on the left. Molecular...

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The City Of Russell, KY.

Welcome To The City of Russell! Russell is one of the shining jewels in the crown of Greenup County. Welcome to the City of Russell website. Established in 1874, Russell is one of the shining jewels in the crown of Greenup County. This website contains information pertaining to sanitation, water, and sewer services for all Russell residents. City council meets at the City Building, 410 Ferry St. on every fourth monday of each month at 6:00pm. Http:/ www.russellky.net. The City Of Russell, KY.

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Russell Kyle | Webdesign & Development

I create and design websites and web applications for people, organizations, buisnesses and products. If you need a new website or just want to upgrade an existing one contact me today! I design great looking websites that geared torwards you, your company or your product. As a client you are encouraged to provide feedback at each step of the design process. This will ensure that your vision matches the final design. I don’t just design great looking websites, we also create the code that makes them run.

russelllab.org russelllab.org

Protein Evolution (Rob Russell)

Mechismo: Mechanistic interpretation of structural modifications. Mechismo: Mechanistic interpretation of structural modifications. Mechismo: Mechanistic interpretation of structural modifications. Deducing protein-protein interaction mechanism from siRNA screens. RhoA mutations in Burkitt's lymphoma. JAK3 mutations in porlymphocytic leukemia. Molecular dissection of Argonaute by DNA shuffling. Mutations within ID3 at the TCF3/4 interface. Correlated mutaions in HIV Gag. More information about the images.

russelllabel.com russelllabel.com

Russell Label & Packaging Co.

Gift, Apparel, Gable, and Jewelry Boxes. Labels, Tags and Seals. Pricing Machines, Ink Rollers, and Labels. Ribbon, Bows, and Wraphia. Items - $0.00. Hi&Lo density Plastic bags. Printed Rope Handle Shopping Bag. Everyday / Solid Color Gift Wrap. Holiday / Celibration Gift Wrap. Gift, Apparel, Gable, and Jewelry Boxes. Presentation / Pop Up Gift Card Boxes. Labels, Tags and Seals. Price Labels / Sale Labels. Pricing Machines, Ink Rollers, and Labels. 1 Line Pricing Machine Labels. Ribbon, Bows, and Wraphia.

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Russell Labs - The artist portfolio of Earl J. Russell.

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Russell Lacy

Includes high-quality download in MP3, FLAC and more. Paying supporters also get unlimited streaming via the free Bandcamp app. Need A New Love. All the Little Spiders. Louisiana Blues (Mr. Lightnin Hopkins). Before You Wake Up. This album was recorded during the making of Jordan Tarrants Lazarus, on the same tascamm 388 reel to reel recorder at The Virginia Moonwalker. Released November 27, 2013. Russell Lacy-all music except. No hate in my heart. You know who you are. Feeds for this album.

russelllacymusic.com russelllacymusic.com

Russell Lacy Music - Music Instruction in Durham, NC

2014 Russell Lacy Music Photography by Natalia Weedy. Design by Will Dean. In his performing career, Russell has shared the stage with John Hart, John Bailey, Frank Kimbrough, Steve Cardenas, Bobby Porcelli, David Berkman, Michael Blake Band, Branford Marsalis, Joey Calderazzo, Eric Reed, Delfayo Marsalis, Ellis Marsalis, Pete McCann, and Gregory Tardy. Since 2008, Russell has concentrated his efforts on developing the Trachy/Lacy Collective. Nick earned a full music-performance scholarship to study drum...

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Russell Lahodny Photography & Design

Russell Lahodny Photography and Design. Immerse yourself in a visual adventure courtesy of photojournalist Russell Lahodny as he shares his depictions of travel and everday life through his raw imagery.